公开(公告)号：NO903532D0

公开(公告)日：1990-08-10

申请号：NO903532

申请日：1990-08-10

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG ,  SCHOELKENS BERNWARD ,  SCHOLZ WOLFGANG ,  WIEMER GABRIELE ,  URBACH HANSJOERG ,  HENNING RAINER ,  TEETZ VOLKER

IPC: A61K38/55 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07C237/12 ,  C07K5/06 ,  A61K

Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I (I) in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each is hydrogen or an organic radical, and R4 and R5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angiotensin converting enzyme inhibitors and to agents containing these for administration for the treatment of the abovementioned diseases.

公开(公告)号：NO893524A

公开(公告)日：1990-03-05

申请号：NO893524

申请日：1989-09-01

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH ,  HENNING RAINER ,  RUEGER WOLFGANG ,  LERCH ULRICH ,  URBACH HANSJOERG ,  HOCK FRANZ ,  WIEMER GABRIELE

IPC: A61K31/495 ,  A61P25/00 ,  A61P25/28 ,  C07D241/08 ,  C07D403/04 ,  C07D405/04 ,  C07D455/04 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D513/04 ,  C07K1/113 ,  C07K5/06

CPC classification number: C07D487/04 ,  C07D241/08

公开(公告)号：HUT45486A

公开(公告)日：1988-07-28

申请号：HU557487

申请日：1987-12-10

Applicant: HOECHST AG

Inventor： KUNSTMANN RUDOLF ,  HOCK FRANZ ,  WIEMER GABRIELE

IPC: C07D209/14 ,  A61K31/165 ,  A61K31/195 ,  A61K31/215 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P25/18 ,  A61P25/28 ,  C07C231/00 ,  C07C231/02 ,  C07C237/04 ,  C07C237/20 ,  C07C237/22 ,  C07D209/16 ,  C07D211/14 ,  C07D211/30 ,  C07D211/70 ,  C07D295/14 ,  C07D295/15 ,  C07D307/66 ,  C07D307/82 ,  C07D333/20 ,  C07D333/58 ,  C07C103/32 ,  C07D207/02 ,  C07D213/04 ,  C07D209/04 ,  C07D307/78 ,  C07D335/04 ,  C07D307/34 ,  C07D335/02 ,  A61K31/16 ,  A61K31/38

Abstract: Aminopropionic acid amides of the formula I in which A, X and Z have the meanings indicated, and their physiologically tolerable salts are used as medicaments in which these compounds in particular have nootropic action.

公开(公告)号：DE3642497A1

公开(公告)日：1988-06-23

申请号：DE3642497

申请日：1986-12-12

Applicant: HOECHST AG

Inventor： KUNSTMANN RUDOLF DR ,  HOCK FRANZ DR ,  WIEMER GABRIELE

IPC: C07D209/14 ,  A61K31/165 ,  A61K31/195 ,  A61K31/215 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P25/18 ,  A61P25/28 ,  C07C231/00 ,  C07C231/02 ,  C07C237/04 ,  C07C237/20 ,  C07C237/22 ,  C07D209/16 ,  C07D211/14 ,  C07D211/30 ,  C07D211/70 ,  C07D295/14 ,  C07D295/15 ,  C07D307/66 ,  C07D307/82 ,  C07D333/20 ,  C07D333/58 ,  C07C103/50 ,  C07D295/12 ,  C07D213/74 ,  C07D207/337 ,  C07D307/54 ,  C07D307/81 ,  C07D333/24 ,  C07D333/60 ,  A61K31/16

Abstract: Aminopropionic acid amides of the formula I in which A, X and Z have the meanings indicated, and their physiologically tolerable salts are used as medicaments in which these compounds in particular have nootropic action.

公开(公告)号：PT86344A

公开(公告)日：1988-01-01

申请号：PT8634487

申请日：1987-12-11

Applicant: HOECHST AG

Inventor： KUNSTMANN RUDOLF ,  HOCK FRANZ ,  WIEMER GABRIELE

IPC: C07D209/14 ,  A61K31/165 ,  A61K31/195 ,  A61K31/215 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P25/18 ,  A61P25/28 ,  C07C231/00 ,  C07C231/02 ,  C07C237/04 ,  C07C237/20 ,  C07C237/22 ,  C07D209/16 ,  C07D211/14 ,  C07D211/30 ,  C07D211/70 ,  C07D295/14 ,  C07D295/15 ,  C07D307/66 ,  C07D307/82 ,  C07D333/20 ,  C07D333/58 ,  C07C103/00

Abstract: Aminopropionic acid amides of the formula I in which A, X and Z have the meanings indicated, and their physiologically tolerable salts are used as medicaments in which these compounds in particular have nootropic action.

