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公开(公告)号：CA2472438A1
公开(公告)日：2004-01-08
申请号：CA2472438
申请日：2003-06-30
Applicant: FUSO PHARMACEUTICAL IND
Inventor： SAKAMOTO TAKASHI , KESHI HIROYUKI , OHTANI KATSUKI , KISHI YUICHIRO , WAKAMIYA NOBUTAKA
Abstract: It is intended to disclose an anti-HIV agent which contains as the active ingredient a mannose-binding protein (MBP) and efficaciously contributes to the treatment of patients infected with human immunodeficiency virus (HIV) a nd inhibits the progress of the disease. It is also intended to disclose a meth od of evaluating an anti-HIV activity exerted by the MBP which involves the ste p of culturing HIV-infected cells in the presence of the MBP.
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公开(公告)号：DE69331443D1
公开(公告)日：2002-02-14
申请号：DE69331443
申请日：1993-08-10
Applicant: FUSO PHARMACEUTICAL IND
Inventor： MATSUHISA AKIO , SHIBA KIYOTAKA , MIKAWA YOSHIKAZU , KISHI YUICHIRO
IPC: C12Q1/68 , C12Q1/6813 , C12Q1/6816 , G01N27/447 , G01N33/50 , G01N33/58 , C12Q1/28 , C12Q1/42
Abstract: A method of detecting a nucleic acid which comprises bringing a solid carrier suspected to carry or contain a nucleic acid into contact with a polyamine containing, bound thereto, a label capable of generating a detectable signal or a precursor thereof to thereby form a complex between a nucleic acid, if any, and the polyamine, removing the polyamine which has not formed any complex before or after the conversion of the precursor, if used, into the label, and detecting the label.
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公开(公告)号：AT211770T
公开(公告)日：2002-01-15
申请号：AT95907490
申请日：1993-08-10
Applicant: FUSO PHARMACEUTICAL IND
Inventor： MATSUHISA AKIO , SHIBA KIYOTAKA , MIKAWA YOSHIKAZU , KISHI YUICHIRO
IPC: C12Q1/68 , C12Q1/6813 , C12Q1/6816 , G01N27/447 , G01N33/50 , G01N33/58 , C12Q1/28 , C12Q1/42
Abstract: A method of detecting a nucleic acid which comprises bringing a solid carrier suspected to carry or contain a nucleic acid into contact with a polyamine containing, bound thereto, a label capable of generating a detectable signal or a precursor thereof to thereby form a complex between a nucleic acid, if any, and the polyamine, removing the polyamine which has not formed any complex before or after the conversion of the precursor, if used, into the label, and detecting the label.
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公开(公告)号：AU3680000A
公开(公告)日：2001-10-30
申请号：AU3680000
申请日：2000-04-17
Applicant: FUSO PHARMACEUTICAL IND
Inventor： TANAKA TOSHIO , SUGATANI JUNKO , KISHI YUICHIRO , MATSUKAWA AKIRA
IPC: A61K31/7072 , A61K31/7076 , A61P7/02 , A61P9/06 , A61P9/10 , A61P43/00 , C07H19/10 , C07H19/20 , C07H19/067 , C07H19/167
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公开(公告)号：JPH0965898A
公开(公告)日：1997-03-11
申请号：JP22336095
申请日：1995-08-31
Applicant: FUSO PHARMACEUTICAL IND
Inventor： UEMURA HIDETOSHI , KISHI YUICHIRO , YOSHIDA HIROSHI
Abstract: PROBLEM TO BE SOLVED: To obtain a new nucleotide having a specific base sequence or such a sequence that part of the base(s) on the 5' side, 3' side or the sides other than these ends are deleted from or added to the above base sequence, and useful as e.g. a primer for identifying Chlamydia microbial species by PCR process. SOLUTION: This new nucleotide has a base sequence of the formula, or is obtained by deleting one or two bases from the end of the 5' side or 3' side of the sequence, adding -T or -TA to the end above, substituting other base(s) for one or two bases on sides other than the above-mentioned both sides or modifying at least one of these bases. This new nucleotide is useful as e.g. a primer for identifying Chlamydia microbial species by making use of PCR process. This new nucleotide is obtained by chemical synthesis of part of the outer membrane protein gene of a kind of Chlamydia microbe (e.g. Chlamydia trachomatis), and the objective identification is carried out based on the restriction enzyme digestive pattern of the amplified product by PCR process using this nucleotide.
