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公开(公告)号：DE69720551T2
公开(公告)日：2004-02-26
申请号：DE69720551
申请日：1997-04-25
Applicant: ABBOTT LAB
Inventor： LARTEY A , CURTY BRUNELL , FAGHIH RAMIN , NELLANS NERBY , PETERSEN CHRISTIAN
IPC: A61K31/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P1/00 , A61P1/04 , A61P1/12 , A61P1/18 , A61P3/00 , A61P3/04 , A61P43/00 , C07H17/08
Abstract: Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having the Formula (I) (I) and pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.
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公开(公告)号：PT1021456E
公开(公告)日：2003-08-29
申请号：PT97922483
申请日：1997-04-25
Applicant: ABBOTT LAB
Inventor： LARTEY PAUL A , CURTY CYNTHIA BRUNELL , FAGHIH RAMIN , NELLANS HUGH NERNY , PETERSEN ALBERT CHRISTIAN
IPC: A61K31/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P1/00 , A61P1/04 , A61P1/12 , A61P1/18 , A61P3/00 , A61P3/04 , A61P43/00 , C07H17/08
Abstract: Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having the Formula (I) (I) and pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.
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公开(公告)号：AT236185T
公开(公告)日：2003-04-15
申请号：AT97922483
申请日：1997-04-25
Applicant: ABBOTT LAB
Inventor： LARTEY PAUL A , CURTY CYNTHIA BRUNELL , FAGHIH RAMIN , NELLANS HUGH NERBY , PETERSEN ALBERT CHRISTIAN
IPC: A61K31/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P1/00 , A61P1/04 , A61P1/12 , A61P1/18 , A61P3/00 , A61P3/04 , A61P43/00 , C07H17/08
Abstract: Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having the Formula (I) (I) and pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.
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公开(公告)号：AU7338401A
公开(公告)日：2002-01-30
申请号：AU7338401
申请日：2001-07-11
Applicant: ABBOTT LAB
Inventor： BENNANI YOUSSEF L , FAGHIH RAMIN , DWIGHT WESLEY J , VASUDEVAN ANIL , CONNER SCOTT E
IPC: C07D295/08 , A61K31/40 , A61K31/4025 , A61K31/4178 , A61K31/427 , A61K31/443 , A61K31/4439 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P3/04 , A61P9/10 , A61P11/06 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D207/06 , C07D207/12 , C07D207/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14
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公开(公告)号：CA2415396A1
公开(公告)日：2002-01-24
申请号：CA2415396
申请日：2001-07-11
Applicant: ABBOTT LAB
Inventor： DWIGHT WESLEY J , BENNANI YOUSSEF L , FAGHIH RAMIN , CONNER SCOTT E , VASUDEVAN ANIL
IPC: C07D295/08 , A61K31/40 , A61K31/4025 , A61K31/4178 , A61K31/427 , A61K31/443 , A61K31/4439 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P3/04 , A61P9/10 , A61P11/06 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D207/06 , C07D207/12 , C07D207/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14
Abstract: Compounds of formula (I) are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands. Also disclose d are histamine-3 receptor ligand compositions and methods of antagonizing or agonizing histamine-3 receptors.
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Patent Agency Ranking
公开(公告)号：DE69317877D1
公开(公告)日：1998-05-14
申请号：DE69317877
申请日：1993-01-19
Applicant: ABBOTT LAB
Inventor： LARTEY PAUL A , NELLANS HUGH N , KLEIN LARRY L , FAGHIH RAMIN
IPC: A61K31/70 , A61K31/7042 , A61K31/7048 , A61P1/00 , A61P1/08 , A61P1/10 , A61P31/04 , C07D233/22 , C07H17/08
Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.
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公开(公告)号：MX9300278A
公开(公告)日：1993-12-31
申请号：MX9300278
申请日：1993-01-19
Applicant: ABBOTT LAB
Inventor： LARTEY PAUL A , FAGHIH RAMIN , KLEIN LARRY L , NELLANS HUGH N
IPC: A61K31/70 , A61K31/7042 , A61K31/7048 , A61P1/00 , A61P1/08 , A61P1/10 , A61P31/04 , C07D233/22 , C07H17/08
Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.
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公开(公告)号：CA2125478A1
公开(公告)日：1993-07-22
申请号：CA2125478
申请日：1993-01-19
Applicant: ABBOTT LAB
Inventor： LARTEY PAUL A , NELLANS HUGH N , KLEIN LARRY L , FAGHIH RAMIN
IPC: A61K31/70 , A61K31/7042 , A61K31/7048 , A61P1/00 , A61P1/08 , A61P1/10 , A61P31/04 , C07D233/22 , C07H17/08
Abstract: 2125478 9313780 PCTABS00024 4''-Deoxy derivatives of erythromycin having formula (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.
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公开(公告)号：CA2566898C
公开(公告)日：2013-06-18
申请号：CA2566898
申请日：2005-04-29
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BLACK LAWRENCE A , CHANG SOU-JEN , COWART MARLON D , FAGHIH RAMIN , GFESSER GREGORY A , KU YI-YIN , LIU HUAQING , LUKIN KIRILL A , NERSESIAN DIANA L , PU YU-MING , CURTIS MICHAEL P
IPC: C07D513/04 , A61K31/4709 , A61K31/4725 , A61K31/519 , C07D401/00 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/02 , C07D471/04 , C07D487/04 , C07D491/02 , C07D491/04 , C07D495/04 , C07D498/02 , C07D498/04
Abstract: Compounds of formula (I) wherein R1 or R2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R1, R2, R3, R3a, R3b, R4, R5, L, X, X', Y, Y', Z, and Z' are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
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公开(公告)号：CA2415396C
公开(公告)日：2011-03-08
申请号：CA2415396
申请日：2001-07-11
Applicant: ABBOTT LAB
Inventor： BENNANI YOUSSEF L , FAGHIH RAMIN , DWIGHT WESLEY J , VASUDEVAN ANIL , CONNER SCOTT E
IPC: C07D207/12 , C07D295/08 , A61K31/40 , A61K31/4025 , A61K31/4178 , A61K31/427 , A61K31/443 , A61K31/4439 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P3/04 , A61P9/10 , A61P11/06 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D207/06 , C07D207/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14
Abstract: Compounds of formula (I) are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands. Also disclosed are histamine-3 receptor ligand compositions and methods of antagonizing or agonizing histamine-3 receptors.
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