11.
    发明专利
    未知

    公开(公告)号:FR2834340A1

    公开(公告)日:2003-07-04

    申请号:FR0116981

    申请日:2001-12-28

    Abstract: An equipment includes an excitation source ( 1 ), elements for injecting ( 2 ) an excitation signal produced by the source in an ordered bundle ( 3 ) of flexible optical fibers, elements for analyzing ( 21, 22 ) an emitted autofluorescence signal. The equipment also includes at the output of the optical fiber bundle ( 3 ) an optical head ( 4 ) designed to be placed in contact with the biological tissue ( 6 ), the optical head being equipped with optical elements adapted to cause the excitation signal output from the bundle ( 3 ) to converge into a subsurface analyzing zone ( 5 ), the same optical fiber(s) used for excitation of the bundle ( 3 ) being used for detecting the signal emitted by the subsurface analyzing zone, elements (D) placed upstream of the injection elements ( 2 ) being further provided to separate the wavelength of the excitation signal and the wavelength of the autofluorescence signal.

    Procedimiento y sistema de diagnóstico por imagen microscópica de fluorescencia de fibras de multimarcado

    公开(公告)号:ES2402433T3

    公开(公告)日:2013-05-03

    申请号:ES05777324

    申请日:2005-06-09

    Abstract: Procedimiento para realizar una imagen microscópicProcedimiento para realizar una imagen microscópica fibrada de fluorescencia de una muestra, en la qa fibrada de fluorescencia de una muestra, en la que: - la muestra se explora por medio de una señalue: - la muestra se explora por medio de una señal de excitación a través de un camino óptico que co de excitación a través de un camino óptico que comprendeal menos una fibra óptica, - se detecta la mprendeal menos una fibra óptica, - se detecta la señal de fluorescencia procedente de dicha muestraseñal de fluorescencia procedente de dicha muestra, la señal de excitación y la señal defluorescenci, la señal de excitación y la señal defluorescencia que toma este mismo camino óptico; - se excitan,a que toma este mismo camino óptico; - se excitan, a través del camino óptico, al menos dos fluorófo a través del camino óptico, al menos dos fluoróforos contenidos en la muestra, - se detecta, a travros contenidos en la muestra, - se detecta, a través del camino óptico, la señal de fluorescencia deés del camino óptico, la señal de fluorescencia de cada uno de dichos al menos dosfluoróforos, y - s cada uno de dichos al menos dosfluoróforos, y - se elabora una imagen final que contiene zonas coloe elabora una imagen final que contiene zonas coloreadas en función de dichos al menos dos fluoróforreadas en función de dichos al menos dos fluoróforos,caracterizado porque se adquiere además un espeos,caracterizado porque se adquiere además un espectro de cada imagen a partir de una parte de la sectro de cada imagen a partir de una parte de la señal queproviene de la muestra a través del camino ñal queproviene de la muestra a través del camino óptico. óptico.

    15.
    发明专利
    未知

    公开(公告)号:FR2834340B1

    公开(公告)日:2004-07-16

    申请号:FR0116981

    申请日:2001-12-28

    Abstract: An equipment includes an excitation source ( 1 ), elements for injecting ( 2 ) an excitation signal produced by the source in an ordered bundle ( 3 ) of flexible optical fibers, elements for analyzing ( 21, 22 ) an emitted autofluorescence signal. The equipment also includes at the output of the optical fiber bundle ( 3 ) an optical head ( 4 ) designed to be placed in contact with the biological tissue ( 6 ), the optical head being equipped with optical elements adapted to cause the excitation signal output from the bundle ( 3 ) to converge into a subsurface analyzing zone ( 5 ), the same optical fiber(s) used for excitation of the bundle ( 3 ) being used for detecting the signal emitted by the subsurface analyzing zone, elements (D) placed upstream of the injection elements ( 2 ) being further provided to separate the wavelength of the excitation signal and the wavelength of the autofluorescence signal.

    TETE OPTIQUE DE FOCALISATION MINIATURISEE, NOTAMMENT POUR ENDOSCOPE

    公开(公告)号:CA2471724C

    公开(公告)日:2012-03-13

    申请号:CA2471724

    申请日:2002-12-20

    Abstract: Elle est prévue pour équiper l'extrémité distale d'un faisceau de fibres optiques souples (2), destinée à venir au contact d'une surface d'analyse et comprenant des moyens optiques (3) pour focaliser un signal d'excitation en un point focal dit d'excitation situé à une profondeur donnée sous la surface d'analyse et pour prélever un signal rétroémis par le point focal d'excitation qui est véhiculé en retour par ledit faisceau de fibres. Elle est caractérisée par un tube porte-optique (4) au sein duquel sont introduits d'un côté la partie terminale distale (1) du faisceau de fibres (2) et de l'autre les moyens optiques, ces derniers comprenant une lame (21) placée au contact de l'extrémité (14) du faisceau de fibres dont l'indice est proche de celui du coeur des fibres et un bloc optique de focalisation (3), un hublot de sortie (30) étant en outre prévu adapté à réaliser une adaptation d'indice de manière à s'affranchir de la réflexion parasite s'opérant sur la surface d'analyse.

    18.
    发明专利
    未知

    公开(公告)号:DE60209942T2

    公开(公告)日:2006-11-30

    申请号:DE60209942

    申请日:2002-12-20

    Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.

    20.
    发明专利
    未知

    公开(公告)号:FR2834348B1

    公开(公告)日:2004-02-27

    申请号:FR0116979

    申请日:2001-12-28

    Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.

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