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公开(公告)号：SI3421468T1
公开(公告)日：2021-03-31
申请号：SI201431743
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , NUGENT WILLIAM ALOYSIUS , DVORNIKOVS VADIMS , ROSE PETER JAMISON
IPC: C07D471/00 , C07C51/00
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公开(公告)号：CA2797118C
公开(公告)日：2021-03-30
申请号：CA2797118
申请日：2011-04-21
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , HARRISON CRISTIAN , LITTLER BENJAMIN JOSEPH , ROSE PETER JAMISON , HUGHES ROBERT MICHAEL , JUNG YOUNG CHUN , SIESEL DAVID ANDREW , BELMONT DANIEL T , LEE ELAINE CHUNGMIN , NUGENT WILLIAM A
IPC: C07D209/12 , C07D405/12
Abstract: The present invention features processes for preparing a compound of formula III: (see formula III) compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-( 1 -hydroxy-2-methylpropan-2-yl)- 1 H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.
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公开(公告)号：HRP20210029T1
公开(公告)日：2021-03-19
申请号：HRP20210029
申请日：2021-01-08
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , NUGENT WILLIAM ALOYSIUS , DVORNIKOVS VADIMS , ROSE PETER JAMISON
IPC: C07D471/04 , C07C51/083
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公开(公告)号：AU2014348752B2
公开(公告)日：2019-02-28
申请号：AU2014348752
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , NUGENT WILLIAM ALOYSIUS , DVORNIKOVS VADIMS , ROSE PETER JAMISON
IPC: C07D471/04 , C07C51/083
Abstract: A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：NZ717669A
公开(公告)日：2017-09-29
申请号：NZ71766911
申请日：2011-04-21
Applicant: VERTEX PHARMA
Inventor： LEE ELAINE CHUNGMIN , HUGHES ROBERT MICHAEL , ROSE PETER JAMISON , TANOURY GERALD J , BELMONT DANIEL T , HARRISON CRISTIAN , SIESEL DAVID ANDREW , LITTLER BENJAMIN JOSEPH , JUNG YOUNG CHUN
IPC: C07D209/12
Abstract: intermediates for the preparation of Tezacaftor(VX-661) and its analogues. The intermediates are protecting group (P) bearing indole derivatives of formula III. the protecting group may be one of acetyl, benzoyl, benzyl, methoxyethoxymethyl, dimethoxytrityl, methoxymethyl, methoxytrityl, p-methoxybenzyl, pivaloyl, tetrahydropyranyl, trityl, or trimethylsilyl.
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Patent Agency Ranking
公开(公告)号：AU2012279046B2
公开(公告)日：2017-08-31
申请号：AU2012279046
申请日：2012-07-03
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , JUNG YOUNG CHUN , MAGDZIAK DEREK , LOOKER ADAM , KLINE BILLIE J , JURCIK VACLAV , DOMINGUEZ OLMO BEATRIZ
IPC: C07D471/04
Abstract: The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).
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公开(公告)号：CY1116278T1
公开(公告)日：2017-02-08
申请号：CY151100245
申请日：2015-03-12
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , CHEN MINZHANG , JONES ANDREW D , NYCE PHILIP L , TRUDEAU MARTIN , GUERIN DAVID J , SNOONIAN JOHN R
IPC: C07D405/12
Abstract: Ηεφεύρεσηαφοράσεμίαμέθοδοπαρασκευήςμίαςένωσηςπουπεριλαμβάνεικαθαρισμόμίγματος, όπου R8 είναιπροστατευτικήομάδακαιο καθαρισμόςπεριλαμβάνειχρωματογραφία, επιλεκτικώςκρυστάλλωσηή δυναμικώςκρυστάλλωσητουμίγματος.
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公开(公告)号：CY1114916T1
公开(公告)日：2016-12-14
申请号：CY141100149
申请日：2014-02-25
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , CHEN MINZHANG , COCHRAN JOHN E
IPC: C07D209/52 , A61K31/403 , C07D471/08
Abstract: Ηεφεύρεσηαφοράσεενώσειςκαιμεθόδουςχρήσιμεςγιατηνπαρασκευήαναστολέωνπρωτεάσης, ιδιαιτέρωςαναστολέωνπρωτεάσηςσερίνης. Οιαναστολείςπρωτεάσηςείναιχρήσιμοιγιατηνθεραπείαμολύνσεων HCV.
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公开(公告)号：SG10201505700QA
公开(公告)日：2015-08-28
申请号：SG10201505700Q
申请日：2011-04-21
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , HARRISON CRISTIAN , LITTLER BENJAMIN JOSEPH , ROSE PETER JAMISON , HUGHES ROBERT MICHAEL , JUNG YOUNG CHUN , SIESEL DAVID ANDREW , LEE ELAINE CHUNGMIN , BELMONT DANIEL T
Abstract: The present invention features processes for preparing compounds, such as ( R )-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.
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公开(公告)号：CA2930297A1
公开(公告)日：2015-05-21
申请号：CA2930297
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , NUGENT WILLIAM ALOYSIUS , DVORNIKOVS VADIMS , ROSE PETER JAMISON
IPC: C07D471/04 , C07C51/083
Abstract: A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.
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