Abstract:
PURPOSE:To simply measure the degree of crystallization of a drug preparation of every kind, especially, a beta-lactam compound with high accuracy by measuring the intensity of extremely weak chemiluminescence of the drug preparation. CONSTITUTION:It is said that there is predetermined relation between the value of extremely weak chemiluminescence CL of a predetermined compound, especially, a beta-lactam compound and the degree of crystallization thereof when temp. is constant. Then, in order to measure the degree of crystallization of a drug preparation, especially, the beta-lactam compound, a first, the CL value of a compound whose degree of crystallization is known is measured, for example, by a chemiluminescence measuring apparatus amplifying the receiving quantity of the light from a compound within a predetermined time to be capable of measuring, displaying and recording the same as a photoelectron pulse to prepare a calibration curve wherein a degree of crystallization is set to a horizontal axis and luminous intensity is set to a vertical axis. When the luminous intensity of a compound whose degree of crystallization is unknown is measured, the degree of crystallization thereof can be easily calculated and the stability thereof can be evaluated.
Abstract:
The present invention relates to storage stable multi-component mixtures containing:A. at least one compound selected from the group consisting of lactams and aza lactams;B. at least one compound selected from the group consisting of water, and difunctional acid-group-free organic compounds containing functional groups selected from the group consisting of hydroxyl, primary amino-, secondary amino, and sulfhydryl groups; andC. at least one acid selected from the group consisting ofI. mono- and poly-carboxylic acids,Ii. organic and inorganic acids of phosphorus,Iii. inorganic acids of boron, andIv. partially hydrolyzed antimonous and antimonic acid esters of polyhydroxyl compounds with molecular weights of from 62 to 600.
Abstract:
Hexaorgano distannanes of the general formula R.sub.3 Sn-SnR.sub.3 significantly reduce or eliminate the discoloration which occurs when mixtures containing an alkali metal salt of a lactam are stored under an inert atmosphere for extended periods of time at temperatures between ambient and 100.degree.C. R in the foregoing formula represents a monovalent hydrocarbon radical containing between 1 and 20 carbon atoms.
Abstract:
Monomer composition comprises (a) liquid N-vinyl-epsilon -caprolactam and (b) at least a N-oxyl-compound of secondary amine, which carries no hydrogen atoms at the alpha -carbon atom. An independent claim is included for use of the monomer composition for polymerization reactions, where the monomer composition is fluidly stored at above 40[deg] C and fed to the polymerization reactor when required.