公开(公告)号：JPH1087561A

公开(公告)日：1998-04-07

申请号：JP23949496

申请日：1996-09-10

Applicant: TORAY INDUSTRIES

Inventor： ENDO ITARU ,  IMAMURA SHINZO

IPC: C07C51/347 ,  C07C51/41 ,  C07C65/05

Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound useful as a raw material of medicine, agrochemical material and liquid crystalline polymer, by adding a compound exhibiting a strong acidity to a dialkali metal salt of p-hydroxybenzoic acid and separating by a concentration, etc. SOLUTION: This method for producing a monoalkali metal salt of p- hydroxybenzoic acid is to add a compound exhibiting stronger acidity than that of a phenolic hydroxyl group in p-hydroxybenzoic acid, preferably a mineral acid, an aromatic carboxylic acid and an aliphatic carboxylic acid to a dialkali metal salt of p-hydroxybenzoic acid in an aprotic polar solvent such as dimethylsulfoxide, dimethylformamide and dimethylacetamide, then separate the monoalkali metal salt of p-hydroxybenzoic acid by a concentration or a filtration.

公开(公告)号：JP2505466B2

公开(公告)日：1996-06-12

申请号：JP15499287

申请日：1987-06-22

Applicant: TORAY INDUSTRIES

Inventor： SATO HARUYO ,  ITO NORIKO ,  IMAMURA SHINZO

IPC: C12P41/00 ,  C12R1/01 ,  C12R1/19 ,  C12R1/22 ,  C12R1/425 ,  C12R1/645 ,  C12R1/72 ,  C12R1/73 ,  C12R1/78

公开(公告)号：JPH07165702A

公开(公告)日：1995-06-27

申请号：JP34088493

申请日：1993-12-09

Applicant: TORAY INDUSTRIES

Inventor： ONO TAKAE ,  SATOU HARUYO ,  IMAMURA SHINZO

IPC: C07C403/20

Abstract: PURPOSE:To isolate a natural type abscisic acid being an important compound as a natural plant hormone and capable of expecting wide uses such as plant growth regrator, etc., in high purity and yield from a solution containing the natural type abscisic acid by carrying out the isolation operation of the natural type abscisic acid in a state in which light having a specific wavelength is blocked. CONSTITUTION:A natural type abscisic acid is isolated in high yield from a solution containing the natural type abscisic acid by carrying out isolation operation of the natural type abscisic acid in a state in which light having 200-600nm wavelength is blocked. This isolation is preferably carried out under conditions at pH1-11 and temperature of 0-60 deg.C. An >=80% of total isolation operation based on time is preferably carried out in a state in which light having 200-600nm wavelength is blocked. Furthermore, the natural type abscisic acid(ABA) is (+)-cis-trans type expressed by the formula. The isomerization and decomposition of ABA are suppressed and recovery of ABA is enhanced and ABA can efficiently be isolated by this method. Further, since the isolated ABA is not isolated or decomposed even in successive operation, high-purity ABA is readily obtained.

公开(公告)号：JPH0677B2

公开(公告)日：1994-01-05

申请号：JP21245584

申请日：1984-10-12

Applicant: TORAY INDUSTRIES

Inventor： SODA KENJI ,  SATO HARUYO ,  TANAKA NORIKO ,  IMAMURA SHINZO

IPC: C07C59/08 ,  C07C51/00 ,  C07C51/02 ,  C07C51/367 ,  C07C67/00 ,  C12P7/56 ,  C12P41/00 ,  C12R1/40

公开(公告)号：JPH0378999B2

公开(公告)日：1991-12-17

申请号：JP12520584

申请日：1984-06-20

Applicant: TORAY INDUSTRIES

Inventor： MYATA AKIRA ,  IMAMURA SHINZO ,  OONO AKIRA

IPC: C12P13/20 ,  C12R1/645 ,  C12R1/72

公开(公告)号：JPH0311091A

公开(公告)日：1991-01-18

申请号：JP14386789

申请日：1989-06-06

Applicant: TORAY INDUSTRIES

Inventor： FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  MUTOU MASATO ,  OKAMOTO YUTAKA

IPC: C07D307/33 ,  A61K31/555 ,  A61K33/24 ,  A61P35/00 ,  C07C211/65 ,  C07F15/00

Abstract: NEW MATERIAL:The compound containing spiculisporato-(trans-l-1,2- diaminocyclohexane)platinum expressed by formula I. USE:A remedy for malignant tumor. PREPARATION:The objective compound can be produced by reacting dinitrato(1,2-diaminocyclohexane)platinum(II) or sulfato(1,2-diaminocyclohexane)platinum(II) of formula II [R is (NO3)2 or SO4] with spiculisporic acid of formula III in the presence of an alkali metal or alkaline-earth metal hydroxide (preferably sodium hydroxide, potassium hydroxide or barium hydroxide) or reacting dihydroxo(1,2-diaminocyclohexane)platinum(II) of formula IV with the compound of formula III.

