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    STEREOSELECTIVE REDUCTION OF SUBSTITUTED OXO-BUTANES
    14.
    发明公开
    STEREOSELECTIVE REDUCTION OF SUBSTITUTED OXO-BUTANES 有权
    取代OXO丁烷STEREO选择还原

    公开(公告)号：EP1309714A4

    公开(公告)日：2006-04-05

    申请号：EP01959109

    申请日：2001-07-20

    Applicant: SQUIBB BRISTOL MYERS CO

    Inventor： PATEL RAMESH N ,  CHU LINDA

    IPC: C12P13/02 ,  C07D301/26 ,  C07D303/36 ,  C12P13/00 ,  C12R1/01 ,  C12S99/00 ,  C12P7/02

    CPC classification number: C12P13/001

    Abstract: The present invention relates to a process for the stereoselective enzymatic reduction of 1-halo-2-oxo-3-(protected)amino-4-substituted-butanes utilizing certain species of Rhodococcus and Brevibacterium. The product 1-halo-2-oxo-3-(protected)amino-4-substituted-butanes, which are useful as intermediates in the synthesis of compounds that are inhibitors of ACE, renin and HIV proteases, are obtained in high yield and, particularly, in very high diastereometric purity. The process is advantageously highly selective for the 1S,2S enantiomer of the product.

    PICHIA PASTORIS FORMATE DEHYDROGENASE AND USES THEREFOR
    17.
    发明公开
    PICHIA PASTORIS FORMATE DEHYDROGENASE AND USES THEREFOR 审中-公开
    从毕赤酵母甲酸脱氢酶及其用途

    公开(公告)号：EP1463807A4

    公开(公告)日：2006-04-12

    申请号：EP02794274

    申请日：2002-12-16

    Applicant: SQUIBB BRISTOL MYERS CO

    Inventor： GOLDBERG STEVEN L ,  CINO PAUL M ,  PATEL RAMESH N ,  NANDURI VENKATA B ,  JOHNSTON ROBERT M

    IPC: C12N9/02 ,  C12P21/04 ,  C12Q1/26 ,  C12N9/04 ,  C07H21/04 ,  C12N1/20 ,  C12N15/00

    CPC classification number: C12N9/0004 ,  C12Q1/26 ,  G01N2333/04

    Abstract: This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encoding P. pastoris FDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinant P. pastoris FDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind to P. pastoris FDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated P. pastoris FDH nucleic acids, polypeptides, and antibodies, and methods of using P. pastoris FDH in various reactions for industrial or pharmaceutical applications.

    PROCESS FOR THE PREPARATION OF C-4 DEACETYLTAXANES
    19.
    发明公开
    PROCESS FOR THE PREPARATION OF C-4 DEACETYLTAXANES 有权
    VERFAHREN ZUR HERSTELLUNG VON C-4-DEACETYLTAXANEN

    公开(公告)号：EP1105380A4

    公开(公告)日：2002-01-02

    申请号：EP99937759

    申请日：1999-08-03

    Applicant: SQUIBB BRISTOL MYERS CO

    Inventor： HANSON RONALD L ,  PATEL RAMESH N

    IPC: C12N9/18 ,  C07D305/14 ,  C12P15/00 ,  C12P17/02 ,  C12R1/01 ,  C12N9/00

    CPC classification number: C07D305/14 ,  C12P15/00

    Abstract: A process useful for the preparation of intermediates in synthesis or semi-synthesis of paclitaxel analogs wherein a starting taxane such as 10-deacetylbaccatin III is deacetylated at the C-4 position using a microorganism or an enzyme derived therefrom to provide 4-deacetyltaxanes, such as 4,10-dideacetylbaccatin III.

    Abstract translation: 可用于制备紫杉醇类似物的合成或半合成中的中间体的方法，其中起始紫杉烷例如10-脱乙酰基浆果赤霉素III在C-4位使用微生物或由其衍生的酶脱乙酰化得到4-脱乙酰基紫杉烷，例如 作为4,10-二脱乙酰基浆果赤霉素III。

    20.
    发明专利
    未知

    公开(公告)号：BR0113236B1

    公开(公告)日：2014-04-22

    申请号：BR0113236

    申请日：2001-07-20

    Applicant: SQUIBB BRISTOL MYERS CO

    Inventor： PATEL RAMESH N ,  CHU LINDA

    IPC: C12P7/02 ,  C12P13/02 ,  C07D301/26 ,  C07D303/36 ,  C12P13/00 ,  C12R1/01 ,  C12S99/00

    Abstract: The present invention relates to a process for the stereoselective enzymatic reduction of 1-halo-2-oxo-3-(protected)amino-4-substituted-butanes utilizing certain species of Rhodococcus and Brevibacterium. The product 1-halo-2-hydroxy-3-(protected)amino-4-substituted-butanes, which are useful as intermediates in the synthesis of compounds that are inhibitors of ACE, renin and HIV proteases, are obtained in high yield and, particularly, in very high diastereomeric purity. The process is advantageously highly selective for the (3S,2R) enantiomer of the product.

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