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公开(公告)号：WO2013163190A8
公开(公告)日：2014-11-27
申请号：PCT/US2013037811
申请日：2013-04-23
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , KENNEDY JOSEPH M , LAUFFER DAVID J , LEDEBOER MARK WILLEM , LI PAN , XU JINWANG
IPC: C07D401/14 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048
CPC classification number: A61K31/506 , A61K9/20 , A61K9/48 , A61K31/5377 , A61K41/0038 , A61K47/481 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
Abstract: The present invention relates to compounds of following formula (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders, such as cancer.
Abstract translation: 本发明涉及可用作DNA-PK抑制剂的下式（I）化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症例如癌症的方法。
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公开(公告)号：AU2021247285A1
公开(公告)日：2022-10-27
申请号：AU2021247285
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： GIROUX SIMON , NUHANT PHILIPPE MARCEL , BANDARAGE UPUL KEERTHI , GARCIA BARRANTES PEDRO MANUEL , LIAO YUSHENG , GALE-DAY ZACHARY , GU WENXIN , KARNS ALEXANDER S , ZHANG HU , ALLEN EMILY ELIZABETH , XU JINWANG , DENINNO MICHAEL PAUL , TANG QING , BOUCHER DIANE MARIE , FANNING LEV T D , HALL AMY B , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , MAXWELL JOHN PATRICK , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , DAMAGNEZ VERONIQUE , COTTRELL KEVIN MICHAEL
IPC: C07D471/04 , A61K31/4745 , A61P1/00 , A61P1/14 , A61P1/16 , A61P11/00 , A61P11/08 , A61P11/10 , A61P17/00 , A61P31/00 , A61P31/02 , A61P35/00
Abstract: 1H-pyrazolo[4,3-g]isoquinoline and 1H-pyrazolo[4,3-g]quinoline derivatives as alpha-1-antitrypsin modulators for treating alpha-1- antitrypsin deficiency (AATD).
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公开(公告)号：AU2021246527A1
公开(公告)日：2022-10-27
申请号：AU2021246527
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： GIROUX SIMON , CLARK MICHAEL PHILIP , BRODNEY MICHAEL AARON , JONES PETER , DENINNO MICHAEL PAUL , GU WENXIN , TANG QING , STONE STEVEN DAVID , SENTER TIMOTHY J , GALE-DAY ZACHARY , BOUCHER DIANE MARIE , FANNING LEV T D , HALL AMY B , HURLEY DENNIS JAMES , JOHNSON JR , MAXWELL JOHN PATRICK , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , DAMAGNEZ VERONIQUE , COTTRELL KEVIN MICHAEL
IPC: C07D215/20 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4725 , A61P1/00 , A61P1/14 , A61P1/16 , A61P11/00 , A61P11/08 , A61P11/10 , A61P17/00 , A61P31/00 , A61P31/02 , A61P35/00 , C07D215/22 , C07D215/24 , C07D215/38 , C07D217/24 , C07D217/26 , C07D401/04 , C07D401/12 , C07D405/14 , C07D413/12 , C07D413/14
Abstract: 7- or 8-hydroxy-isoquinoline and 7- or 8-hydroxy-quinoline derivatives as alpha-l-antitrypsin modulators for treating alpha-l-antitrypsin deficiency (AATD).
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公开(公告)号：AU2020286424A1
公开(公告)日：2022-01-06
申请号：AU2020286424
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE , BOYD MICHAEL JOHN , BRODNEY MICHAEL AARON , CLARK MICHAEL PHILIP , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GAGNON KEVIN JAMES , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , GREY JR RONALD LEE , GUIDO SAMANTHA , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , LAI MEI-HSIU , LIU SIYING , LOOKER ADAM , MAXWELL BRAD , MAXWELL JOHN PATRICK , MEDEK ALES , NUHANT PHILIPPE MARCEL , OVERHOFF KIRK ALAN , RODAY SETU , ROEPER STEFANIE , RONKIN STEVEN M , SAWANT RUPA , SHI YI , SHRESTHA MUNA , SPOSATO MARISA , STAVROPOULOS KATHY , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN , XU JINWANG , ZAKY MARIAM , COTTRELL KEVIN MICHAEL
IPC: C07D231/56 , A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.