公开(公告)号：JPH02311489A

公开(公告)日：1990-12-27

申请号：JP13077889

申请日：1989-05-24

Applicant: TORAY INDUSTRIES

Inventor： FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  MUTOU MASATO ,  OKAMOTO YUTAKA

IPC: A61K31/28 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00 ,  C07C211/65 ,  C07C233/84 ,  C07F15/00

Abstract: NEW MATERIAL:Bis-(N-acetyltranexamato)-(trans-1,2-diaminocyclohexane) platinum (II)-containing compound shown by formula I. USE:A treating agent for malignant tumor. PREPARATION:A dinitrato(1,2-diaminocyclohexane) platinum (II) or sulfato(1,2- diaminocyclohexane) platinum (II) shown by formula II [R is (NO3)2 or SO4] or a platinum (II) compound shown by formula III is reacted with a compound shown by formula IV in the presence of an alkaline (earth) metallic hydroxide.

公开(公告)号：JPH01165594A

公开(公告)日：1989-06-29

申请号：JP32649787

申请日：1987-12-22

Applicant: TORAY INDUSTRIES

Inventor： MUTOU MASANORI ,  FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  SUGAWARA YOSHINORI

IPC: C07D207/452 ,  C07F15/00

Abstract: NEW MATERIAL:A compound expressed by formula I. USE:A remedy for malignant tumor having low toxicity. PREPARATION:N-(4-Carboxylphenyl)maleimide expressed by formula II is reacted with dihydroxodiaminocyclohexane platinum (II) expressed by formula III, normally under ordinary temperature and ordinary pressure in an aqueous solution to provide the compound expressed by formula I. Furthermore, the compound expressed by formula III which is a starting raw material is produced by heating N-(4-carboxyphenyl)maleimide in an acetic anhydride solvent in the presence of sodium acetate. The compound expressed by formula III is produced by reacting a compound expressed by the formula K2PtCl4 with a compound expressed by formula IV, reacting the resultant compound expressed by formula V with AgNO3 and then treating the resultant compound expressed by formula VI with a OH type anion exchange resin.

公开(公告)号：JPH01163192A

公开(公告)日：1989-06-27

申请号：JP32230187

申请日：1987-12-18

Applicant: TORAY INDUSTRIES

Inventor： HASEGAWA SAKIE ,  IMAMURA SHINZO ,  MUTOU MASANORI ,  OKAMOTO YUTAKA

IPC: A61K33/24 ,  A61K31/555 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:A compound expressed by formula I (R represents 1-17C alkyl). EXAMPLE:5-Acetyl-2,4,6(1H,3H,5H)-pyrimidine-trione-hydroxo(trans-l-1,2- diaminocyclohexane)platinum(II) complex.monohydrate. USE:A remedy for malignant tumor, which is administrated at 0.01-50mg per day.adult body weight. PREPARATION:Dinitrato(1,2-diaminocyclohexane)platinum (II) expressd by formula II is reacted with a 5-acyl-2,4,6(1H,3H,5H)-pyrimidine-trione in the presence of an alkali hydroxide normally at ordinary temperature under ordinary pressure.

公开(公告)号：JPH01163190A

公开(公告)日：1989-06-27

申请号：JP32229987

申请日：1987-12-18

Applicant: TORAY INDUSTRIES

Inventor： MUTOU MASANORI ,  FUJIKAWA KAZUHIRO ,  IMAMURA SHINZO ,  HASHIMOTO HIDEYUKI

IPC: A61K33/24 ,  A61K31/555 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:Bisphthaloylglycylglycinato-(trans->=-diaminocyclohexane) platinum(II) complex expressed by formula I. USE:A remedy for a malignant tumor with low toxicity and hardly any side-effect. PREPARATION:A sodium hydroxide-aqueous solution of sodium phthaloylglycylglycine expressed by formula II is reacted with an aqueous solu tion of dinitrate diaminocyclohexaneplatinum(II) diaquo complex expressed by formula III at normal temperature -100 deg.C under normal pressure.