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公开(公告)号：WO2008005368A2
公开(公告)日：2008-01-10
申请号：PCT/US2007015192
申请日：2007-06-29
Applicant: ABBOTT LAB , BETSCHMANN PATRICK , CARROLL WILLIAM A , ERICSSON ANNA M , FIX-STENZEL SHANNON R , FRIEDMAN MICHAEL , HIRST GAVIN C , JOSEPHSOHN NATHAN S , LI BIQIN , PEREZ-MEDRANO ARTURO , MORYTKO MICHAEL J , RAFFERTY PAUL , CHEN HAIPENG
Inventor： BETSCHMANN PATRICK , CARROLL WILLIAM A , ERICSSON ANNA M , FIX-STENZEL SHANNON R , FRIEDMAN MICHAEL , HIRST GAVIN C , JOSEPHSOHN NATHAN S , LI BIQIN , PEREZ-MEDRANO ARTURO , MORYTKO MICHAEL J , RAFFERTY PAUL , CHEN HAIPENG
IPC: A61K31/496
CPC classification number: C07D241/04 , C07D241/36 , C07D295/215 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04
Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, enantiomers thereof or prodrugs thereof of Formula (I), wherein the substituents are as defined herein, which are useful as therapeutic agents.
Abstract translation: 式（I）的新型化合物或其药学上可接受的盐，其代谢物，其异构体，其对映异构体或其前体药物，其中取代基如本文所定义，其可用作治疗剂。
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公开(公告)号：EP2299821A4
公开(公告)日：2012-02-08
申请号：EP09763424
申请日：2009-06-09
Applicant: ABBOTT LAB
Inventor： WISHART NEIL , ARGIRIADI MARIA A , CALDERWOOD DAVID J , ERICSSON ANNA M , FIAMENGO BRYAN A , FRANK KRISTINE E , FRIEDMAN MICHAEL , GEORGE DAWN M , GOEDKEN ERIC R , JOSEPHSOHN NATHAN S , LI BIQIN C , MORYTKO MICHAEL J , STEWART KENT D , VOSS JEFFREY W , WALLACE GRIER A , WANG LU , WOLLER KEVIN R
IPC: A01N43/42 , C07D487/14 , C07D498/14 , C07D513/14
CPC classification number: C07D487/14 , C07D498/14 , C07D513/14
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公开(公告)号：WO2008060621A2
公开(公告)日：2008-05-22
申请号：PCT/US2007024076
申请日：2007-11-16
Applicant: ABBOTT LAB , GEORGE DAWN M , DIXON RICHARD W , FRIEDMAN MICHAEL , HOBSON ADRIAN , LI BIQIN , WANG LU , WU XIAOYUN , WISHART NEIL
Inventor： GEORGE DAWN M , DIXON RICHARD W , FRIEDMAN MICHAEL , HOBSON ADRIAN , LI BIQIN , WANG LU , WU XIAOYUN , WISHART NEIL
IPC: C07D471/04 , A61K31/4375 , A61K31/438 , A61K31/454 , C07D401/04
CPC classification number: A61K31/454 , A61K31/437 , A61K31/438 , A61K31/4545 , A61K31/4709 , A61K31/4747 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/55 , A61K31/553 , C07D207/14 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D487/14
Abstract: The present invention is directed to novel aminopyrrolidines of formula I, pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, stereoisomers thereof or pro-drugs thereof, wherein the variables are as defined herein. The compounds of formula (I) are useful as chemokine receptor antagonists and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
Abstract translation: 本发明涉及式I的新型氨基吡咯烷，其药学上可接受的盐，其代谢物，其异构体，其立体异构体或其前体药物，其中变量如本文所定义。 式（I）化合物可用作趋化因子受体拮抗剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性疾病和病症，例如癌症。
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公开(公告)号：WO2005074603A2
公开(公告)日：2005-08-18
申请号：PCT/US2005003196
申请日：2005-02-03
Applicant: ABBOTT LAB , WISHART NEIL , FRIEDMAN MICHAEL , ARNOLD LEE D , YANG BRYANT , FIX-STENZEL SHANNON R , ERICSSON ANNA , MICHAELIDES MICHAEL R , QIAN XIAO-DONG , HOLMES JAMES H , STEINMAN DOUGLAS H , TIAN ZHENGPING , WITTENBERGER STEVEN J
Inventor： WISHART NEIL , FRIEDMAN MICHAEL , ARNOLD LEE D , YANG BRYANT , FIX-STENZEL SHANNON R , ERICSSON ANNA , MICHAELIDES MICHAEL R , QIAN XIAO-DONG , HOLMES JAMES H , STEINMAN DOUGLAS H , TIAN ZHENGPING , WITTENBERGER STEVEN J
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: A compound of Formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.
