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公开(公告)号：KR1020110061432A
公开(公告)日：2011-06-09
申请号：KR1020090118079
申请日：2009-12-01
Applicant: 한국과학기술연구원
CPC classification number: A61K49/0017 , A61K49/0021 , A61K49/0054 , A61K49/1824 , G01N33/49 , G01N33/58
Abstract: PURPOSE: Aqueous-dispersed chemical-luminescent nanoparticles, a producing method thereof, and a use thereof are provided to accurately and extensively diagnose active oxygen related disease by directly imaging hydrogen peroxide. CONSTITUTION: Aqueous-dispersed chemical-luminescent nanoparticles contain the following: 0.01~3wt% of core containing a hydrophobic chemical-luminescent substance; 0.5~30wt% of surfactant surrounding the core; and 67~99.49wt% water. The luminescent wavelength of the hydrophobic chemical-luminescent substance is 650~900nm. The hydrophobic chemical-luminescent substance is formed with a peroxyoxalate derivative and a fluorescent material. The surfactant is poloxamer.
Abstract translation: 目的：通过直接成像过氧化氢，提供水分散化学发光纳米颗粒及其制备方法及其用途，以准确和广泛地诊断活性氧相关疾病。 构成：含水分散化学发光纳米粒子含有以下物质：含有疏水性化学发光物质的核心的0.01〜3重量％ 核心表面活性剂占0.5〜30wt％; 和67〜99.49重量％的水。 疏水化学发光物质的发光波长为650〜900nm。 疏水性化学发光物质由过氧草酸酯衍生物和荧光物质形成。 表面活性剂是泊洛沙姆。
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公开(公告)号：KR1020110043344A
公开(公告)日：2011-04-27
申请号：KR1020090100417
申请日：2009-10-21
Applicant: 한국과학기술연구원
Abstract: PURPOSE: Porous micro/nanoparticles are provided to generate carbon dioxide gas in hydrolysis and to enable use as a contrast agent by holding carbon dioxide even if gas is not added in contrast. CONSTITUTION: Porous micro/nanoparticles are represented by chemical formula 1. In chemical formula 1, a, b, c, and d are 0-1; a+b+c+d = 1; n is an integer of 1-1000; A is a repeating unit represented by chemical formula 2; B is a repeating unit represented by chemical formula 3; C is a repeating unit represented by chemical formula 4; and D is a repeating unit represented by chemical formula 5. In chemical formulae 2-5, R and R' are C1-10 alkyl group or cholesteryl group; e, f, h, i, j, m, o, p, r, s, t, w and x are 0 or 1; g, k, l, q, u, v, y and z are an integer of 1-10; and X is -CH(CH3)- or -CH2-.
Abstract translation: 目的：提供多孔微/纳米颗粒水解产生二氧化碳气体，即使不添加气体，也可通过保持二氧化碳作为造影剂。 构成：多孔微纳米颗粒由化学式1表示。在化学式1中，a，b，c和d为0-1; a + b + c + d = 1; n为1-1000的整数; A是由化学式2表示的重复单元; B是由化学式3表示的重复单元; C是由化学式4表示的重复单元; D是由化学式5表示的重复单元。在化学式2-5中，R和R'为C 1-10烷基或胆固醇基; e，f，h，i，j，m，o，p，r，s，t，w和x分别为0或1; g，k，l，q，u，v，y和z为1-10的整数; 并且X是-CH（CH 3） - 或-CH 2 - 。
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公开(公告)号：KR1020100037494A
公开(公告)日：2010-04-09
申请号：KR1020080096838
申请日：2008-10-01
Applicant: 한국과학기술연구원
IPC: A61K49/04 , A61K31/728 , A61P35/00 , B82Y5/00
CPC classification number: A61K49/0054 , A61K9/5161 , A61K49/0021 , B82Y5/00
Abstract: PURPOSE: A contrast medium for cancer diagnosis containing amphiphilic hyaluronic acid complex nanoparticle is provided to form nano self-aggregates and easily accumulate in cancer tisse. CONSTITUTION: A contrast medium for cancer diagnosis containing amphiphilic hyaluronic acid complex nanoparticle is prepared by binding near infrared ray fluorescence to amphiphilic hyaluronic acid. The near infrared ray fluorescence is cyanine, fluorescein, tetramethylrhodamine, BODIPY, or Alexa. The contrast medium for cancer diagnosis further contains radioactive isotope, quantum dot, or MRI contrast medium.
