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公开(公告)号：AU2021246104A1
公开(公告)日：2022-10-20
申请号：AU2021246104
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： GIROUX SIMON , CLARK MICHAEL PHILIP , TANG QING , NUHANT PHILIPPE MARCEL , JONES PETER , MESSERSMITH DAVID , BANDARAGE UPUL KEERTHI , COTTRELL KEVIN MICHAEL , BRODNEY MICHAEL AARON , FLEMING GABRIELLE SIMONE , WANG JIAN , XU JINWANG , DANIEL KEVIN BRETT , BOYD MICHAEL JOHN , MORRIS MARK A , WAAL NATHAN D , COLLIER PHILIP NOEL , KESAVAN SARATHY , RONKIN STEVEN M , DENG HONGBO , BOUCHER DIANE MARIE , FANNING LEV T D , HALL AMY B , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , MAXWELL JOHN PATRICK , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , DAMAGNEZ VERONIQUE
IPC: C07D209/10 , A61K31/404 , A61P11/00 , A61P29/00 , A61P43/00 , C07D209/12 , C07D209/14 , C07D209/22 , C07D209/24 , C07D209/42 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04
Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).
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Patent Agency Ranking
公开(公告)号：AU2021247285A1
公开(公告)日：2022-10-27
申请号：AU2021247285
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： GIROUX SIMON , NUHANT PHILIPPE MARCEL , BANDARAGE UPUL KEERTHI , GARCIA BARRANTES PEDRO MANUEL , LIAO YUSHENG , GALE-DAY ZACHARY , GU WENXIN , KARNS ALEXANDER S , ZHANG HU , ALLEN EMILY ELIZABETH , XU JINWANG , DENINNO MICHAEL PAUL , TANG QING , BOUCHER DIANE MARIE , FANNING LEV T D , HALL AMY B , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , MAXWELL JOHN PATRICK , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , DAMAGNEZ VERONIQUE , COTTRELL KEVIN MICHAEL
IPC: C07D471/04 , A61K31/4745 , A61P1/00 , A61P1/14 , A61P1/16 , A61P11/00 , A61P11/08 , A61P11/10 , A61P17/00 , A61P31/00 , A61P31/02 , A61P35/00
Abstract: 1H-pyrazolo[4,3-g]isoquinoline and 1H-pyrazolo[4,3-g]quinoline derivatives as alpha-1-antitrypsin modulators for treating alpha-1- antitrypsin deficiency (AATD).
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公开(公告)号：AU2021246527A1
公开(公告)日：2022-10-27
申请号：AU2021246527
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： GIROUX SIMON , CLARK MICHAEL PHILIP , BRODNEY MICHAEL AARON , JONES PETER , DENINNO MICHAEL PAUL , GU WENXIN , TANG QING , STONE STEVEN DAVID , SENTER TIMOTHY J , GALE-DAY ZACHARY , BOUCHER DIANE MARIE , FANNING LEV T D , HALL AMY B , HURLEY DENNIS JAMES , JOHNSON JR , MAXWELL JOHN PATRICK , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , DAMAGNEZ VERONIQUE , COTTRELL KEVIN MICHAEL
IPC: C07D215/20 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4725 , A61P1/00 , A61P1/14 , A61P1/16 , A61P11/00 , A61P11/08 , A61P11/10 , A61P17/00 , A61P31/00 , A61P31/02 , A61P35/00 , C07D215/22 , C07D215/24 , C07D215/38 , C07D217/24 , C07D217/26 , C07D401/04 , C07D401/12 , C07D405/14 , C07D413/12 , C07D413/14
Abstract: 7- or 8-hydroxy-isoquinoline and 7- or 8-hydroxy-quinoline derivatives as alpha-l-antitrypsin modulators for treating alpha-l-antitrypsin deficiency (AATD).
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公开(公告)号：AU2021246526A1
公开(公告)日：2022-11-03
申请号：AU2021246526
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： GIROUX SIMON , CLARK MICHAEL PHILIP , BRODNEY MICHAEL AARON , NUHANT PHILIPPE MARCEL , ALLEN EMILY ELIZABETH , FIMOGNARI JR , ZAKY MARIAM , BOYD MICHAEL JOHN , DEININGER DAVID D , ZHANG HU , DENG HONGBO , COLLIER PHILIP NOEL , MAXWELL BRAD , WAAL NATHAN D , RONKIN STEVEN M , WANG JIAN , TANG QING , FLEMING GABRIELLE SIMONE , JONES PETER , BOUCHER DIANE MARIE , FANNING LEV T D , HALL AMY B , HURLEY DENNIS JAMES , JOHNSON JR , MAXWELL JOHN PATRICK , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , DAMAGNEZ VERONIQUE , COTTRELL KEVIN MICHAEL , BANDARAGE UPUL KEERTHI
IPC: C07D209/08 , A61K31/35 , A61K31/381 , A61K31/404 , A61P1/00 , A61P1/14 , A61P1/16 , A61P11/00 , A61P11/08 , A61P11/10 , A61P17/00 , A61P31/00 , A61P31/02 , A61P35/00 , C07D209/18 , C07D209/20 , C07D209/30 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D471/04 , C07D493/08
Abstract: Indole derivatives as alpha-l-antitrypsin modulators for treating alpha-l-antitrypsin deficiency (AATD).
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公开(公告)号：AU2021248641A1
公开(公告)日：2022-10-27
申请号：AU2021248641
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： CLARK MICHAEL PHILIP , GIROUX SIMON , COLLIER PHILIP NOEL , TANG QING , WAAL NATHAN D , KESAVAN SARATHY , JONES PETER , BRODNEY MICHAEL AARON , GU WENXIN , BOUCHER DIANE MARIE , FANNING LEV T D , HALL AMY B , HURLEY DENNIS JAMES , JOHNSON JR , MAXWELL JOHN PATRICK , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , DAMAGNEZ VERONIQUE , COTTRELL KEVIN MICHAEL
IPC: C07D491/04 , A61K31/407 , A61P1/00 , A61P1/14 , A61P1/16 , A61P11/00 , A61P11/08 , A61P11/10 , A61P17/00 , A61P31/00 , A61P31/02 , A61P35/00
Abstract: Pyrano[4,3-b]indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD)
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公开(公告)号：AU2021247282A1
公开(公告)日：2022-10-27
申请号：AU2021247282
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： GIROUX SIMON , BOYD MICHAEL JOHN , FIMOGNARI JR ROBERT FRANCIS , ZAKY MARIAM , GREY JR RONALD LEE , XU JINWANG , KESAVAN SARATHY , NUHANT PHILIPPE MARCEL , GARCIA BARRANTES PEDRO MANUEL , JONES PETER , BRODNEY MICHAEL AARON , BOUCHER DIANE MARIE , FANNING LEV T D , HALL AMY B , HURLEY DENNIS JAMES , JOHNSON JR , MAXWELL JOHN PATRICK , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , DAMAGNEZ VERONIQUE , COTTRELL KEVIN MICHAEL
IPC: C07D487/04 , A61K31/407 , A61K31/4162 , A61K31/437 , A61P1/00 , A61P1/14 , A61P1/16 , A61P11/00 , A61P11/08 , A61P11/10 , A61P17/00 , A61P31/00 , A61P31/02 , A61P35/00 , C07D471/14
Abstract: Pyrrolo[2,3-f]indazole and 2,4,5,10-tetrazatricyclo[7.3.0.03,7]dodeca-l,3(7),5,8,ll-pentaene derivatives as alpha-l-antitrypsin modulators for treating alpha-l-antitrypsin deficiency (AATD)
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