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21.发明专利
公开(公告)号：MX9802153A
公开(公告)日：1998-08-30
申请号：MX9802153
申请日：1998-03-19
Applicant: BASF AG
Inventor： BREITENBACH JOERG , HAERTL AXEL PAUL , HOFMANN JUERGEN , ROSENBERG JOERG , SCHIESSL MICHAEL , ZETTLER HANS DIETER
IPC: A61J3/10 , A61K9/20 , A61K9/24 , A61K9/28 , A61K31/07 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/355 , A61K31/375 , A61K31/401 , A61K31/4422 , A61K31/52 , A61K31/522 , A61K31/60
Abstract: La presente invencion se refiere a un proceso para producir formas de medicamentos solidas de multiples capas para administracion oral o rectal, el cual consiste en la coextrusion de por lo menos dos composiciones las cuales en cada caso contienen un aglutinante polimérico farmacologicamente aceptable, termoplástico, que es soluble o esponjable en un medio fisiologico y por lo menos una de las cuales contiene un ingrediente farmacéutico activo, y la formacion del material de multiples capas coextruido en la forma de medicamento requerida.
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22.发明专利
公开(公告)号：CZ124298A3
公开(公告)日：1998-07-15
申请号：CZ124298
申请日：1996-10-23
Applicant: BASF AG
Inventor： BREITENBACH JORG DR , HARTL AXEL PAUL DR , HOFMANN JURGEN , ROSENBERG JOERG DR , SCHIESSL MICHAEL , ZETTLER HANS DIETER
IPC: A61J3/10 , A61K9/20 , A61K9/24 , A61K9/28 , A61K31/07 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/355 , A61K31/375 , A61K31/401 , A61K31/4422 , A61K31/52 , A61K31/522 , A61K31/60
Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.
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公开(公告)号：PL325059A1
公开(公告)日：1998-07-06
申请号：PL32505996
申请日：1996-08-19
Applicant: BASF AG
Inventor： LAY PETER NIKOLAUS , RUECK SWEN , SCHIESSL MICHAEL , WITT MICHAEL , ZETTLER HANS DIETER , BAUMGAERTEL MICHAEL , DEMBEK GERHARD , HAHN KLAUS , HOLOCH JAN , HUSEMANN WOLFRAM , KAEMPFER KNUT
Abstract: PCT No. PCT/EP96/03633 Sec. 371 Date Jan. 29, 1998 Sec. 102(e) Date Jan. 29, 1998 PCT Filed Aug. 19, 1996 PCT Pub. No. WO97/08231 PCT Pub. Date Mar. 6, 1997A continuous process for preparing bead-form expandable styrene polymers in which the styrene is prepolymerized in bulk to a conversion of 10 to 80%, the prepolymer is dispersed in liquid form in an aqueous phase in the presence of suspension stabilizers, and the polymerization of the prepolymer is completed in an aqueous suspension to a residual styrene content of less than 2000 ppm.
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公开(公告)号：NO981798A
公开(公告)日：1998-04-22
申请号：NO981798
申请日：1998-04-22
Applicant: BASF AG
Inventor： BREITENBACH JAERG , HORTL AXEL PAUL , ROSENBERG JOERG , SCHIESSL MICHAEL , ZETTLER HANS DIETER
CPC classification number: A61K9/1694 , A61K9/2095
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公开(公告)号：CA2232357A1
公开(公告)日：1997-05-01
申请号：CA2232357
申请日：1996-10-22
Applicant: BASF AG
Inventor： BREITENBACH JOERG , H RTL AXEL PAUL , SCHIESSL MICHAEL , ZETTLER HANS DIETER , ROSENBERG JOERG
IPC: A61K9/16 , A61K9/20 , A61J3/06 , A61K31/19 , A61K31/275 , A61K31/40 , A61K31/455 , A61K31/60 , A61K47/32 , A61K47/38
Abstract: The invention concerns a method of producing medicaments in solid form by mixing at least one pharmacologically acceptable polymer binder, at least one pharmaceutical active substance and optionally conventional pharmaceutical additives, extruding the mixture and shaping the medicament, a pre-mixture being prepared from the components and fed into the extruder. The method according to the invention enables high-quality medicaments to be produced in a simple and careful manner.
