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1.发明申请C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开用于治疗增殖性疾病的C-MET蛋白激酶抑制剂
公开(公告)号：WO2007111904A3
公开(公告)日：2007-12-13
申请号：PCT/US2007007016
申请日：2007-03-21
Applicant: VERTEX PHARMA , LAUFFER DAVID J , DAVIES ROBERT J , STAMOS DEAN , ARONOV ALEXANDER , DEININGER DAVID D , GREY RONALD JR , XU JINWANG , LI PAN , LEDFORD BRIAN , FARMER LUC , BETHIEL RANDY SCOTT , JACOBS DYLAN , MCGINTY KIRA
Inventor： LAUFFER DAVID J , DAVIES ROBERT J , STAMOS DEAN , ARONOV ALEXANDER , DEININGER DAVID D , GREY RONALD JR , XU JINWANG , LI PAN , LEDFORD BRIAN , FARMER LUC , BETHIEL RANDY SCOTT , JACOBS DYLAN , MCGINTY KIRA
IPC: C07D401/04 , A61K31/4439 , A61K31/497 , A61K35/00 , A61P35/04 , C07D403/04 , C07D417/04 , C07D471/04
CPC classification number: C07D417/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D407/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D451/02 , C07D451/06 , C07D453/02 , C07D471/04 , C07D471/08 , C07D495/04 , C07D498/08 , C07D513/04 , C12N9/99
Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供了制备本发明化合物的方法，包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2007100664A3
公开(公告)日：2008-03-06
申请号：PCT/US2007004737
申请日：2007-02-22
Applicant: VERTEX PHARMA , DAVIES ROBERT J , XU JINWANG
Inventor： DAVIES ROBERT J , XU JINWANG
IPC: A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/55 , A61P1/00 , A61P9/00 , A61P11/06 , A61P25/00 , A61P25/04 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/06 , A61P43/00 , C07D221/20 , C07D471/10
CPC classification number: A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/55 , C07D221/20 , C07D401/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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3.发明申请
公开(公告)号：WO2004046120A3
公开(公告)日：2004-08-12
申请号：PCT/US0336849
申请日：2003-11-17
Applicant: VERTEX PHARMA , PIERCE ALBERT C , ARNOST MICHAEL , DAVIES ROBERT J , FORSTER CORNELIA J , GALULLO VINCENT , GREY RONALD , LEDEBOER MARK , TIAN SHI-KAI , XU JINWANG , BINCH HAYLEY , LEDFORD BRIAN , MESSERSMITH DAVID , NANTHAKUMAR SUGANTHI , JAYARAJ ANDREW
Inventor： PIERCE ALBERT C , ARNOST MICHAEL , DAVIES ROBERT J , FORSTER CORNELIA J , GALULLO VINCENT , GREY RONALD , LEDEBOER MARK , TIAN SHI-KAI , XU JINWANG , BINCH HAYLEY , LEDFORD BRIAN , MESSERSMITH DAVID , NANTHAKUMAR SUGANTHI , JAYARAJ ANDREW
IPC: A61K31/4196 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D249/10 , C07D249/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/02 , C07D417/02 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07D495/04 , A61K31/41 , C07D498/04 , C07D513/04
CPC classification number: C07D401/04 , C07D249/10 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07D495/04
Abstract: The present invention relates to inhibitors of protein kinases of formula I. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及式I的蛋白激酶抑制剂。本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2013163190A8
公开(公告)日：2014-11-27
申请号：PCT/US2013037811
申请日：2013-04-23
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , KENNEDY JOSEPH M , LAUFFER DAVID J , LEDEBOER MARK WILLEM , LI PAN , XU JINWANG
IPC: C07D401/14 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048
CPC classification number: A61K31/506 , A61K9/20 , A61K9/48 , A61K31/5377 , A61K41/0038 , A61K47/481 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
Abstract: The present invention relates to compounds of following formula (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders, such as cancer.