公开(公告)号：NO875181D0

公开(公告)日：1987-12-11

申请号：NO875181

申请日：1987-12-11

Applicant: HOECHST AG

Inventor： KUNSTMANN RUDOLF ,  HOCK FRANZ ,  WIEMER GABRIELE

IPC: C07D209/14 ,  A61K31/165 ,  A61K31/195 ,  A61K31/215 ,  A61K31/34 ,  A61K31/341 ,  A61K31/343 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P25/18 ,  A61P25/28 ,  C07C231/00 ,  C07C231/02 ,  C07C237/04 ,  C07C237/20 ,  C07C237/22 ,  C07D209/16 ,  C07D211/14 ,  C07D211/30 ,  C07D211/70 ,  C07D295/14 ,  C07D295/15 ,  C07D307/66 ,  C07D307/82 ,  C07D333/20 ,  C07D333/58 ,  C07D295/00

Abstract: Aminopropionic acid amides of the formula I in which A, X and Z have the meanings indicated, and their physiologically tolerable salts are used as medicaments in which these compounds in particular have nootropic action.

公开(公告)号：AU665093B2

公开(公告)日：1995-12-14

申请号：AU4163793

申请日：1993-06-30

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  WIEMER GABRIELE ,  WAGNER ADALBERT ,  KLEEMANN HEINZ-WERNER

IPC: A61K31/40 ,  A61K31/00 ,  A61K31/41 ,  A61K31/415 ,  A61K31/435 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61K45/00 ,  A61P9/08 ,  A61P9/10 ,  A61P25/28 ,  A61P37/00 ,  C07D207/32 ,  C07D233/84 ,  C07D233/90 ,  C07D255/02 ,  C07D257/04 ,  C07D403/10 ,  C07D471/04

公开(公告)号：NO932390A

公开(公告)日：1994-01-03

申请号：NO932390

申请日：1993-06-30

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  WIEMER GABRIELE ,  WAGNER ADALBERT ,  KLEEMANN HEINZ-WERNER

IPC: A61K31/40 ,  A61K31/00 ,  A61K31/41 ,  A61K31/415 ,  A61K31/435 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61K45/00 ,  A61P9/08 ,  A61P9/10 ,  A61P25/28 ,  A61P37/00 ,  C07D207/32 ,  C07D233/84 ,  C07D233/90 ,  C07D255/02 ,  C07D257/04 ,  C07D403/10 ,  C07D471/04 ,  A61K31/33

CPC classification number: A61K31/00 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/495

公开(公告)号：AU627491B2

公开(公告)日：1992-08-27

申请号：AU4095789

申请日：1989-09-01

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH ,  HENNING RAINER ,  RUGER WOLFGANG ,  LERCH ULRICH ,  URBACH HANSJORG ,  HOCK FRANZ ,  WIEMER GABRIELE

IPC: A61K31/495 ,  A61P25/00 ,  A61P25/28 ,  C07D241/08 ,  C07D403/04 ,  C07D405/04 ,  C07D455/04 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D513/04 ,  C07K1/113 ,  C07K5/06

Abstract: The invention relates to compounds of the formula I (I) in which R1, R2 and R4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring alpha -amino acid, R4 can additionally represent R3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R3 and R4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, agents containing these, and the use thereof as pharmaceuticals having a psychotropic action for the prophylaxis of disorders of the central nervous system, especially having a nootropic action for the treatment of cognitive dysfunctions.

公开(公告)号：HU203891B

公开(公告)日：1991-10-28

申请号：HU454289

申请日：1989-09-01

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH ,  HENNING RAINER ,  RUEGER WOLFGANG ,  LERCH ULRICH ,  URBACH HANSJOERG ,  HOCK FRANZ ,  WIEMER GABRIELE

IPC: A61K31/495 ,  A61P25/00 ,  A61P25/28 ,  C07D241/08 ,  C07D403/04 ,  C07D405/04 ,  C07D455/04 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D513/04 ,  C07K1/113 ,  C07K5/06 ,  C07K5/12

Abstract: The invention relates to compounds of the formula I (I) in which R1, R2 and R4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring alpha -amino acid, R4 can additionally represent R3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R3 and R4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, agents containing these, and the use thereof as pharmaceuticals having a psychotropic action for the prophylaxis of disorders of the central nervous system, especially having a nootropic action for the treatment of cognitive dysfunctions.