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Patent Agency Ranking
公开(公告)号：DE59001780D1
公开(公告)日：1993-07-22
申请号：DE59001780
申请日：1990-10-08
Applicant: BASF AG
Inventor： PFISTER JUERGEN DR , SCHIESSL MICHAEL , NACHTRAB RAINER
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27.发明专利
公开(公告)号：CA2232356C
公开(公告)日：2005-08-23
申请号：CA2232356
申请日：1996-10-23
Applicant: BASF AG
Inventor： ZETTLER HANS DIETER , HOFMANN JURGEN , ROSENBERG JOERG , HARTL AXEL PAUL , BREITENBACH JORG , SCHIESSL MICHAEL
IPC: A61J3/10 , A61K9/20 , A61K9/24 , A61K9/28 , A61K31/07 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/355 , A61K31/375 , A61K31/401 , A61K31/4422 , A61K31/52 , A61K31/522 , A61K31/60 , A61K9/02 , A61K31/19 , A61K31/275 , A61K31/40 , A61K31/455
Abstract: The invention concerns a method of producing multi-layer medicaments in soli d form for oral or rectal administration. At least two substances, which each comprise a thermoplastic, pharmacologically acceptable polymer binder which is soluble or can swell in a physiological environment, at least one of the substances comprising a pharmaceutical active substance, are coextruded and the coextruded multi-layer material is shaped to form the desired medicament.
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公开(公告)号：ES2175139T3
公开(公告)日：2002-11-16
申请号：ES96937214
申请日：1996-10-23
Applicant: BASF AG
Inventor： BREITENBACH JORG , HARTL AXEL PAUL , HOFMANN JURGEN , ROSENBERG JOERG , SCHIESSL MICHAEL , ZETTLER HANS DIETER
IPC: A61J3/10 , A61K9/20 , A61K9/24 , A61K9/28 , A61K31/07 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/355 , A61K31/375 , A61K31/401 , A61K31/4422 , A61K31/52 , A61K31/522 , A61K31/60
Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.
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公开(公告)号：PT857062E
公开(公告)日：2002-09-30
申请号：PT96937214
申请日：1996-10-23
Applicant: BASF AG
Inventor： ROSENBERG JOERG , ZETTLER HANS DIETER , BREITENBACH JOERG , HAERTL AXEL PAUL , HOFMANN JUERGEN , SCHIESSL MICHAEL
IPC: A61J3/10 , A61K9/20 , A61K9/24 , A61K9/28 , A61K31/07 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/355 , A61K31/375 , A61K31/401 , A61K31/4422 , A61K31/52 , A61K31/522 , A61K31/60
Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.
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公开(公告)号：ES2133196T3
公开(公告)日：1999-09-01
申请号：ES96928475
申请日：1996-08-19
Applicant: BASF AG
Inventor： LAY PETER NIKOLAUS , RUCK SWEN , SCHIESSL MICHAEL , WITT MICHAEL , ZETTLER HANS DIETER , BAUMGARTEL MICHAEL
Abstract: PCT No. PCT/EP96/03633 Sec. 371 Date Jan. 29, 1998 Sec. 102(e) Date Jan. 29, 1998 PCT Filed Aug. 19, 1996 PCT Pub. No. WO97/08231 PCT Pub. Date Mar. 6, 1997A continuous process for preparing bead-form expandable styrene polymers in which the styrene is prepolymerized in bulk to a conversion of 10 to 80%, the prepolymer is dispersed in liquid form in an aqueous phase in the presence of suspension stabilizers, and the polymerization of the prepolymer is completed in an aqueous suspension to a residual styrene content of less than 2000 ppm.
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