公开(公告)号：EP2344505A2

公开(公告)日：2011-07-20

申请号：EP09793046.5

申请日：2009-09-28

Applicant: Abbott Laboratories

Inventor： SCHRIMPF, Michael R. ,  LEE, Chih-Hung ,  LI, Tao ,  GFESSER, Gregory A. ,  MORTELL, Kathleen H. ,  FAGHIH, Ramin ,  NERSESIAN, Diana L. ,  SIPPY, Kevin B. ,  BUNNELLE, William H. ,  SCANIO, Marc ,  SHI, Lei ,  GOPALAKRISHNAN, Murali ,  DONNELLY-ROBERTS, Diana ,  HU, Min

IPC: C07D487/18 ,  A61K31/33 ,  A61P25/00

CPC classification number: G01N33/5058 ,  C07D471/18 ,  C07D487/10 ,  C07D487/18 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/30

Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R
1 , R
2 , R
3 , R
4 , R
5 , U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

公开(公告)号：EP2297140A1

公开(公告)日：2011-03-23

申请号：EP08770247.8

申请日：2008-06-06

Applicant: Abbott Laboratories

Inventor： JI, Jianguo ,  LEE, Chih-Hung ,  SIPPY, Kevin, B. ,  LI, Tao ,  GOPALAKRISHNAN, Murali

IPC: C07D413/04 ,  C07D271/06

CPC classification number: C07D271/06 ,  A61K31/495 ,  A61K45/06 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  A61K2300/00

Abstract: The invention relates to 1,2,4 oxadiazole compounds and analogs thereof, represented by formula (II), and compositions and methods of use thereof.

公开(公告)号：EP1658269A1

公开(公告)日：2006-05-24

申请号：EP04754996.9

申请日：2004-06-10

Applicant: ABBOTT LABORATORIES

Inventor： GOMTSYAN, Arthur ,  BAYBURT, Erol, K. ,  LEE, Chih-Hung ,  KOENIG, John, R. ,  SCHMIDT, Robert ,  LUKIN, Kirill ,  CHAMBOURNIER, Gilles ,  HSU, Margaret ,  LEANNA, M., Robert ,  CINK, Russel, D.

IPC: C07D217/02 ,  C07D231/56 ,  C07D403/12 ,  C07D401/12 ,  C07C211/42 ,  A61K31/472 ,  A61K31/416 ,  A61P13/10

CPC classification number: C07D403/12 ,  C07D217/02 ,  C07D231/56 ,  C07D401/12

Abstract: The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt or prodrug thereof (in which X1 - X5, R5 - R8b, Z1 - Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.

公开(公告)号：EP1885704B1

公开(公告)日：2011-09-28

申请号：EP06759574.4

申请日：2006-05-10

Applicant: ABBOTT LABORATORIES

Inventor： GOMTSYAN, Arthur ,  PERNER, Richard ,  KOENIG, John ,  HSU, Margaret Chi-Ping ,  FERNANDO, Dilini ,  LEE, Chih-Hung

IPC: C07D263/48 ,  A61K31/421 ,  A61P29/00

CPC classification number: C07D263/48

Abstract: The present invention is directed to compounds of formula (I) (I) wherein variables W, X, Y, D, A, n, R1, R2 and R9 are as defined in the description.

公开(公告)号：EP2231657A1

公开(公告)日：2010-09-29

申请号：EP08852111.7

申请日：2008-11-20

Applicant: Abbott Laboratories

Inventor： JI, Jianguo ,  LI, Tao ,  SIPPY, Kevin B ,  LEE, Chih-Hung ,  GOPALAKRISHNAN, Murali

IPC: C07D451/04 ,  C07D451/06 ,  A61K31/46 ,  A61P25/00

CPC classification number: C07D451/04 ,  A61K31/46 ,  C07D451/06

Abstract: The invention relates to biaryl substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP0979230A1

公开(公告)日：2000-02-16

申请号：EP98917950.2

申请日：1998-04-16

Applicant: Abbott Laboratories

Inventor： BHAGWAT, Shripad, S. ,  LEE, Chih-Hung ,  PERNER, Richard, J. ,  GU, Yu-Gui

IPC: C07D471/04 ,  A61K31/505

CPC classification number: C07D471/04

Abstract: A compound having formula (I), wherein R?1, R2, R3 and R4¿ are defined variables selected from the groups as specified herein which include alkyl, aryl, heteroaryl and heterocyclic and substituted versions thereof, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above in combination with a pharmaceutically acceptable carrier, a method of treating cerebral ischemia, epilepsy, nociperception, pain, inflammation and sepsis in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound thereof, and methods of preparation thereof.

