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公开(公告)号：ZA9801301B
公开(公告)日：1998-08-28
申请号：ZA9801301
申请日：1998-02-17
Applicant: ABBOTT LAB
Inventor： WASICAK JAMES T , GARVEY DAVID S , HOLLADAY MARK W , LIN NAN-HORNG , RYTHER KEITH B
IPC: A61P25/04 , A61K31/422 , A61K31/4439 , A61K31/4725 , A61P25/00 , A61P43/00 , C07D487/04 , C07D , A61K
CPC classification number: C07D487/04
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公开(公告)号：AU5601098A
公开(公告)日：1998-07-03
申请号：AU5601098
申请日：1997-12-10
Applicant: ABBOTT LAB
Inventor： HOLLADAY MARK W , ARNERIC STEPHEN P , BAI HAO , DART MICHAEL J , LIN NAN-HORNG , LYNCH JOHN K , OR YAT SUN , RYTHER KEITH B , SULLIVAN JAMES P , WASICAK JAMES T , EHRLICH PAUL P
IPC: A61P25/04 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/485 , A61P25/28 , A61P29/00 , C07D205/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/44
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
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23.发明专利
公开(公告)号：NZ545789A
公开(公告)日：2010-03-26
申请号：NZ54578904
申请日：2004-09-17
Applicant: ABBOTT LAB
Inventor： BASHA ANWER , BUNNELLE WILLIAM H , DART MICHAEL J , GALLAGHER MEGAN E , JI JIANGUO , PACE JENNIFER M , RYTHER KEITH B , TIETJE KARIN R , MORTELL KATHLEEN H , NERSESIAN DIANA L , SCHRIMPF MICHAEL R , LI TAO
IPC: C07D471/04 , A61K31/435 , A61P25/00 , C07D471/08 , C07D487/04 , C07D487/08
Abstract: Disclosed are diazabicycloalkane derivatives of formula (I), wherein the substituents are defined as per the specification. The compounds are useful in treating conditions or disorders prevented by or ameliorated by alpha-7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and the use such compounds and compositions for the preparation of medicaments for the treatment of such disorders.
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公开(公告)号：DOP2008000060A
公开(公告)日：2009-01-15
申请号：DO2008000060
申请日：2008-11-27
Applicant: ABBOTT LAB
Inventor： DART MICHAEL J , CARROLL WILLIAM A , FLORJANCIC ALAN S , FROST JENNIFER M , GALLAGHER MEGAN E , LI TONGMEI , NELSON DEREK W , PATEL MEENA V , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , RYTHER KEITH B , ROSEMARIE KARIN , TEODZYJ
Abstract: Compuestos de la fórmula (1), o sales farmacéuticas, prodrogas, sales de prodrogas, o combinaciones de los mismos, donde R1, R2, R3, R4, y Li se definen en la memoria descriptiva, composiciones que comprenden dichos compuestos, y métodos para tratar condiciones y trastornos usando dichos compuestos y composiciones. La presente invención también se refiere a compuestos de fórmula (II), o sales farmacéuticas, prodrogas, sales de prodrogas, o combinaciones de los mismos, donde Ria, R23 y (R) tienen los valores definidos en la memoria descriptiva, composiciones que comprenden dichos compuestos, y métodos para tratar condiciones y trastornos usando dichos compuestos y composiciones.