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Patent Agency Ranking
公开(公告)号：JPH07255499A
公开(公告)日：1995-10-09
申请号：JP4911694
申请日：1994-03-18
Applicant: FUSO PHARMACEUTICAL IND
Inventor： ARAKI MASAHIRO , UEMURA HIDETOSHI , KISHI YUICHIRO , YOSHIDA HIROSHI
Abstract: PURPOSE:To differentiate the serum type by conducting a PCR reaction using a part of a gene coding the main outer membrane protein of Chlamydia trachomatis as a primer, searching the amplified product from the reaction solution, digesting it and comparing the resultant substances. CONSTITUTION:A PCR reaction is conducted by using a nucleotide represented by formulae I to IV, etc., or a sequence obtained by applying one or more modifications thereto, e.g. eliminating one or two bases from the 5' side terminal, eliminating one or two bases from the 3' side terminal, adding G or GG to the terminal or substituting one or two bases except both the terminal with another base among A, C, G, T, etc., and composed of a part of a gene coding the main adventitial protein of Chlamydia trachomatis as a primer. The amplified product derived from this gene is searched out from the reaction solution and the searched out product is digested by a restriction enzyme. The size of the DNA fragment of the digested material is analyzed and compared, thus differentiating the serum type of a microorganism, Chlamydia trachomatis.
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公开(公告)号：ES2281413T3
公开(公告)日：2007-10-01
申请号：ES01922014
申请日：2001-04-23
Applicant: FUSO PHARMACEUTICAL IND
Inventor： WAKAMIYA NOBUTAKA , KESHI HIROYUKI , OHTANI KATSUKI , SAKAMOTO TAKASHI , KISHI YUICHIRO
IPC: C07K14/47 , A01K67/027 , C07K14/785 , C07K16/18 , C12N15/12 , C12P21/02 , G01N33/53
Abstract: Una proteína que comprende una secuencia amino-acídica que consiste en 245 aminoácidos expuestos en la posición aminoacídica 1-245 de la SEQ ID NO: 4.
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公开(公告)号：DE69628039T2
公开(公告)日：2004-03-18
申请号：DE69628039
申请日：1996-09-04
Applicant: FUSO PHARMACEUTICAL IND
Inventor： NAKAZAWA TERUKI , ARAKI HIROMASA , KISHI YUICHIRO , SHINODA SANJI , YAMADA MORIYUKI , OHASHI KAZUTOMO
IPC: A01K67/02 , A01K67/027 , C12N5/02 , C12N5/073 , C12N5/00
Abstract: The present invention aims to provide a medium composition for in vitro fertilization, in particular, a composition usable in the culture of ova or early embryos which are fertilized eggs, the preparation or culture of sperm, and the pre-treatment of ova or sperm. The composition comprises, as its essential components, L-phenylalanine, L-tryptophan, L-lysine, L-threonine, L-valine, L-methionine, L-isoleucine, L-leucine, L-proline, glycine, L-alanine, L-tyrosine, L-histidine, L-arginine, L-taurine, L-aspartic acid, L-serine, L-asparagine, L-glutamic acid, L-glutamine and L-cystine, provided that at least a part of the L-cystine may be replaced by L-cysteine.
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公开(公告)号：AU2003246119A1
公开(公告)日：2004-01-19
申请号：AU2003246119
申请日：2003-06-30
Applicant: FUSO PHARMACEUTICAL IND
Inventor： WAKAMIYA NOBUTAKA , OHTANI KATSUKI , SAKAMOTO TAKASHI , KESHI HIROYUKI , KISHI YUICHIRO
Abstract: Disclosed are anti-HIV agents which comprise a mannose binding protein (MBP) as an active component and are useful for effectively inhibiting progress of diseases state in and useful in therapy for individuals infected with human immunodeficiency virus (HIV). Also disclosed are a method for evaluating an anti-HIV activity of MBP comprising the step of culturing HIV infected cells under the presence of MBP.
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公开(公告)号：AT239364T
公开(公告)日：2003-05-15
申请号：AT96929521
申请日：1996-09-04
Applicant: FUSO PHARMACEUTICAL IND
Inventor： NAKAZAWA TERUKI , ARAKI HIROMASA , KISHI YUICHIRO , SHINODA SANJI , YAMADA MORIYUKI , OHASHI KAZUTOMO
IPC: A01K67/02 , A01K67/027 , C12N5/02 , C12N5/073 , C12N5/00
Abstract: The present invention aims to provide a medium composition for in vitro fertilization, in particular, a composition usable in the culture of ova or early embryos which are fertilized eggs, the preparation or culture of sperm, and the pre-treatment of ova or sperm. The composition comprises, as its essential components, L-phenylalanine, L-tryptophan, L-lysine, L-threonine, L-valine, L-methionine, L-isoleucine, L-leucine, L-proline, glycine, L-alanine, L-tyrosine, L-histidine, L-arginine, L-taurine, L-aspartic acid, L-serine, L-asparagine, L-glutamic acid, L-glutamine and L-cystine, provided that at least a part of the L-cystine may be replaced by L-cysteine.
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