公开(公告)号：PT716705E

公开(公告)日：2000-09-29

申请号：PT94927528

申请日：1994-09-01

Applicant: BASF AG ,  RHEIN BIOTECH PROZ & PROD GMBH

Inventor： JANOWICZ ZBIGNIEW A ,  PIORKOWSKI MICHAEL J ,  SCHWEDEN JUERGEN ,  BOLLSCHWEILER CLAUS ,  WEYDEMANN ULRIKE ,  STRASSER ALEXANDER W M

IPC: C12N15/09 ,  C07K14/815 ,  C12N1/19 ,  C12N9/34 ,  C12N15/62 ,  C12N15/81 ,  C12P21/02 ,  C12R1/78

Abstract: PCT No. PCT/EP94/02897 Sec. 371 Date Mar. 1, 1996 Sec. 102(e) Date Mar. 1, 1996 PCT Filed Sep. 1, 1994 PCT Pub. No. WO95/07356 PCT Pub. Date Mar. 16, 1995A process for the recombinant production of proteins in the yeast Hansenula comprises transforming Hansenula with an expression cassette which comprises the following structural elements encoded: L-A-P-GEN where L is a leader sequence, A is an adaptor producing an alpha-helix structure, P is a processing signal and GEN is a structural gene for the required protein.

公开(公告)号：ZA9701107B

公开(公告)日：1998-08-11

申请号：ZA9701107

申请日：1997-02-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  HOEFFKEN HANS WOLFGANG ,  SCHWEDEN JUERGEN ,  RUEBSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  C07K ,  A61K ,  C07H

CPC classification number: C12N9/6429 ,  A61K38/00 ,  C12Y304/21005

公开(公告)号：CA2245546A1

公开(公告)日：1997-08-14

申请号：CA2245546

申请日：1997-02-11

Applicant: BASF AG

Inventor： H FFKEN HANS WOLFGANG ,  SCHWEDEN JUERGEN ,  RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  RUEBSAMEN KLAUS ,  SCHMIDT MARTIN ,  BOLLSCHWEILER CLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  A61K38/48

Abstract: The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment ArgAsp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：LV5809A4

公开(公告)日：1997-02-20

申请号：LV960306

申请日：1996-07-22

Applicant: BASF AG

Inventor： KURFUERST MANFRED ,  RUEBSAMEN KLAUS ,  SCHMIED BERNHARD ,  KOERWER WOLFGANG ,  SCHWEDEN JUERGEN ,  HOEFFKEN HANS W

IPC: A61K38/58 ,  A61K47/48 ,  C07K14/815 ,  C07K17/08

公开(公告)号：DE59010205D1

公开(公告)日：1996-04-18

申请号：DE59010205

申请日：1990-11-22

Applicant: BASF AG

Inventor： KURFUERST MANFRED ,  RUEBSAMEN KLAUS ,  SCHMIED BERNHARD ,  KOERWER WOLFGANG ,  SCHWEDEN JUERGEN ,  HOEFFKEN HANS

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/58 ,  A61K47/48 ,  A61P7/02 ,  C07K14/815 ,  C07K17/08 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19

Abstract: PCT No. PCT/EP90/01998 Sec. 371 Date May 29, 1992 Sec. 102(e) Date May 29, 1992 PCT Filed Nov. 22, 1990 PCT Pub. No. WO91/08229 PCT Pub. Date Jun. 13, 1991Hirudin/polyalkylene glycol derivatives of the formula[A-(CH2)n-[O-(CH2)nlm-B-]p Hir [sic]I and hirudin muteins and the preparation thereof are described. The compounds are suitable for controlling diseases.

公开(公告)号：CA2067224A1

公开(公告)日：1991-06-02

申请号：CA2067224

申请日：1990-11-22

Applicant: BASF AG

Inventor： KURFUERST MANFRED ,  RUEBSAMEN KLAUS ,  SCHMIED BERNHARD ,  KOERWER WOLFGANG ,  SCHWEDEN JUERGEN ,  HOEFFKEN HANS W

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/58 ,  A61K47/48 ,  A61P7/02 ,  C07K14/815 ,  C07K17/08 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  C07K17/06

Abstract: Hirudin/polyalkylene glycol derivatives of the formula (A-(CH2)n-[O-(CH2)n]m-B-]p Hir [sic] I and hirudin muteins and the preparation thereof are described. The compounds are suitable for controlling diseases.

公开(公告)号：GR3036938T3

公开(公告)日：2002-01-31

申请号：GR20010401806

申请日：2001-10-18

Applicant: BASF AG

Inventor： SCHWEDEN JUERGEN ,  ECKES PETER ,  HORNBERGER WILFRIED ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.

公开(公告)号：PL346059A1

公开(公告)日：2002-01-14

申请号：PL34605900

申请日：2000-06-07

Applicant: BASF AG

Inventor： RADEMACHER WILHELM ,  KRAEMER KLAUS ,  SCHWEDEN JUERGEN ,  HERBERS KARIN

IPC: A23K1/14 ,  A23L1/30 ,  A61K8/96 ,  A61K8/97 ,  A01H5/00 ,  A61K36/00 ,  A61K36/18 ,  A61K36/23 ,  A61K36/48 ,  A61K36/73 ,  A61K36/75 ,  A61K36/81 ,  A61K36/896 ,  A61K36/899 ,  A61P1/14 ,  A61P3/06 ,  A61P29/00 ,  A61P35/00 ,  A61P39/06 ,  A61P43/00 ,  A61Q19/00 ,  C12N5/10 ,  C12N9/02 ,  C12N15/09 ,  C12N15/29 ,  C12N15/53 ,  C12N15/82 ,  C12N15/52 ,  A01H1/00 ,  A61K31/35

Abstract: The invention relates to a method for increasing flavonoid content in plants. Said method is characterized that a plant is produced using molecular genetic methods in which the activity of enzyme flavanon-3-hydroxylase is reduced.

公开(公告)号：DK0730473T3

公开(公告)日：2001-10-08

申请号：DK95901432

申请日：1994-11-25

Applicant: BASF AG

Inventor： SCHWEDEN JUERGEN ,  SUBKOWSKI THOMAS ,  ECKES PETER ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.

公开(公告)号：CA2067224C

公开(公告)日：2001-02-13

申请号：CA2067224

申请日：1990-11-22

Applicant: BASF AG

Inventor： KURFUERST MANFRED ,  RUEBSAMEN KLAUS ,  SCHMIED BERNHARD ,  KOERWER WOLFGANG ,  SCHWEDEN JUERGEN ,  HOEFFKEN HANS W

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/58 ,  A61K47/48 ,  A61P7/02 ,  C07K14/815 ,  C07K17/08 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  C07K17/06

Abstract: Hirudin/polyalkylene glycol derivatives of the formula (A-(CH2)n-¢O-(CH2)n!m-B-!p Hir ¢sic! I and hirudin muteins and the preparation thereof are described. The compounds are suitable for controlling diseases.