公开(公告)号：DK172754B1

公开(公告)日：1999-06-28

申请号：DK276289

申请日：1989-06-06

Applicant: ABBOTT LAB

Inventor： PARIZA RICHARD J ,  LARTEY PAUL A ,  MARING CLARENCE J ,  KLEIN LARRY L

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  C07H19/04

Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

公开(公告)号：ES2115760T3

公开(公告)日：1998-07-01

申请号：ES93904533

申请日：1993-01-19

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  NELLANS HUGH N ,  KLEIN LARRY L ,  FAGHIH RAMIN

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P31/04 ,  C07D233/22 ,  C07H17/08

Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.

公开(公告)号：AT164848T

公开(公告)日：1998-04-15

申请号：AT93904533

申请日：1993-01-19

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  NELLANS HUGH N ,  KLEIN LARRY L ,  FAGHIH RAMIN

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P31/04 ,  C07D233/22 ,  C07H17/08

Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.

公开(公告)号：ZA977207B

公开(公告)日：1998-02-20

申请号：ZA977207

申请日：1997-08-12

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  KLEIN LARRY LEWIS ,  THOMAS SHEELA ALBERT ,  DEGOEY DA ALLEN ,  LI LEPING ,  LEONE CHRISTINA LOUISE ,  YEUNG MING CLIN ,  GRAMPOVNIK DAVID J

IPC: A61K38/00 ,  C07K7/56 ,  A61K ,  C07K

Abstract: Disclosed are novel antifungal agents having the formula: I or a pharmaceutically acceptable acid, ester or prodrug thereof, wherein preferred compounds include those compounds wherein R1 is selected from the group consisting of -NH2; R2 is selected from the group consisting of hydrogen, fluoro, and hydroxyl; R3 is selected from the group consisting of -CH2(p-C6H4)3O(CH2)3CH3, -CH2(p-C6H4)O(CH2)6CH3, -COO(p-C6H4)O(CH2)6CH3, -CO(Piperazinyl)(p-C6H4)2OCH3, -CO(p-C6H4)O(CH2)6CH3, -CO(p-C6H4)(Piperazinyl)(p-C6H4)O(CH2)4CH3, -CO(p-C6H4)(Piperazinyl)(p-C6H4)O(CH2)6CH3, -CO(p-C6H4)(Piperazinyl)(p-C6H4)OCH3, and -CO(p-C6H4)(Piperazinyl)O(CH2)6CH3; and R4 is selected from the group consisting of -CH(OH)CH3, -CH2OH, -CH2CH3, -CH2CH2CH2NH2, -CH2(CH2)NH2, -CH2NH2, -CH2(CH2)2(NH)C=(NH)-NH2, -CH3, -CH2(Ph)OH, hydrogen, -CH2CH2COOH, and -CH2COOH. Also disclosed are pharmaceutical compositions containing such compounds and the use of the same in the treatment of fungal infections.

公开(公告)号：GR3023617T3

公开(公告)日：1997-08-29

申请号：GR970401261

申请日：1997-05-30

Applicant: ABBOTT LAB

Inventor： PARIZA RICHARD J ,  MARING CLARENCE J ,  LARTEY PAUL A ,  KLEIN LARRY L

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  C07H19/04

Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

公开(公告)号：CA2208019A1

公开(公告)日：1996-07-18

申请号：CA2208019

申请日：1996-01-03

Applicant: ABBOTT LAB

Inventor： ALDER LISA A ,  KLEIN LARRY L ,  BURRES NEAL S ,  HOCHLOWSKI JILL E ,  LARTEY PAUL A ,  JACKSON MARIANNA ,  MCALPINE JAMES B ,  YEUNG CLINTON

IPC: C12P17/06 ,  A01N43/16 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  A61P31/10 ,  C07H15/10 ,  C07H17/04 ,  C12R1/645 ,  C12P19/44 ,  A61K31/71 ,  C07H13/06 ,  C07H13/08 ,  C12P7/62

Abstract: Novel antifungal agents having formula (I), wherein R is hydrogen or -C(O)-R1 wherein R1 is alkenyl, C2-C12-alkyl, aryl, arylalkenyl, arylalkyl, aryl-aryl-, arylalkoxy-aryl-, aryloxyl-aryl-, aryl-aryl-aryl- or arylalkoxy-aryl-aryl-, or pharmaceutically acceptable salts, esters or prodrugs thereof, as well as (i) pharmaceutical compositions comprising such compounds, (ii) methods of treatment using such compounds, and (iv) methods and fungal cultures useful in making the same.

公开(公告)号：ZA951845B

公开(公告)日：1996-03-15

申请号：ZA951845

申请日：1995-03-06

Applicant: ABBOTT LAB

Inventor： FAGHIH RAMIN ,  LARTEY PAUL A

IPC: A61K20060101 ,  A61K

公开(公告)号：ZA9501845B

公开(公告)日：1996-03-15

申请号：ZA9501845

申请日：1995-03-06

Applicant: ABBOTT LAB

Inventor： FAGHIH RAMIN ,  LARTEY PAUL A

IPC: A61K20060101 ,  A61K

公开(公告)号：DK276289A

公开(公告)日：1989-12-08

申请号：DK276289

申请日：1989-06-06

Applicant: ABBOTT LAB

Inventor： PARIZA RICHARD J ,  LARTEY PAUL A ,  MARING CLARENCE J ,  KLEIN LARRY L

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  C07H19/04

Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

公开(公告)号：PT1021456E

公开(公告)日：2003-08-29

申请号：PT97922483

申请日：1997-04-25

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  CURTY CYNTHIA BRUNELL ,  FAGHIH RAMIN ,  NELLANS HUGH NERNY ,  PETERSEN ALBERT CHRISTIAN

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P1/18 ,  A61P3/00 ,  A61P3/04 ,  A61P43/00 ,  C07H17/08

Abstract: Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having the Formula (I) (I) and pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.