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公开(公告)号：AU2022401847A1
公开(公告)日：2024-06-06
申请号：AU2022401847
申请日：2022-11-29
Applicant: VERTEX PHARMA
Inventor： SENTER TIMOTHY J , DAKIN LESLIE A , CHEN MING , STONE STEVEN D , DOLGIKH ELENA , OLSEN JESSICA H , WANG HAOXUAN
IPC: A61P13/12 , A61K31/438 , A61P35/00 , C07D221/20 , C07D471/10 , C07D491/107 , C07D495/10 , C07F5/02 , C07F7/18
Abstract: The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula I, tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD). (I)
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公开(公告)号：AU2022402839A1
公开(公告)日：2024-05-30
申请号：AU2022402839
申请日：2022-11-30
Applicant: VERTEX PHARMA
Inventor： DAKIN LESLIE A , BRODNEY MICHAEL A , DOLGIKH ELENA , OLSEN JESSICA H , SENTER TIMOTHY J , SHIMIZU AKIRA J , STONE STEVEN D , DANIEL KEVIN B , GARCIA BARRANTES PEDRO M , MEDEK ALES , TSAY CHARLENE
IPC: C07D211/52 , A61K31/451 , A61K31/454 , A61K31/4545 , A61P13/00 , A61P35/00 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04 , C07D498/04
Abstract: The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula (I), tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).
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公开(公告)号：CA3240523A1
公开(公告)日：2023-06-08
申请号：CA3240523
申请日：2022-11-29
Applicant: VERTEX PHARMA
Inventor： SENTER TIMOTHY J , DAKIN LESLIE A , CHEN MING , STONE STEVEN D , DOLGIKH ELENA , OLSEN JESSICA H , WANG HAOXUAN
IPC: A61K31/438 , A61P13/12 , A61P35/00 , C07D221/20 , C07D471/10 , C07D491/107 , C07D495/10 , C07F5/02 , C07F7/18
Abstract: The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula I, tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD). (I)
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公开(公告)号：JOP20210130A1
公开(公告)日：2023-01-30
申请号：JOP20210130
申请日：2019-12-17
Applicant: VERTEX PHARMA
Inventor： SHI YI , MEDEK ALES , BRODNEY MICHAEL , DAKIN LESLIE A , DORSCH WARREN A , DENIS FRANCOIS , ROSE PETER , SENTER TIMOTHY J , SHRESTHA MUNA , SAYEGH CAMIL , GAGNON KEVIN , FORTIER ANNE , CAO JINGRONG , KRUEGER ELAINE B , COME JON H , LEDFORD BRIAN , NANTHAKUMAR SUGANTHINI S , NICOLAS OLIVIER , HAMEL MARTINE , HU KAN-NIAN , WANG TIANSHENG , WITKOS FAITH
Abstract: غيرمتوفر
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公开(公告)号：CR20210383A
公开(公告)日：2021-09-22
申请号：CR20210383
申请日：2019-12-17
Applicant: VERTEX PHARMA
Inventor： NANTHAKUMAR SUGANTHINI S , GAGNON KEVIN , DAKIN LESLIE A , HU KAN-NIAN , MEDEK ALES , SHI YI , SHRESTHA MUNA , DENIS FRANCOIS , KRUEGER ELAINE B , WITKOS FAITH , CAO JINGRONG , HAMEL MARTINE , LEDFORD BRIAN , NICOLAS OLIVIER , COME JON H , DORSCH WARREN A , FORTIER ANNE , ROSE PETER , SAYEGH CAMIL , WANG TIANSHENG , BRODNEY MICHAEL , SENTER TIMOTHY J
IPC: A61K31/4025 , A61P13/12 , C07D403/12
Abstract: La descripción proporciona al menos una entidad seleccionada de compuestos de la fórmula ( I ), formas en estado sólido de ellos, composiciones que los comprenden y métodos que los usan, incluyendo el uso en el tratamiento de glomeruloesclerosis segmentaria focal (FSGS) y/o enfermedad renal no diabética (NDKD).
