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公开(公告)号：AU2008363828B2
公开(公告)日：2016-09-08
申请号：AU2008363828
申请日：2008-11-12
Applicant: VERTEX PHARMA
Inventor： RUAH SARA HADIDA S , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , MILLER MARK T , MCCARTNEY JASON , ZHOU JINGLAN , BEAR BRIAN , NUMA MEHDI MICHEL DJAMEL
IPC: C07D405/12 , A61K31/404 , A61P3/00 , A61P25/00
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：AU2010226393B2
公开(公告)日：2016-08-11
申请号：AU2010226393
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： YANG XIAOQING , HADIDA RUAH SARA S , GROOTENHUIS PETER D J , VAN GOOR FREDRICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233 , A61K31/47 , A61P3/00
Abstract: This invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R is COOH or CH
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公开(公告)号：AU2013205183B2
公开(公告)日：2016-07-28
申请号：AU2013205183
申请日：2013-04-14
Applicant: VERTEX PHARMA
Inventor： YANG XIAOQING , HADIDA RUAH SARA S , MCCARTNEY JASON , ZHOU JINGLAN , GOOR FREDRICK VAN , MILLER MARK T , NUMA MEHDI MICHEL JAMEL , BEAR BRIAN , GROOTENHUIS PETER D J
IPC: C07D405/12 , A61K31/404 , A61P31/00 , C07D405/14
Abstract: Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：AU2009282419B2
公开(公告)日：2016-05-19
申请号：AU2009282419
申请日：2009-08-13
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO
IPC: A61K47/32
Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- 3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
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公开(公告)号：BRPI1012549A2
公开(公告)日：2016-03-22
申请号：BRPI1012549
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： GOOR FREDRICK F VAN , ZLOKARNIK GREGOR , BOTFIELD MARTYN C , GROOTENHUIS PETER D J , RUAH SARA S HADIDA , YANG XIAOQING
IPC: A61K31/47 , A61P3/00 , C07D215/233
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Patent Agency Ranking
公开(公告)号：AU2009308284B2
公开(公告)日：2016-02-04
申请号：AU2009308284
申请日：2009-10-23
Applicant: VERTEX PHARMA
Inventor： BINCH HAYLEY , FANNING LEV T D , HURLEY DENNIS , SHETH URVI , SILINA ALINA , YANG XIAOQING , BOTFIELD MARTYN , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , NUMA MEHDI MICHEL DJAMEL
IPC: C07D451/02 , A61K31/439 , A61P11/00 , C07D453/04 , C12Q1/02
Abstract: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR. (l); or pharmaceutically acceptable salts thereof, wherein: ring A is selected from:
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公开(公告)号：SI2578571T1
公开(公告)日：2016-01-29
申请号：SI200831546
申请日：2008-11-14
Applicant: VERTEX PHARMA
Inventor： HADIDA RUAH SARA , MILLER MARK , ZHOU JINGLAN , BEAR BRIAN , GROOTENHUIS PETER D J
IPC: C07D217/00 , A61K31/00 , A61P11/00 , C07D401/00 , C07D405/00
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公开(公告)号：UA110192C2
公开(公告)日：2015-12-10
申请号：UAA201106976
申请日：2009-11-06
Applicant: VERTEX PHARMA
Inventor： RUAH SARA HADIDA S , GROOTENHUIS PETER D J , MILLER MARK T , MCCARTHEY JASON , VAN GOOR FREDRICK , NUMA MEHDI MICHEL DJAMEL , ZHOU JINGLAN , BEAR BRIAN
IPC: C07D405/12 , A61K31/404 , A61P3/00 , A61P25/00 , C07D209/08 , C07D209/12 , C07D209/18
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公开(公告)号：SI2007756T1
公开(公告)日：2015-11-30
申请号：SI200731695
申请日：2007-04-09
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , ZHOU JINGLAN , BEAR BRIAN , MILLER MARK T , MCCARTNEY JASON , NUMA MEHDI MICHEL JAMEL , YANG XIAOQING
IPC: C07D405/00 , A61K31/00 , A61P31/00
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公开(公告)号：DK2578571T3
公开(公告)日：2015-10-05
申请号：DK12181370
申请日：2008-11-14
Applicant: VERTEX PHARMA
Inventor： HADIDA RUAH SARA , MILLER MARK , ZHOU JINGLAN , BEAR BRIAN , GROOTENHUIS PETER D J
IPC: C07D217/22 , A61K31/472 , A61K31/4725 , A61P11/00 , C07D401/04 , C07D405/12 , C07D405/14
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