公开(公告)号：AT220897T

公开(公告)日：2002-08-15

申请号：AT98965716

申请日：1998-11-30

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN ,  MEFFERT HELMUT ,  BERNDL GUNTHER ,  ERNST ANDREAS ,  SANNER AXEL

IPC: A61K47/32 ,  A23K20/10 ,  A23K40/10 ,  A23K40/20 ,  A23L27/00 ,  A23L33/10 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K31/277 ,  A61K31/421

Abstract: Solid dosage forms are obtained by mixing at least one polymeric binder, at least one active ingredient, and, where appropriate, conventional additives to form a plastic mixture, and shaping, using as polymeric binder a copolymer of an N-vinyllactam and a copolymerizable monomer having a hydrophobic radical. Dosage forms which show slow release of the active ingredient are obtained in a simple and low-cost manner.

公开(公告)号：CA2343259A1

公开(公告)日：2001-10-06

申请号：CA2343259

申请日：2001-04-05

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  BREITENBACH JORG ,  KESSEL KNUT ,  SCHERR GUNTER ,  BOGENSTATTER THOMAS

IPC: A61K9/20 ,  A61K31/198 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61P3/02 ,  A61P21/00 ,  C08K5/29 ,  C08L101/00

Abstract: a) a mixture which comprises at least one thermoplastic, physiologically tolerated, water-soluble or water-swellable polymeric binder and creatine, and contains 1 to 20 mol of water per mol of creatine is prepared, b) the mixture is plasticated at or above the softening point of the polymeric binder, preferably with at least partial evaporation of the water, c) the plasticated mixture is shaped to dosage forms and cooled.

公开(公告)号：CA2367020A1

公开(公告)日：2000-09-21

申请号：CA2367020

申请日：2000-03-10

Applicant: BASF AG

Inventor： SIMON DIRK ,  REINHOLD ULRICH ,  LEHMANN STEPHAN ,  BERNDL GUNTHER

IPC: A01N25/08 ,  A01N25/10 ,  A61K8/73 ,  A61K8/86 ,  A61K9/20 ,  A61K9/22 ,  A61K31/192 ,  A61K31/565 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/40 ,  A61K47/48 ,  A61Q19/00

Abstract: The invention relates to a method for producing solid dosage forms containin g at least one physiologically compatible polymer binding agent, at least one active agent and at least one cyclodextrin as components. According to the method, the components are mixed and plasticised at a temperature below 220 ~C, without the addition of a solvent. The plastic mixture obtained is shape d into the dosage form. The invention also relates to the dosage forms obtaine d by said method.

公开(公告)号：DE19900457A1

公开(公告)日：2000-07-13

申请号：DE19900457

申请日：1999-01-08

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN ,  NGUYEN KIM SON ,  BERNDL GUNTHER ,  SANNER AXEL

IPC: A61K9/16 ,  A61K9/20 ,  A61K9/28

Abstract: The invention relates to a method for producing solid dosage forms by forming a plastic mixture of at least one polymer binding agent, at least one active ingredient and possibly usual additives, which mixture is then shaped. The invention is characterized in that a water-swellable polyurethane having a glass transition temperature Tg >/= 20 DEG C is used as the polymer binding agent.

公开(公告)号：NO20000486L

公开(公告)日：2000-01-31

申请号：NO20000486

申请日：2000-01-31

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  BREITENBACH JOERG

IPC: A23K40/10 ,  A23K40/20 ,  A23K50/80 ,  A23K1/18 ,  A23K1/00

Abstract: The invention relates to slow sinking, porous granules or pellets with a density of greater than 1 g/cm for use in fish breeding. The inventive granules or pellets are obtained by solvent-free melt extrusion of mixtures consisting of biologically active substances, matrix support substances and a solid gas producer.

公开(公告)号：AU3930399A

公开(公告)日：1999-12-06

申请号：AU3930399

申请日：1999-05-04

Applicant: BASF AG

Inventor： HEGER ROBERT ,  AUWETER HELMUT ,  PFLUGER PETER ,  BREITENBACH JORG ,  BINDER RUDOLF ,  ZEIDLER JURGEN ,  BERNDL GUNTHER

IPC: A61K9/16 ,  A61K9/51 ,  A61K38/00 ,  A61K38/13 ,  A61K47/14 ,  A61K47/36 ,  A61P37/06 ,  A61K9/00

公开(公告)号：DE19812688A1

公开(公告)日：1999-09-30

申请号：DE19812688

申请日：1998-03-23

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN ,  BERNDL GUNTHER ,  SIMON DIRK ,  SANNER AXEL

IPC: A23L33/00 ,  A61K9/20 ,  A61K9/22 ,  A61K47/32 ,  A61K47/34 ,  C08F279/02 ,  C08L51/04

Abstract: Solid dosage forms contain a water-swellable graft copolymer (I) as binder. An Independent claim is also included for the production of solid dosage forms by mixing (I) with active ingredient(s) and optionally additives, preferably in an extruder, and shaping the resulting plastic mixture.

公开(公告)号：DE19811919A1

公开(公告)日：1999-09-23

申请号：DE19811919

申请日：1998-03-18

Applicant: BASF AG

Inventor： MEFFERT HELMUT ,  SANNER AXEL ,  BERNDL GUNTHER ,  RUCHATZ FOLKER ,  KOLTER KARL ,  BAUER KURT HEINZ

IPC: A61K8/63 ,  A61K9/00 ,  A61K9/107 ,  A61K9/20 ,  A61K9/48 ,  A61K47/32 ,  C08F220/04

Abstract: New copolymers (I) are derived from: (a) 82-99.9 mol.% 3-8C mono-ethylenically unsaturated carboxylic acid(s) (II); (b) 0.1-18 mol.% of at least one of the N-(8-30C alkyl) amides of monoethylenically unsaturated 3-8C carboxylic acids, N,N-di-(8-30C alkyl) amides of monoethylenically unsaturated 3-8C carboxylic acids and 8-30C alkyl esters of monoethylenically unsaturated 3-8C carboxylic acids (II); and (c) 0-17.9 mol.% of one or more of vinyl esters of 8-30C aliphatic carboxylic acids and 8-30C alkyl-vinyl ethers. The preparation of (I) is also claimed.

公开(公告)号：ZA976363B

公开(公告)日：1999-01-19

申请号：ZA976363

申请日：1997-07-18

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/16 ,  A61K9/20 ,  A61K36/00 ,  A61K36/16 ,  A61K36/38 ,  A61K36/48 ,  A61K36/61 ,  A61K

公开(公告)号：BRPI0009299B1

公开(公告)日：2011-05-17

申请号：BRPI0009299

申请日：2000-03-17

Applicant: BASF AG

Inventor： LIEPOLD BERND ,  ROSENBERG JOERG ,  BERNDL GUNTHER ,  BREITENBACH JOERG

IPC: A61K47/10 ,  A61K9/16 ,  A61K9/20 ,  A61K47/14 ,  A61K47/34 ,  A61P31/10 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00

Abstract: The present invention relates to mechanically stable pharmaceutical presentations for oral administration, comprising in addition to one or more active ingredients and at least one melt-processable matrix-forming excipient more than 10 and up to 40% by weight of a surface-active substance with an HLB of from 2 to 18, which is liquid at 20° C. or has a drop point in the range from 20 to 50° C.