公开(公告)号：NO152129C

公开(公告)日：1985-08-07

申请号：NO821085

申请日：1982-03-31

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS DIETER ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS JOERG ,  DENGEL FERDINAND ,  FRANK WOLFRAM

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/75

公开(公告)号：FI844645A0

公开(公告)日：1984-11-27

申请号：FI844645

申请日：1984-11-27

Applicant: BASF AG

Inventor： RASCHACK MANFRED ,  KREISKOTT HORST ,  SEITZ WERNER

IPC: C07B57/00 ,  A61K20060101 ,  A61K31/275 ,  A61P9/00 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/42 ,  C07C255/58 ,  C07D20060101 ,  C07C

Abstract: 1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane and its antipodes and salts are used for the treatment of diseases.

公开(公告)号：ZA826832B

公开(公告)日：1983-08-31

申请号：ZA826832

申请日：1982-09-17

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  MUELLER JOSEF ,  LIETZ HELMUT ,  WIERSDORFF WALTER WIELANT ,  HEGE HANS GUENTHER ,  MUELLER CLAUS D ,  GRIES JOSEF ,  LENKE DIETER ,  PHILIPSBORN GERDA VON ,  RASCHACK MANFRED

IPC: A61K31/135 ,  A61K20060101 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/5375 ,  A61P9/06 ,  C07C20060101 ,  C07C67/00 ,  C07C213/00 ,  C07C217/36 ,  C07C225/22 ,  C07C323/25 ,  C07D207/06 ,  C07D211/44 ,  C07D211/52 ,  C07D295/08 ,  A61K ,  C07C

公开(公告)号：NO823161L

公开(公告)日：1983-03-21

申请号：NO823161

申请日：1982-09-17

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  MUELLER JOSEF ,  LIETZ HELMUT ,  WIERSDORFF WALTER-WIELANT ,  HEGE HANS-GUENTHER ,  MUELLER CLAUS D ,  GRIES JOSEF ,  LENKE DIETER ,  PHILIPSBORN GERDA VON ,  RASCHACK MANFRED

IPC: A61K31/13 ,  A61K31/445 ,  A61K31/495 ,  C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07D303/24 ,  C07C

Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.

公开(公告)号：NO823161A

公开(公告)日：1983-03-21

申请号：NO823161

申请日：1982-09-17

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  MUELLER JOSEF ,  LIETZ HELMUT ,  WIERSDORFF WALTER-WIELANT ,  HEGE HANS-GUENTHER ,  MUELLER CLAUS D ,  GRIES JOSEF ,  LENKE DIETER ,  PHILIPSBORN GERDA VON ,  RASCHACK MANFRED

IPC: C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D295/092 ,  C07D303/22 ,  C07D303/24 ,  C07C

CPC classification number: C07D295/088 ,  C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D303/22 ,  C07D303/24

公开(公告)号：NO821085A

公开(公告)日：1982-10-11

申请号：NO821085

申请日：1982-03-31

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS DIETER ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS JOERG ,  DENGEL FERDINAND ,  FRANK WOLFRAM

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C

CPC classification number: C07C255/00 ,  C07D317/58 ,  C07D317/60 ,  C07D319/18 ,  Y10S514/821 ,  Y10S514/927

公开(公告)号：FI820529L

公开(公告)日：1982-09-28

申请号：FI820529

申请日：1982-02-17

Applicant: BASF AG

Inventor： BINNIG FRITZ ,  MUELLER D CLAUS ,  RASCHACK MANFRED

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08 ,  C07D

Abstract: Bispidine derivatives of the formula I I where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds have antiarrhythmic properties.

公开(公告)号：DE19533023B4

公开(公告)日：2007-05-16

申请号：DE19533023

申请日：1995-09-07

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  KLINGE DAGMAR ,  AMBERG WILHELM ,  KLING ANDREAS ,  MUELLER STEFAN ,  BAUMANN ERNST ,  RHEINHEIMER JOACHIM ,  VOGELBACHER UWE JOSEF ,  WERNET WOLFGANG ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: C07D239/60 ,  C07D251/30 ,  A61K31/41 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  C07D239/00 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C07D239/38 ,  C07D239/70 ,  C07D239/96 ,  C07D251/12 ,  C07D251/52 ,  C07D257/02 ,  C07D309/00 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  C07D495/04