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公开(公告)号：NO20085385A
公开(公告)日：2008-12-29
申请号：NO20085385
申请日：2008-12-29
Applicant: ABBOTT LAB
Inventor： RYTHER KEITH B , KOLASA TEODOZYJ , PATEL MEENA V , DART MICHAEL J , CARROLL WILLIAM A , FLORJANCIC ALAN S , FROST JENNIFER M , GALLAGHER MEGAN E , LI TONGMEI , NELSON DEREK W , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , TIETJE KARIN ROSEMARIE
IPC: C07D277/28
CPC classification number: C07D277/82 , C07D277/46 , C07D277/48 , C07D277/60 , C07D417/06 , C07D417/12 , C07D477/14 , C07D513/04
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Patent Agency Ranking
公开(公告)号：MX2008015217A
公开(公告)日：2008-12-12
申请号：MX2008015217
申请日：2007-05-30
Applicant: ABBOTT LAB
Inventor： PEREZ-MEDRANO ARTURO , DART MICHAEL J , GALLAGHER MEGAN E , RYTHER KEITH B , CARROLL WILLIAM A , FLORJANCIC ALAN S , NELSON DEREK W , KOLASA TEODOZYJ , PATEL MEENA V , LI TONGMEI , FROST JENNIFER M , PEDDI SRIDHAR , TIETJE KARIN ROSEMARIE
IPC: C07D277/46 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , A61P29/00 , C07D277/48 , C07D277/60 , C07D277/82 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: La presente invención se refiere a compuesto de la fórmula (I), o sales farmacéuticas, profármacos, sales de profármacos, o combinaciones de los mismo, en donde R1, R2, R3, R4, y L1 se definen en la memoria descriptiva, composiciones que comprenden dichos compuestos, y métodos para tratar condiciones y trastornos usando dichos compuestos y composiciones. La presente invención también se refiere a compuestos de fórmula (II), o sales farmacéuticas, profármacos, sales de profármacos, o combinaciones de los mismos, en donde R1a, R2a y (Rx)n son como se definen en la memoria descriptiva, composiciones que comprenden dichos compuestos, y métodos para tratar condiciones y trastornos usando dichos compuestos y composiciones.
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公开(公告)号：HU225894B1
公开(公告)日：2007-12-28
申请号：HU0202034
申请日：2000-05-15
Applicant: ABBOTT LAB
Inventor： SCHRIMPF MICHAEL R , SIPPY KEVIN B , DAANEN JEROME F , RYTHER KEITH B , JI JIANGUO
IPC: C07D491/048 , A61K31/00 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K45/00 , A61P25/00 , A61P25/04 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , C07D401/04 , C07D495/04
Abstract: Heterocyclic substituted aminoazacyclic compounds of the formula (I):Z-R3, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
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公开(公告)号：CA2647597A1
公开(公告)日：2007-12-06
申请号：CA2647597
申请日：2007-05-30
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , FLORJANCIC ALAN S , PATEL MEENA V , FROST JENNIFER M , DART MICHAEL J , TIETJE KARIN ROSEMARIE , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , RYTHER KEITH B , NELSON DEREK W , KOLASA TEODOZYJ , LI TONGMEI , GALLAGHER MEGAN E
IPC: C07D277/46 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , A61P29/00 , C07D277/48 , C07D277/60 , C07D277/82 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
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公开(公告)号：AU773795B2
公开(公告)日：2004-06-03
申请号：AU2856900
申请日：2000-01-25
Applicant: ABBOTT LAB
Inventor： BUNNELLE WILLIAM H , CRISTINA DANIELA BARLOCCO , DAANEN JEROME F , DART MICHAEL J , MEYER MICHAEL D , RYTHER KEITH B , SCHRIMPF MICHAEL R , SIPPY KEVIN B , TOUPENCE RICHARD B
IPC: A61K31/00 , A61K31/407 , A61K31/4355 , A61K31/4365 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/502 , A61P9/10 , A61P15/10 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/048 , C07D495/04 , C07D519/00 , A61K31/395
Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2 and CH2CH2; Z is selected from the group consisting of CH2 and CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.
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公开(公告)号：NZ512884A
公开(公告)日：2004-03-26
申请号：NZ51288400
申请日：2000-01-25
Applicant: ABBOTT LAB
Inventor： BUNNELLE WILLIAM H , SIPPY KEVIN B , TOUPENCE RICHARDB , RYTHER KEITH B , SCHRIMPF MICHAEL R , CRISTINA DANIELABARLOCCO , DAANEN JEROME F , DART MICHAEL J , MEYER MICHAELD
IPC: A61K31/00 , A61K31/407 , A61K31/4355 , A61K31/4365 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/502 , A61P9/10 , A61P15/10 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/048 , C07D495/04 , C07D519/00 , A61K31/395
Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2, and CH2CH2; Z is selected from the group consisting of CH2, CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.
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