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公开(公告)号：PL3459942T3
公开(公告)日：2021-10-11
申请号：PL18186230
申请日：2013-04-23
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , KENNEDY JOSEPH M , LAUFFER DAVID J , LEDEBOER MARK WILLEM , LI PAN , XU JINWANG
IPC: C07D401/14 , A61K31/506 , A61K41/00 , A61P35/00 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04
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Patent Agency Ranking
公开(公告)号：CA2871471C
公开(公告)日：2021-06-01
申请号：CA2871471
申请日：2013-04-23
Applicant: VERTEX PHARMA
Inventor： GAO HUAI , CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , LAUFFER DAVID J , KENNEDY JOSEPH M , LEDEBOER MARK WILLEM , LI PAN , XU JINWANG
IPC: C07D401/14 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048
Abstract: The present invention relates to compounds of following formula (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders, such as cancer.
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公开(公告)号：CO2021005884A2
公开(公告)日：2021-05-20
申请号：CO2021005884
申请日：2021-05-05
Applicant: VERTEX PHARMA
Inventor： BLIGH CAVAN MCKEON , BRODNEY MICHAEL AARON , ECCLES MARY ELIZABETH , GAGNON KEVIN JAMES , HOOD SARAH CAROL , HUSSEY JOSHUA KENNEDY , LOOKER ADAM , MAXWELL JOHN PATRICK , MEDEK ALES , NAVAMAL METTACHIT , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , TANG QING , WALDO MICHAEL , BANDARAGE UPUL KEERTHI , BOUCHER DIANE M , BOYD MICHAEL JOHN , DAMAGNEZ VERONIQUE , DEWEY FANNING LEV TYLER , FIMOGNARI JR ROBERT FRANCIS , GARCIA BARRANTES PEDRO M , GIROUX SIMON , GREY JR RONALD LEE , HALL AMY BETH , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , NUHANT PHILIPPE MARCEL , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , XU JINWANG , MAXWELL BRAD D , COTTRELL KEVIN MICHAEL
IPC: A61P1/16 , A61K31/4162 , A61K31/4178 , A61K31/4196 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61P11/00 , C07D471/14 , C07D487/04 , C07D487/14 , C07D519/00
Abstract: Nuevos compuestos, composiciones y métodos para usar y preparar los mismos, los cuales pueden ser útiles para tratar la deficiencia de alfa-1 antitripsina (AATD).
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公开(公告)号：DK3459942T3
公开(公告)日：2021-03-08
申请号：DK18186230
申请日：2013-04-23
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , KENNEDY JOSEPH M , LAUFFER DAVID J , LEDEBOER MARK WILLEM , LI PAN , XU JINWANG
IPC: C07D401/14 , A61K31/506 , A61K41/00 , A61P35/00 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04
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公开(公告)号：UA115983C2
公开(公告)日：2018-01-25
申请号：UAA201412561
申请日：2013-04-23
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , KENNEDY JOSEPH M , LAUFFER DAVID J , LEDEBOER MARK WILLEM , LI PAN , XU JINWANG
IPC: C07D401/14 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048
Abstract: Винахід, щопропонується, стосуєтьсясполук, яківідповідаютьнаступнійформулі EMBED ISISServer , (I) якізастосовуютьсяякінгібіториДНК-ПК. Такожу винаходіпропонуютьсяфармацевтичноприйнятнікомпозиції, щомістятьвказанісполуки, іспособиз використаннямкомпозиційу лікуваннірізнихзахворювань, станівабопорушень, такихякрак.
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公开(公告)号：CA2927392C
公开(公告)日：2021-11-09
申请号：CA2927392
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , KENNEDY JOSEPH M , LAUFFER DAVID J , LEDEBOER MARK WILLEM , LI PAN , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , XU JINWANG
IPC: C07D403/12 , A61K31/506 , A61P35/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D493/04
Abstract: 81796253 ABSTRACT The present invention relates to compounds useful as inhibitors of DNA-PK such as 0 F3C N-CH3 11JH H,N (S. z N CH3 N I N H3 . The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. Date Recue/Date Received 2021-02-25
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