Abstract: Heterocyclyl-substd. propanoic acids and their derivs., of formula (I), are new. R = formyl, tetrazolyl, nitrile, COOH or a gp. that can be hydrolysed to COOH; X = N or CR14; R2 = H, OH, NH2, alkylamino, dialkylamino, halo, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; R14 = H or 1-5 C alkyl; R3 = R2 or alkoxyimino; or CR3 + CR14 = 5 or 6 membered alkylene or alkenyl ring (opt. substd. by 1-2 alkyl) in which a methylene can be replaced by O, S, NH or alkylamino; R4, R5 = phenyl or naphthyl (both opt. substd. by one or more halo, NO2, CN, OH, alkyl, haloalkyl, alkoxy, haloalkyloxy, phenoxy, alkylthio, NH2, alkylamine or dialkylamino) or 3-7 C cycloalkyl; or the phenyl or naphthyl gps. are opt. bonded at the O- position (by a bond, CH2, O, S, SO2, ethylene, ethenylene or opt. alkylated amino); R6 = H, 1-8 C alkyl, 2-6 C alkenyl, 3-6 C alkynyl, 3-8 C cycloalkyl (all opt. substd. by 1 or more halo, NO2, CN, alkoxy 3-6 C alkenyloxy, 3-6 C alkynyloxy, alkylthio, haloalkoxy, alkylcarbonyl, alkoxycarbonyl, 3-8 C alkylcarbonylalkyl, alkylamino, dialkylamino, phenyl, Ph or OPh), Ar or Het; Y = S, O or bond; Q = S, O, SO, SO2 or bond; Ph = substd. phenyl, where substits. are halo, NO2, CN, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; Ar = phenyl or naphthyl (both opt. substd. by 1 or more halo, NO2, CN, OH, NH2, alkylamino, dialkylamino or OCH2CH2O); Het = 5 or 6 membered heteroaromatic with 1-3 N atoms and/or one S or O (opt. substd. by 1-4 halo and/or 1 or 2 alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, phenyl, phenoxy or phenyl carbonyl (where the phenyl is opt. substd. by 1-5 halo and/or 1-3 alkyl, haloalkyl, alkoxy, haloalkoxy and/or alkylthio)); alkyl and alkoxy have 1-4 C unless otherwise stated; provided that R6 is not H when Q = bond.

公开(公告)号：SK8682001A3

公开(公告)日：2002-08-06

申请号：SK8682001

申请日：1999-12-09

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KETTSCHAU GEORG ,  RIECHERS HARTMUT ,  BAUMANN ERNST ,  HERGENRODER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: C07D251/24 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P15/10 ,  A61P35/00 ,  A61P43/00 ,  C07C229/34 ,  C07C233/87 ,  C07C235/52 ,  C07D239/34 ,  C07D251/22 ,  C07D401/12 ,  C07D491/048 ,  C07D239/60

Abstract: The invention relates to carboxylic acid derivatives of formula (I), in which the substituents have the following meanings: R is tetrazol or a group (a); W and Z, can be identical or different and are nitrogen or methine, provided that if W and Z are methine, then Q is nitrogen; X is nitrogen or CR ; Y is nitrogen or CR ; Q is nitrogen or CR , provided that if Q is nitrogen then X is CR and Y is CR ; R and R are identical or different and are possibly substituted phenyl or naphthyl or phenyl or naphthyl which are linked in an ortho position via a direct bond, a methlyene, ethylene or ethenylene group, an oxygen or sulfur atom or a SO2-, NH- or N-alkyl group or possibly substituted C5-C6-cycloalkyl; R is a rest (b) or (c); and R is hydrogen, C1-C4-alkyl. The invention further relates to their preparation and their use as endothelin receptor antagonists. The invention also relates to compounds of formula (II) and a structural fragment of formula (d) in which the rests R , R , R , R and R have the meanings given in claim no. 1 and to their use as structural elements in an endothelin receptor antagonist.

公开(公告)号：NO312674B1

公开(公告)日：2002-06-17

申请号：NO991079

申请日：1999-03-04

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61P9/04 ,  A61P9/08 ,  A61P9/12 ,  A61P43/00 ,  C07C59/66 ,  C07C69/734 ,  C07D239/34 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D491/04 ,  C07D491/048 ,  C07D237/34

Abstract: The invention relates to carboxylic acid derivatives of the formula Iwhere the radicals have the meanings stated in the description, and to their use as drugs.