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Patent Agency Ranking
公开(公告)号：AU2023218940A1
公开(公告)日：2024-08-22
申请号：AU2023218940
申请日：2023-02-08
Applicant: VERTEX PHARMA
Inventor： SENTER TIMOTHY J , CHEN MING , DAKIN LESLIE A , GALE-DAY ZACHARY , NAMIREMBE SHEILA , OLSEN JESSICA H , SHIMIZU AKIRA J , WANG HAOXUAN , WANG TIANSHENG
IPC: C07D401/06 , A61K31/438 , A61K31/444 , A61K31/506 , A61P13/12 , A61P35/00 , C07D401/14 , C07D471/10 , C07D491/107 , C07D495/10 , C07D519/00
Abstract: The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula I, tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).
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公开(公告)号：IL312747A
公开(公告)日：2024-07-01
申请号：IL31274724
申请日：2024-05-09
Applicant: VERTEX PHARMA , BRODNEY MICHAEL A , DAKIN LESLIE A , DANIEL KEVIN B , DOLGIKH ELENA , GARCIA BARRANTES PEDRO M , MEDEK ALES , OLSEN JESSICA H , SENTER TIMOTHY J , SHIMIZU AKIRA J , STONE STEVEN D , TSAY CHARLENE
Inventor： BRODNEY MICHAEL A , DAKIN LESLIE A , DANIEL KEVIN B , DOLGIKH ELENA , GARCIA BARRANTES PEDRO M , MEDEK ALES , OLSEN JESSICA H , SENTER TIMOTHY J , SHIMIZU AKIRA J , STONE STEVEN D , TSAY CHARLENE
Abstract: The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula I, tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).
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公开(公告)号：UA128375C2
公开(公告)日：2024-06-26
申请号：UAA202104153
申请日：2019-12-17
Applicant: VERTEX PHARMA
Inventor： BRODNEY MICHAEL , GAGNON KEVIN , HU KAN-NIAN , MEDEK ALES , ROSE PETER , SHI YI , SHRESTHA MUNA , WITKOS FAITH , CAO JINGRONG , COME JON H , DAKIN LESLIE A , DENIS FRANCOIS , DORSCH WARREN A , FORTIER ANNE , HAMEL MARTINE , KRUEGER ELAINE B , LEDFORD BRIAN , NANTHAKUMAR SUGANTHINI S , NICOLAS OLIVIER , SAYEGH CAMIL , SENTER TIMOTHY J , WANG TIANSHENG
Abstract: Увинаходізапропонованащонайменшеоднасполука, вибраназісполукформули (I), їїтвердофазніформи, щомістятьїїкомпозиціїтаспособиїїзастосування, втомучисліприлікуванніфокально-сегментарногогломерулосклерозу (ФСГС) і/абонедіабетичногозахворюваннянирок (НДЗН). 323
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公开(公告)号：JOP20210129A1
公开(公告)日：2023-01-30
申请号：JOP20210129
申请日：2019-12-17
Applicant: VERTEX PHARMA
Inventor： SHI YI , MEDEK ALES , BRODNEY MICHAEL , DAKIN LESLIE A , DORSCH WARREN A , DENIS FRANCOIS , ROSE PETER , SENTER TIMOTHY J , SHRESTHA MUNA , SAYEGH CAMIL , GAGNON KEVIN , FORTIER ANNE , CAO JINGRONG , KRUEGER ELAINE B , COME JON H , LEDFORD BRIAN , NANTHAKUMAR SUGANTHINI S , NICOLAS OLIVIER , HAMEL MARTINE , HU KAN-NIAN , WANG TIANSHENG , WITKOS FAITH
Abstract: غيرمتوفر
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公开(公告)号：AU2021213758A1
公开(公告)日：2022-09-01
申请号：AU2021213758
申请日：2021-01-28
Applicant: VERTEX PHARMA
Inventor： CAO JINGRONG , COME JON H , DAKIN LESLIE A , DENIS FRANCOIS , DORSCH WARREN A , FORTIER ANNE , HAMEL MARTINE , KRUEGER ELAINE B , LEDFORD BRIAN , MALTAIS FRANCOIS , NANTHAKUMAR SUGANTHINI S , NICOLAS OLIVIER , SAYEGH CAMIL E , SENTER TIMOTHY J , WANG TIANSHENG
IPC: C07D209/12 , A61K31/404 , A61P13/12 , C07D209/18 , C07D401/12 , C07D403/12 , C07D407/12 , C07D413/12
Abstract: The disclosure provides at least one entity chosen from compounds of Formula (I) pharmaceutically acceptable salts thereof, solvates of any of the foregoing, and deuterated derivatives of any of the foregoing, compositions comprising the same, and methods of using the same, including use in treating APOL1 mediated kidney disease.
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