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公开(公告)号：KR100450307B1
公开(公告)日：2004-09-30
申请号：KR1020010045860
申请日：2001-07-30
Applicant: 한국과학기술연구원
IPC: C07K14/47
CPC classification number: C12N9/0036 , C07K14/47 , C07K2319/00
Abstract: The present invention relates to a C-terminal region protein of human nucleolar phosphoprotein hNopp140 and the gene thereof. Particularly, the present invention relates to a C-terminal region protein of the human nucleolar phosphoprotein hNopp140, which binds specifically to doxorubicin, and the gene encoding the same. C-terminal region protein of the human nucleolar phosphoprotein hNopp140 of the present invention can be effectively used to reduce side effects of the anticancer agent and improve its activity.
Abstract translation: 本发明涉及人核仁磷蛋白hNopp140的C末端区域蛋白及其基因。 特别地，本发明涉及与多柔比星特异性结合的人核仁磷蛋白hNopp140的C末端区域蛋白和编码它的基因。 本发明的人核仁磷蛋白hNopp140的C末端区域蛋白质可以有效地用于减少抗癌剂的副作用并改善其活性。
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公开(公告)号：KR100445437B1
公开(公告)日：2004-08-21
申请号：KR1020020007495
申请日：2002-02-08
Applicant: 한국과학기술연구원
IPC: C07H15/22
CPC classification number: C07H15/232
Abstract: The present invention relates to novel oxazolidinone derivatives represented as following compound I and a process for the preparation thereof. The compounds of the present invention have wide antibacterial spectrums superior antibacterial activity and low toxicity. Therefore, it can be expected to use as novel antibacterial agent. wherein, R 1 is alkylcarboxyl group or -CH 2 R 2 (wherein, R 2 is OH, argido group, -OR 3 (wherein, R 3 is C 1-4 alkyl, methansulfonyl, p-toluensulfonyl, carboxyl, C 1-4 alkylcarboxyl, C 1-4 alkylcarbonyl, benzyloxycarbonyl, or imidazolylcarbonyl), or -NHR 4 ).
Abstract translation: 本发明涉及下述化合物I所代表的新型恶唑烷酮衍生物及其制备方法。 本发明的化合物具有优异的抗菌活性和低毒性的广谱抗菌谱。 因此，可以期待用作新型抗菌剂。 其中R SUB 1 1是烷基羧基或-CH 2 SUB 2 R SUB 2 SUB（其中，R SUB 2 2 SUB是 OH，Argido基团，-OR SUB 3（其中，R SUB 3是SUB 1-4烷基，甲磺酰基，对甲苯磺酰基， 羧基，C 1-4亚烷基羧基，C 1-4亚烷基羰基，苄氧基羰基或咪唑基羰基）或-NHR SUB 4 / SUB）。
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公开(公告)号：KR100428469B1
公开(公告)日：2004-04-27
申请号：KR1020010020421
申请日：2001-04-17
Applicant: 한국과학기술연구원
IPC: C07K7/08
CPC classification number: C07K7/08
Abstract: The present invention relates to carbohydrate-specific peptides, which have a strong affinity and preparation method thereof. Particularly, the present invention relates to carbohydrate-specific peptides, which have been developed to have an increased strong affinity to carbohydrates by the multiple combinations of peptides having carbohydrates-specific amino acid sequences and preparation method thereof. Carbohydrate-specific peptides of the present invention have a very strong affinity under micromol, so that they can shut off recognition between cells transferred by specific carbohydrates, which means they can be used for the treatment of diseases mediated by recognition between cells and used as a diagnostic kit which diagnoses diseases by confirming the existence of any specific carbohydrate.
