公开(公告)号：CA2669917A1

公开(公告)日：2008-05-22

申请号：CA2669917

申请日：2007-11-16

Applicant: ABBOTT LAB

Inventor： GEORGE DAWN M ,  WISHART NEIL ,  DIXON RICHARD W ,  LI BIQIN ,  HOBSON ADRIAN ,  FRIEDMAN MICHAEL ,  WANG LU ,  WU XIAOYUN

IPC: C07D401/04 ,  A61K31/438 ,  A61K31/517 ,  C07D401/14

Abstract: The present invention is directed to novel aminopyrrolidines of formula ( I), pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, stereoisomers thereof or pro-drugs thereof, wherein the variables a re as defined herein. The compounds of formula (I) are useful as chemokine r eceptor antagonists and as such would be useful in treating certain conditio ns and diseases, especially inflammatory conditions and diseases and prolife rative disorders and conditions, for example, cancers.

公开(公告)号：CA2644910A1

公开(公告)日：2007-10-18

申请号：CA2644910

申请日：2007-04-02

Applicant: ABBOTT LAB

Inventor： ABBOTT LILY K ,  CUSACK KEVIN P ,  ARGIRIADI MARIA A ,  CALDERWOOD DAVID J ,  ZHANG XIAOLEI ,  MULLEN KELLY D ,  DIXON RICHARD W ,  GORDON THOMAS D ,  TALANIAN ROBERT V ,  WANG LU X ,  LI BIQIN ,  WU XIAOYUN ,  FRANK KRISTINE E ,  BORHANI DAVID W ,  ERICSSON ANNA M ,  BURCHAT ANDREW ,  WISHART NEIL ,  BARBERIS CLAUDE E

IPC: A61K31/5377

Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.