Abstract translation: 本发明涉及可用作DNA-PK抑制剂的下式（I）化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症例如癌症的方法。
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公开(公告)号：WO2008005295A3
公开(公告)日：2008-06-05
申请号：PCT/US2007015050
申请日：2007-06-28
Applicant: VERTEX PHARMA , BANDARAGE UPUL K , XU JINWANG , DAVIES ROBERT J , CHARIFSON PAUL S , ARIMOTO RIEKO
Inventor： BANDARAGE UPUL K , XU JINWANG , DAVIES ROBERT J , CHARIFSON PAUL S , ARIMOTO RIEKO
IPC: A61K31/438 , A61K31/4545 , A61K31/46 , A61K31/5355 , A61P25/00 , A61P25/04 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/06 , A61P43/00 , C07D221/20 , C07D471/10
CPC classification number: A61K31/4545 , A61K31/438 , A61K31/46 , A61K31/5355 , C07D221/20 , C07D401/04 , C07D405/06 , C07D409/06 , C07D451/04
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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Patent Agency Ranking
公开(公告)号：AU2021247285A1
公开(公告)日：2022-10-27
申请号：AU2021247285
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： GIROUX SIMON , NUHANT PHILIPPE MARCEL , BANDARAGE UPUL KEERTHI , GARCIA BARRANTES PEDRO MANUEL , LIAO YUSHENG , GALE-DAY ZACHARY , GU WENXIN , KARNS ALEXANDER S , ZHANG HU , ALLEN EMILY ELIZABETH , XU JINWANG , DENINNO MICHAEL PAUL , TANG QING , BOUCHER DIANE MARIE , FANNING LEV T D , HALL AMY B , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , MAXWELL JOHN PATRICK , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , DAMAGNEZ VERONIQUE , COTTRELL KEVIN MICHAEL
IPC: C07D471/04 , A61K31/4745 , A61P1/00 , A61P1/14 , A61P1/16 , A61P11/00 , A61P11/08 , A61P11/10 , A61P17/00 , A61P31/00 , A61P31/02 , A61P35/00
Abstract: 1H-pyrazolo[4,3-g]isoquinoline and 1H-pyrazolo[4,3-g]quinoline derivatives as alpha-1-antitrypsin modulators for treating alpha-1- antitrypsin deficiency (AATD).
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公开(公告)号：AU2020286424A1
公开(公告)日：2022-01-06
申请号：AU2020286424
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE , BOYD MICHAEL JOHN , BRODNEY MICHAEL AARON , CLARK MICHAEL PHILIP , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GAGNON KEVIN JAMES , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , GREY JR RONALD LEE , GUIDO SAMANTHA , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , LAI MEI-HSIU , LIU SIYING , LOOKER ADAM , MAXWELL BRAD , MAXWELL JOHN PATRICK , MEDEK ALES , NUHANT PHILIPPE MARCEL , OVERHOFF KIRK ALAN , RODAY SETU , ROEPER STEFANIE , RONKIN STEVEN M , SAWANT RUPA , SHI YI , SHRESTHA MUNA , SPOSATO MARISA , STAVROPOULOS KATHY , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN , XU JINWANG , ZAKY MARIAM , COTTRELL KEVIN MICHAEL
IPC: C07D231/56 , A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.
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公开(公告)号：PL3459942T3
公开(公告)日：2021-10-11
申请号：PL18186230
申请日：2013-04-23
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , KENNEDY JOSEPH M , LAUFFER DAVID J , LEDEBOER MARK WILLEM , LI PAN , XU JINWANG
IPC: C07D401/14 , A61K31/506 , A61K41/00 , A61P35/00 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04
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公开(公告)号：CA2871471C
公开(公告)日：2021-06-01
申请号：CA2871471
申请日：2013-04-23
Applicant: VERTEX PHARMA
Inventor： GAO HUAI , CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , LAUFFER DAVID J , KENNEDY JOSEPH M , LEDEBOER MARK WILLEM , LI PAN , XU JINWANG
IPC: C07D401/14 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048
Abstract: The present invention relates to compounds of following formula (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders, such as cancer.
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公开(公告)号：CO2021005884A2
公开(公告)日：2021-05-20
申请号：CO2021005884
申请日：2021-05-05
Applicant: VERTEX PHARMA
Inventor： BLIGH CAVAN MCKEON , BRODNEY MICHAEL AARON , ECCLES MARY ELIZABETH , GAGNON KEVIN JAMES , HOOD SARAH CAROL , HUSSEY JOSHUA KENNEDY , LOOKER ADAM , MAXWELL JOHN PATRICK , MEDEK ALES , NAVAMAL METTACHIT , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , TANG QING , WALDO MICHAEL , BANDARAGE UPUL KEERTHI , BOUCHER DIANE M , BOYD MICHAEL JOHN , DAMAGNEZ VERONIQUE , DEWEY FANNING LEV TYLER , FIMOGNARI JR ROBERT FRANCIS , GARCIA BARRANTES PEDRO M , GIROUX SIMON , GREY JR RONALD LEE , HALL AMY BETH , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , NUHANT PHILIPPE MARCEL , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , XU JINWANG , MAXWELL BRAD D , COTTRELL KEVIN MICHAEL
IPC: A61P1/16 , A61K31/4162 , A61K31/4178 , A61K31/4196 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61P11/00 , C07D471/14 , C07D487/04 , C07D487/14 , C07D519/00
Abstract: Nuevos compuestos, composiciones y métodos para usar y preparar los mismos, los cuales pueden ser útiles para tratar la deficiencia de alfa-1 antitripsina (AATD).
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