Abstract translation: 式（I）的化合物，其中取代基如本文所定义，其可用作激酶抑制剂。
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公开(公告)号：EP2506716A4
公开(公告)日：2013-05-29
申请号：EP10835061
申请日：2010-12-01
Applicant: ABBOTT LAB
Inventor： WISHART NEIL , ARGIRIADI MARIA A , CALDERWOOD DAVID J , ERICSSON ANNA M , FIAMENGO BRYAN A , FRANK KRISTINE E , FRIEDMAN MICHAEL , GEORGE DAWN M , GOEDKEN ERIC R , JOSEPHSOHN NATHAN S , LI BIQIN C , MORYTKO MICHAEL J , STEWART KENT D , VOSS JEFFREY W , WALLACE GRIER A , WANG LU , WOLLER KEVIN R
IPC: C07D487/14 , A61K31/437 , A61K31/4985 , A61P19/00 , C07D471/14 , C07D498/14 , C07D513/14
CPC classification number: C07D487/14 , A61K31/437 , A61K31/4985 , A61K45/06 , C07D471/14 , C07D498/14 , C07D513/14
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Patent Agency Ranking
公开(公告)号：EP2099454A4
公开(公告)日：2010-11-10
申请号：EP07867491
申请日：2007-11-16
Applicant: ABBOTT LAB
Inventor： GEORGE DAWN M , DIXON RICHARD W , FRIEDMAN MICHAEL , HOBSON ADRIAN , LI BIQIN , WANG LU , WU XIAOYUN , WISHART NEIL
IPC: A61K31/445 , C07D211/00
CPC classification number: A61K31/454 , A61K31/437 , A61K31/438 , A61K31/4545 , A61K31/4709 , A61K31/4747 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/55 , A61K31/553 , C07D207/14 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D487/14
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公开(公告)号：EP1730148A4
公开(公告)日：2009-08-19
申请号：EP05722668
申请日：2005-02-03
Applicant: ABBOTT LAB
Inventor： WISHART NEIL , FRIEDMAN MICHAEL , ARNOLD LEE D , YANG BRYANT , FIX-STENZEL SHANNON R , ERICSSON ANNA , MICHAELIDES MICHAEL R , QIAN XIAO-DONG , HOLMES JAMES H , STEINMAN DOUGLAS H , TIAN ZHENGPING , WITTENBERGER STEVEN J
IPC: C07D487/04 , A61K31/381 , A61K31/519 , A61K31/5377 , C07D239/70 , C07D263/54 , C07D295/03 , C07D513/06
CPC classification number: C07D487/04
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公开(公告)号：PE20140407A1
公开(公告)日：2014-04-25
申请号：PE2013001090
申请日：2009-06-09
Applicant: ABBOTT LAB
Inventor： WISHART NEIL , ARGIRIADI MARIA A , CALDERWOOD DAVID J , ERICSSON ANNA M , FIAMENGO BRYAN A , FRANK KRISTINE E , FRIEDMAN MICHAEL , GEORGE DAWN M , GOEDKEN ERIC R , JOSEPHSOHN NATHAN S , LI BIQIN C , MORYTKO MICHAEL J , STEWART KENT D , VOSS JEFFREY W , WALLACE GRIER A , WANG LU , WOLLER KEVIN R
IPC: C07D487/14 , A61K31/4985 , A61P35/00 , C07D498/14 , C07D513/14
Abstract: REFERIDA A UN COMPUESTO TRICICLICO DE FORMULA (I), DONDE T ES CR6, N, O, NR6, S; U ES N, CR4; X ES CR3, NR3; Y ES N O C; R1, R2 Y R5 SON H, HALOGENO, NO2, CN, ENTRE OTROS; R3 ES H, CICLOALQUILO C5-C12, ARILO C6-C10, ENTRE OTROS; R4 Y R6 SON H, HALOGENO, CICLOALQUILO C5-C12, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-((3R,4R)-3-(6H-IMIDAZO[1,5-a]PIRROLO[2,3-e]PIRAZIN-1-IL)-4-METILPIPERIDIN-1-IL)-3-OXOPROPANONITRILO, 7-(5-METOXI-1-METIL-1H-INDOL-3-IL)-1-METIL-6H-IMIDAZO[1,5-a]PIRROLO[2,3-e]PIRAZINA, 1-CICLOHEXIL-6H-IMIDAZO[1,5-a]PIRROLO[2,3-e]PIRAZINA, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES INMUNOLOGICAS Y ONCOLOGICAS
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公开(公告)号：CR20120294A
公开(公告)日：2012-09-03
申请号：CR20120294
申请日：2012-05-30
Applicant: ABBOTT LAB
Inventor： WISHART NEIL , ARGIRIADI MARIA A , BRENINLINGER ERIC C , CALDERWOOD DAVID J , ERICSSON ANNA M , FIAMENGO BRYAN A , FRANK KRISTINE E , FRIEDMAN MICHAEL , GEORGE DAWN M , GOEDKEN ERIC R , JOSEPHSOHN NATHAN S , LI BIQIN C , MORYTKO MICHAEL J , MULLEN KELLY D , SOMAL GAGANDEEP , STEWART KENT D , VOSS JEFFREY W , WALLACE GRIER A , WANG LU , WOLLER KEVIN R
Abstract: Un compuesto con la Fórmula (Ia), (Ib), (Ic), (Id), (Ie), (Si), (Ig), (Ih), (Ii), (Ij), (Ik), o (Il), según se las define aquí, sales farmacéuticamente aceptables, prodrogas, metabolitos, estereoisómeros e isómeros de los mismos biológicamente activos, donde las variables se han definido aquí. Los compuestos de la invención son útiles para tratar condiciones inmunológicas y oncológicas.
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公开(公告)号：ECSP10010657A
公开(公告)日：2011-02-28
申请号：ECSP10010657
申请日：2010-12-03
Applicant: ABBOTT LAB
Inventor： WOLLER KEVIN ROGER , WISHART NEIL , FRIEDMAN MICHAEL , CALDERWOOD DAVID , ARGIRIADI MARIA A , WALLACE GRIER A , ERICSSON ANNA M , FIAMENGO BRYAN A , FRANK KRISTINE E , GEORGE DAWN M , GOEDKEN ERIK R , JOSEPHSOHN NATHAN S , LI BIQIN C , MORYTKO MICHAEL J , STEWART KENT D , VOSS JEFFREY W , WANG LU
IPC: A01N43/42
Abstract: La invención proporciona un compuesto de la Formula (I)Formula (I)sales farmacéuticamente aceptables, metabolitos biológicamente activos, estereoisómeros eisómeros de estos en donde las variables están definidas en este documento. Los compuestos de la invención son útiles para el tratamiento de condiciones inmunológicas y oncológicas.
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