公开(公告)号：EP2134678A2

公开(公告)日：2009-12-23

申请号：EP07855088.6

申请日：2007-12-12

Applicant: ABBOTT LABORATORIES

Inventor： GOMTSYAN, Arthur R. ,  SCHMIDT, Robert G. ,  DAANEN, Jerome F. ,  BAYBURT, Erol K. ,  LEE, Chih-Hung ,  LATSHAW, Steven P.

IPC: C07C275/32 ,  C07D311/58 ,  C07D215/42 ,  A61K31/17 ,  A61K31/353 ,  A61K31/47 ,  A61P25/04

CPC classification number: C07C275/32 ,  C07D215/12 ,  C07D215/42 ,  C07D215/54 ,  C07D311/58 ,  C07D311/74

Abstract: The present application is directed to compounds that are TRPV1 antagonists and have formula: (I); wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.

公开(公告)号：EP1478363B1

公开(公告)日：2009-01-14

申请号：EP03716014.0

申请日：2003-02-11

Applicant: ABBOTT LABORATORIES

Inventor： LEE, Chih-Hung ,  BAYBURT, Erol, K. ,  DIDOMENICO, Stanley Jr. ,  DRIZIN, Irene ,  GOMTSYAN, Arthur, R. ,  KOENIG, John R. ,  PERNER, Richard, J. ,  SCHMIDT, Robert G. ,  TURNER, Sean C. ,  WHITE, Tammie, K. ,  ZHENG, Guo, Zhu

IPC: A61K31/502 ,  C07D217/02 ,  C07D237/28 ,  C07D217/22 ,  C07D209/08 ,  C07D231/56 ,  A61K31/472 ,  A61K31/416 ,  A61K31/404

CPC classification number: C07D249/08 ,  A61K31/404 ,  A61K31/416 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  C07D209/08 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D217/26 ,  C07D231/12 ,  C07D231/56 ,  C07D233/56 ,  C07D237/28 ,  C07D401/12 ,  C07D405/12

Abstract: Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.

公开(公告)号：EP1836200A1

公开(公告)日：2007-09-26

申请号：EP05853514.7

申请日：2005-12-07

Applicant: ABBOTT LABORATORIES

Inventor： BROWN, Brian, S. ,  KEDDY, Ryan, G. ,  LEE, Chih-Hung

IPC: C07D417/04 ,  A61K31/425

CPC classification number: C07D451/02 ,  C07D275/06 ,  C07D417/04

Abstract: Compounds having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein L, A, G, R1, R2 and R3 are as defined herein. These compounds are particularly useful in the treatment of pain, inflammatory hyperalgesia, and urinary dysfunctions, such as bladder overactivity and urinary incontinence.

公开(公告)号：EP1658269B1

公开(公告)日：2008-10-22

申请号：EP04754996.9

申请日：2004-06-10

Applicant: ABBOTT LABORATORIES

Inventor： GOMTSYAN, Arthur ,  BAYBURT, Erol, K. ,  LEE, Chih-Hung ,  KOENIG, John, R. ,  SCHMIDT, Robert ,  LUKIN, Kirill ,  CHAMBOURNIER, Gilles ,  HSU, Margaret ,  LEANNA, M., Robert ,  CINK, Russel, D.

IPC: C07D217/02 ,  C07D231/56 ,  C07D403/12 ,  C07D401/12 ,  C07C211/42 ,  A61K31/472 ,  A61K31/416 ,  A61P13/10

CPC classification number: C07D403/12 ,  C07D217/02 ,  C07D231/56 ,  C07D401/12

Abstract: The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt or prodrug thereof (in which X1 - X5, R5 - R8b, Z1 - Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.