Abstract translation: 目的：提供含有两亲性透明质酸复合纳米颗粒的癌症诊断造影剂，形成纳米自聚集体，容易积聚在癌症之中。 构成：通过将近红外线荧光结合到两亲性透明质酸来制备含有两亲性透明质酸复合纳米颗粒的癌症诊断用造影剂。 近红外线荧光是花青，荧光素，四甲基罗丹明，BODIPY或Alexa。 用于癌症诊断的造影剂还包含放射性同位素，量子点或MRI造影剂。
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公开(公告)号：KR1020050008323A
公开(公告)日：2005-01-21
申请号：KR1020030048240
申请日：2003-07-15
Applicant: 한국과학기술연구원 , 주식회사 스마트세이프존
IPC: C08B37/08
Abstract: PURPOSE: Provided is a chitosan composite containing a hydrophobic group, which can encapsulate various hydrophobic pharmaceuticals and therapeutic proteins to give excellent biocompatibility and biodegradability, and thus is useful for pharmaceutical carrier. CONSTITUTION: The chitosan composite containing a hydrophobic group forms a nanosized self-aggregate in aqueous solution. Particularly, an amino group of chitosan is coupled with a carboxyl group of hydrophobic bile acid to form a nanosized self-aggregate. The chitosan is selected from the group consisting of water soluble glycol chitosan, chitosan oligomer and 50%-acetylated chitosan. The hydrophobic bile acid is selected from the group consisting of cholic acid, chenodeoxycholic acid, deoxycholic acid, lithocholic acid, 7-oxo-lithocholic acid and 5-beta-cholanic acid.
Abstract translation: 目的：提供一种含有疏水基团的壳聚糖复合物，其可以包封各种疏水性药物和治疗性蛋白质，以提供优异的生物相容性和生物降解性，因此可用于药物载体。 构成：含有疏水基团的壳聚糖复合物在水溶液中形成纳米尺寸的自聚集体。 特别地，壳聚糖的氨基与疏水性胆汁酸的羧基结合形成纳米化的自聚集体。 壳聚糖选自水溶性乙二醇壳聚糖，壳聚糖低聚物和50％乙酰化壳聚糖。 疏水性胆汁酸选自胆酸，鹅脱氧胆酸，脱氧胆酸，石胆酸，7-氧代 - 石胆酸和5-β-胆碱酸。
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Patent Agency Ranking
公开(公告)号：KR100428418B1
公开(公告)日：2004-04-28
申请号：KR1020020011040
申请日：2002-02-28
Applicant: 한국과학기술연구원
IPC: A61K9/107
Abstract: PURPOSE: A process of preparing a fat emulsion using oils having higher specific gravity than water as a fat emulsion base material and amphoteric surfactants as an emulsifier is provided. The fat emulsion exhibits excellent expression efficiency in adhesive cell lines as well as in the presence of serum as compared to conventional liposome or squalane-based fat emulsion formulation and thus permits easy in-vitro assay of gene expression efficiency. CONSTITUTION: A fat emulsion comprises: 2 to 30% by weight of oil mixtures comprising iodized oil and one or more glyceride-based oils such as squalene or squalane as a fat emulsion base; 0.01 to 40% by weight of one or more amphoteric surfactants; 0.01 to 10% by weight of hydrophilic polymers, phospholipid combined with hydrophilic polymers or polymerizable phospholipid; 0.01 to 10% by weight of glycerol, soluble peptide or soluble protein; and the balance comprising water. The oil mixtures contain 40% by weight of iodized oil selected from the group consisting of iodized poppy seed oil.
