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公开(公告)号：AU2006330947B2
公开(公告)日：2012-04-12
申请号：AU2006330947
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： BIBILLO AREK , MITSIS PAUL , PHAM THANG , CHRISTIANS FRED C , MURPHY DEVON , PARK INSIL , HANZEL DAVID K , LYLE JOHN , RANK DAVID R , CLARK SONYA , PELUSO PAUL , OTTO GEOFF
IPC: C12Q1/68
Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
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公开(公告)号：CA2645758C
公开(公告)日：2016-08-09
申请号：CA2645758
申请日：2007-03-29
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF , CICERO RONALD L
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
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公开(公告)号：AU2007309504A1
公开(公告)日：2008-05-02
申请号：AU2007309504
申请日：2007-10-22
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： HANZEL DAVID K , BIBILLO AREK , PELUSO PAUL , WEGENER JEFF , RANK DAVID R
Abstract: Compositions that include DNA polymerases having increased residence times for nucleotide analogues, particularly modified recombinant Φ29-type DNA polymerases with such increased residence times, are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA amplification are also provided. Compositions including α-thiophosphate nucleotide analogues with four or more phosphate groups are described, as are methods for determining the sequence of nucleic acid molecules using such analogues.
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公开(公告)号：AU2007309504B2
公开(公告)日：2012-09-13
申请号：AU2007309504
申请日：2007-10-22
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： PELUSO PAUL , RANK DAVID R , BIBILLO AREK , WEGENER JEFF , HANZEL DAVID K
Abstract: Compositions that include DNA polymerases having increased residence times for nucleotide analogues, particularly modified recombinant Φ29-type DNA polymerases with such increased residence times, are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA amplification are also provided. Compositions including α-thiophosphate nucleotide analogues with four or more phosphate groups are described, as are methods for determining the sequence of nucleic acid molecules using such analogues.
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15.发明专利
公开(公告)号：ES2385015T3
公开(公告)日：2012-07-17
申请号：ES07754529
申请日：2007-03-29
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF , CICERO RONALD L
Abstract: Un método de proporcionar un sustrato que tiene una enzima inmovilizada selectivamente sobre él, comprendiendoel método:proporcionar un sustrato que tiene un primer componente de la superficie que comprende SiO2 y un segundocomponente de la superficie que comprende un metal u óxido metálico;poner en contacto el sustrato con una primera composición que se asocia selectivamente con el primer componentede la superficie, comprendiendo dicha primera composición un silano;acoplar la enzima a la primera composición; yponer en contacto el sustrato con una segunda composición que se asocia selectivamente con el segundocomponente de la superficie, comprendiendo dicha segunda composición un compuesto que comprende uno o másgrupos ácido fosfónico o fosfato.
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Patent Agency Ranking
公开(公告)号：CA2666517A1
公开(公告)日：2008-05-02
申请号：CA2666517
申请日：2007-10-22
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： BIBILLO AREK , HANZEL DAVID K , RANK DAVID R , PELUSO PAUL , WEGENER JEFF
Abstract: Compositions that include DNA polymerases having increased residence time s for nucleotide analogues, particularly modified recombinant .PHI.29-type D NA polymerases with such increased residence times, are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA a mplification are also provided. Compositions including .alpha.-thiophosphate nucleotide analogues with four or more phosphate groups are described, as a re methods for determining the sequence of nucleic acid molecules using such analogues.
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公开(公告)号：CA2645758A1
公开(公告)日：2007-11-01
申请号：CA2645758
申请日：2007-03-29
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： OTTO GEOFF , WEGENER JEFFERY , KORLACH JONAS , RANK DAVID R , XU YUE , PELUSO PAUL , ROITMAN DANIEL , TURNER STEPHEN , LYLE JOHN
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
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公开(公告)号：AU2006330947A1
公开(公告)日：2007-07-05
申请号：AU2006330947
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： BIBILLO AREK , MITSIS PAUL , PHAM THANG , CHRISTIANS FRED C , MURPHY DEVON , PARK INSIL , HANZEL DAVID K , LYLE JOHN , RANK DAVID R , CLARK SONYA , PELUSO PAUL , OTTO GEOFF
IPC: C12Q1/68
Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
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公开(公告)号：EP1963536A4
公开(公告)日：2010-03-03
申请号：EP06848948
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： HANZEL DAVID K , OTTO GEOFF , MURPHY DEVON , PELUSO PAUL , PHAM THANG , RANK DAVID R , MITSIS PAUL , CHRISTIANS FRED C , BIBILLO AREK , PARK INSIL , CLARK SONYA , LYLE JOHN
IPC: C12Q1/68
CPC classification number: C12N9/1252 , C07K2319/20 , C12P19/34 , C12Q1/6827 , C12Q1/6869 , C12Y207/07007 , Y02P20/52
Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
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20.发明公开POLYMERASE ENZYMES AND REAGENTS FOR ENHANCED NUCLEIC ACID SEQUENCING 审中-公开聚合酶及试剂高级NUKEINSÄURESEQUENZIERUNG
公开(公告)号：EP2089517A4
公开(公告)日：2010-10-20
申请号：EP07867267
申请日：2007-10-22
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： RANK DAVID R , BIBILLO AREK , HANZEL DAVID K , PELUSO PAUL , WEGENER JEFF
CPC classification number: C12N9/1252 , C12P19/34
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