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公开(公告)号：DK3057959T3
公开(公告)日：2018-06-06
申请号：DK14800181
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , KENNEDY JOSEPH M , LAUFFER DAVID J , LEDEBOER MARK WILLEM , LI PAN , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , XU JINWANG
IPC: C07D403/12 , A61K31/506 , A61P35/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D493/04
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公开(公告)号：AU2014337208B2
公开(公告)日：2018-05-24
申请号：AU2014337208
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , KENNEDY JOSEPH M , LAUFFER DAVID J , LEDEBOER MARK WILLEM , LI PAN , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , XU JINWANG
IPC: C07D403/12 , A61K31/506 , A61P35/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D493/04
Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：NZ700928A
公开(公告)日：2017-06-30
申请号：NZ70092813
申请日：2013-04-23
Applicant: VERTEX PHARMA
Inventor： LAUFFER DAVID J , LI PAN , DENG HONGBO , KENNEDY JOSEPH M , GAO HUAI , CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DUFFY JOHN P , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , LEDEBOER MARK WILLEM , XU JINWANG
IPC: C07D401/14 , A61K31/506 , A61K31/5377 , A61P35/00 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04
Abstract: The present invention relates to compounds of following formula (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders, such as cancer.
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公开(公告)号：HK1208022A1
公开(公告)日：2016-02-19
申请号：HK15108582
申请日：2015-09-02
Applicant: VERTEX PHARMA
Inventor： GAO HUAI , CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , LAUFFER DAVID J , KENNEDY JOSEPH M , LEDEBOER MARK WILLEM , LI PAN , XU JINWANG
IPC: C07D20060101
Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：DK4043460T3
公开(公告)日：2024-08-26
申请号：DK22161962
申请日：2019-04-23
Applicant: MERCK PATENT GMBH , VERTEX PHARMA
Inventor： KULKARNI SHASHANK , YU HENRY , CLARK MICHAEL , BEMIS GUY , BOYD MICHAEL , CHANDUPATLA KISHAN , COLLIER PHILIP , DENG HONGBO , DONG HUIJUN , DORSCH WARREN , HOOVER RUSSELL R , JOHNSON MAC ARTHUR JR , PENNEY MARINA , RONKIN STEVEN , TAKEMOTO DARIN , TANG QING , WAAL NATHAN D , WANG TIANSHENG , LAUFFER DAVID J , LI PAN
IPC: C07D413/14 , A61K31/553 , A61P35/00 , C07D403/04 , C07D409/14 , C07D413/04
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Patent Agency Ranking26.发明专利
公开(公告)号：AU2021246526A1
公开(公告)日：2022-11-03
申请号：AU2021246526
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： GIROUX SIMON , CLARK MICHAEL PHILIP , BRODNEY MICHAEL AARON , NUHANT PHILIPPE MARCEL , ALLEN EMILY ELIZABETH , FIMOGNARI JR , ZAKY MARIAM , BOYD MICHAEL JOHN , DEININGER DAVID D , ZHANG HU , DENG HONGBO , COLLIER PHILIP NOEL , MAXWELL BRAD , WAAL NATHAN D , RONKIN STEVEN M , WANG JIAN , TANG QING , FLEMING GABRIELLE SIMONE , JONES PETER , BOUCHER DIANE MARIE , FANNING LEV T D , HALL AMY B , HURLEY DENNIS JAMES , JOHNSON JR , MAXWELL JOHN PATRICK , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , DAMAGNEZ VERONIQUE , COTTRELL KEVIN MICHAEL , BANDARAGE UPUL KEERTHI
IPC: C07D209/08 , A61K31/35 , A61K31/381 , A61K31/404 , A61P1/00 , A61P1/14 , A61P1/16 , A61P11/00 , A61P11/08 , A61P11/10 , A61P17/00 , A61P31/00 , A61P31/02 , A61P35/00 , C07D209/18 , C07D209/20 , C07D209/30 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D471/04 , C07D493/08
Abstract: Indole derivatives as alpha-l-antitrypsin modulators for treating alpha-l-antitrypsin deficiency (AATD).
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公开(公告)号：AU2021248641A1
公开(公告)日：2022-10-27
申请号：AU2021248641
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： CLARK MICHAEL PHILIP , GIROUX SIMON , COLLIER PHILIP NOEL , TANG QING , WAAL NATHAN D , KESAVAN SARATHY , JONES PETER , BRODNEY MICHAEL AARON , GU WENXIN , BOUCHER DIANE MARIE , FANNING LEV T D , HALL AMY B , HURLEY DENNIS JAMES , JOHNSON JR , MAXWELL JOHN PATRICK , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , DAMAGNEZ VERONIQUE , COTTRELL KEVIN MICHAEL
IPC: C07D491/04 , A61K31/407 , A61P1/00 , A61P1/14 , A61P1/16 , A61P11/00 , A61P11/08 , A61P11/10 , A61P17/00 , A61P31/00 , A61P31/02 , A61P35/00
Abstract: Pyrano[4,3-b]indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD)
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公开(公告)号：PL3784666T3
公开(公告)日：2022-07-18
申请号：PL19726792
申请日：2019-04-23
Applicant: MERCK PATENT GMBH , VERTEX PHARMA
Inventor： YU HENRY , CLARK MICHAEL , BEMIS GUY , BOYD MICHAEL , CHANDUPATLA KISHAN , COLLIER PHILIP , DENG HONGBO , DONG HUIJUN , DORSCH WARREN , HOOVER RUSSELL R , JOHNSON MAC ARTHUR JR , KULKARNI SHASHANK , PENNEY MARINA , RONKIN STEVEN , TAKEMOTO DARIN , TANG QING , WAAL NATHAN D , WANG TIANSHENG , LAUFFER DAVID J , LI PAN
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公开(公告)号：HRP20211855T1
公开(公告)日：2022-03-04
申请号：HRP20211855
申请日：2014-03-12
Applicant: VERTEX PHARMA
Inventor： MAXWELL JOHN PATRICK , CHARIFSON PAUL S , TANG QING , RONKIN STEVEN M , JACKSON KATRINA LEE , PIERCE ALBERT CHARLES , LAUFFER DAVID J , LI PAN , GIROUX SIMON , XU JINWANG , MORRIS MARK A , COURT JOHN J , COTTRELL KEVIN M , DENG HONGBO , WAAL NATHAN D , GU WENXIN
IPC: C07D403/12 , A61K31/517 , A61P35/00 , C07D241/44 , C07D405/12 , C07D413/04 , C07D417/12 , C07D491/052
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公开(公告)号：RS62649B1
公开(公告)日：2021-12-31
申请号：RSP20211467
申请日：2014-03-12
Applicant: VERTEX PHARMA
Inventor： MAXWELL JOHN PATRICK , CHARIFSON PAUL S , TANG QING , RONKIN STEVEN M , JACKSON KATRINA LEE , PIERCE ALBERT CHARLES , LAUFFER DAVID J , LI PAN , GIROUX SIMON , XU JINWANG , MORRIS MARK A , COURT JOHN J , COTTRELL KEVIN M , DENG HONGBO , WAAL NATHAN D , GU WENXIN
IPC: C07D403/12 , A61K31/517 , A61P35/00 , C07D241/44 , C07D405/12 , C07D413/04 , C07D417/12 , C07D491/052
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