Abstract translation: 目的：提供一种使用比重比水高的油作为脂肪乳剂基础材料和两性表面活性剂作为乳化剂制备脂肪乳剂的方法。 与常规脂质体或角鲨烷基脂肪乳剂制剂相比，脂质乳剂在粘附细胞系以及血清存在下表现出优异的表达效率，因此允许基因表达效率的体外容易测定。 组成：脂肪乳剂包含：2-30重量％的包含碘化油和一种或多种甘油酯基油例如角鲨烯或角鲨烷作为脂肪乳剂基质的油混合物; 0.01至40重量％的一种或多种两性表面活性剂; 0.01至10重量％的亲水性聚合物，与亲水性聚合物或可聚合磷脂结合的磷脂; 0.01至10重量％的甘油，可溶性肽或可溶性蛋白质; 余量包含水。 油混合物含有40重量％的选自碘化罂粟籽油的碘化油。
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公开(公告)号：KR100342835B1
公开(公告)日：2002-07-02
申请号：KR1019990031339
申请日：1999-07-30
Applicant: 한국과학기술연구원
IPC: A61K9/107
Abstract: 본발명은세포내로유전자 DNA 및생물학적활성약물을전달할수 있는비트리글리세라이드계열지방유제와트리글리세라이드또는에틸스테아레이트계지질미립구및 그들의제조방법에관한것이다. 또한본 발명은비트리글리세라이드계열지방유제와트리글리세라이드계열또는에틸스테아레이트지질미립구를사용하여세포내로 DNA 와같은생물학적활성약물을효과적으로전달하는방법에관한것이다. 또한본 발명은지용성및 소수성약물을함유한스쿠알렌또는스쿠알란을기재로한 지방유제와에틸스테아레이트를기재로한 지질미립구및 그들의제조방법에관한것이다.
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公开(公告)号：KR100334435B1
公开(公告)日：2002-05-03
申请号：KR1019997005944
申请日：1997-12-31
Applicant: 한국과학기술연구원
IPC: A61K9/19
CPC classification number: A61K9/7007 , Y10S514/953 , Y10S514/964 , Y10S514/975
Abstract: 본발명은다공성매트릭스형약물전달제제를제조하는방법을제공한다. 상기방법은약물이포함된수용액을고분자화합물과계면활성제가유기용매에용해된유기용액에분산, 교반시켜에멀젼으로만든다음, 원하는매트릭스형태로만들어즉시동결건조하거나상온에서일정시간즉 매트릭스표면이경화되기시작할때까지건조시킨후 다시진공건조하여다공성매트릭스를제조하는것으로이루어진다.
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公开(公告)号：KR1020010100194A
公开(公告)日：2001-11-14
申请号：KR1020000012465
申请日：2000-03-13
Applicant: 한국과학기술연구원
IPC: A61K47/44
CPC classification number: A61K9/1075 , A61K9/19
Abstract: 본 발명은 여러 가지 물질의 가용화를 위한 새로운 조성물; 상기 조성물의 액상 제형 및 분말 제형; 및 상기 조성물과 제형의 제조 방법에 관한 것으로, 보다 상세하게는 상기 조성물은 1종 이상의 모노글리세라이드 (monoglyceride)계 화합물 9∼90 중량, 1종 이상의 유화제 0.01∼90 중량, 1종 이상의 난용성 물질 0∼50 중량및 유기 용매 0∼90.9 중량로 이루어지며, 본 발명에 의한 제형은 손으로 흔들어 주는 등의 최소한의 기계적 도움에 의해 입자가 쉽게 분산되어 작고 균질한 입자를 형성하므로 부가적인 처리 과정에 따른 산화 및 변성의 문제가 일어나지 않으며 보관시 상분리가 일어나지 않아 약물 전달 시스템에 유용하게 이용할 수 있다.
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公开(公告)号：KR1020000000265A
公开(公告)日：2000-01-15
申请号：KR1019990043354
申请日：1999-10-08
Applicant: 한국과학기술연구원
IPC: A61K9/16
CPC classification number: A61K9/167 , Y02A50/471
Abstract: PURPOSE: A microsphere is provided to enhance the absorption efficiency in the small intestines on oral medication by modifying its surface using the Cholera Toxin B(CTB). CONSTITUTION: A microsphere is formed by: combining the CTB(Cholera Toxin B) to a microsphere containing more than one kinds of physiological activating substances in its inside or on its surface through a polyethylene glycol linker(PEG) having 3000-4000 of molecular weight.
Abstract translation: 目的：通过使用霍乱毒素B（CTB）改变其表面，提供微球以增强口服药物中小肠的吸收效率。 构成：通过以下方法形成微球：通过具有3000-4000分子量的聚乙二醇接头（PEG）将CTB（霍乱毒素B）与其内部或其表面上含有多于一种生理活化物质的微球结合 。
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