Abstract translation: 本发明涉及具有强亲和力的碳水化合物特异性肽及其制备方法。 特别地，本发明涉及通过具有碳水化合物特异性氨基酸序列的肽的多种组合具有增强的对碳水化合物的强亲和力的碳水化合物特异性肽及其制备方法。 本发明的碳水化合物特异性肽在微摩尔下具有非常强的亲和力，从而它们可以关闭由特定碳水化合物转移的细胞之间的识别，这意味着它们可以用于治疗由细胞间识别介导的疾病并用作 通过确认任何特定碳水化合物的存在来诊断疾病的诊断试剂盒。
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公开(公告)号：KR100426612B1
公开(公告)日：2004-04-08
申请号：KR1019990021582
申请日：1999-06-10
Applicant: 한국과학기술연구원
IPC: C12Q1/00
Abstract: PURPOSE: A method for quantifying sugar attached to a solid surface is provided to precisely quantifying the sugar through a gentle reaction by using an enzyme for separating the sugar from a reporter substance without any preprocessing procedure. CONSTITUTION: A method for quantifying sugar attached to a solid surface includes the steps of attaching sugar coupled with reporter molecules such as p-nitrophenyle on a surface of a solid such as a hydrogel selected from Cephalos or Agarose, dissolving glycoside coupling between the sugar and the reporter molecules with an enzyme such as glucosidase, amyloglucosidase, cellulase, fucosidase, mannosidase and galactosidase, and quantifying the dissolved reporter molecules
Abstract translation: 目的：提供一种量化附着于固体表面的糖的方法，以通过使用用于从报道物质分离糖的酶进行温和反应来精确定量糖，而无需任何预处理程序。 构成：定量附着于固体表面的糖的方法包括以下步骤：将糖与报道分子（例如对硝基苯基）偶联在固体（例如选自头孢菌素或琼脂糖的水凝胶）的表面上，将糖与糖之间的糖苷偶联 报道分子与酶如葡糖苷酶，淀粉葡糖苷酶，纤维素酶，岩藻糖苷酶，甘露糖苷酶和半乳糖苷酶，并定量溶解的报道分子
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公开(公告)号：KR1020030067355A
公开(公告)日：2003-08-14
申请号：KR1020020007495
申请日：2002-02-08
Applicant: 한국과학기술연구원
IPC: C07H15/22
CPC classification number: C07H15/232
Abstract: PURPOSE: Provided is a heterodimeric conjugate of neomycin-oxazolidinone which is useful as an antiviral agent and an antibacterial agent. Also, provided are the preparation method and use thereof. CONSTITUTION: A heterodimeric conjugate of neomycin-oxazolidinone is represented by the formula(1), wherein n is an integer of 2-10 and Ac represents an acetyl group. It is characterized by specifically bonding to 16S rRNA, RRE, RNA or 23S rRNA.
Abstract translation: 目的：提供新霉素 - 恶唑烷酮的异二聚体缀合物，其可用作抗病毒剂和抗菌剂。 此外，提供其制备方法和用途。 构成：新霉素 - 恶唑烷酮的异二聚体缀合物由式（1）表示，其中n为2-10的整数，Ac为乙酰基。 其特征是特异性结合16S rRNA，RRE，RNA或23S rRNA。
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Patent Agency Ranking
公开(公告)号：KR1020020091627A
公开(公告)日：2002-12-06
申请号：KR1020010030455
申请日：2001-05-31
Applicant: 한국과학기술연구원
IPC: C12Q1/68
Abstract: PURPOSE: Provided is a method of selecting new target mRNA from mRNA libraries by using affinity selection to identify new mRNA easily and rapidly by using human genome gene. CONSTITUTION: The method of selecting new target mRNA from mRNA libraries by using affinity selection comprises the steps of: selecting mRNAs having specific affinity to a target compound from an RNA library using SELEX; and conforming mRNA specific to an abnormal cell by hybridizing the selected mRNAs with normal cell DNA or on a DNA chip where normal cell cDNA.
Abstract translation: 目的：提供一种通过使用亲和力选择，通过使用人类基因组基因容易且快速地鉴定新的mRNA从mRNA文库中选择新的靶mRNA的方法。 构成：通过使用亲和力选择从mRNA文库中选择新的靶mRNA的方法包括以下步骤：使用SELEX从RNA文库中选择对目标化合物具有特异亲和力的mRNA; 并通过将所选择的mRNA与正常细胞DNA或正常细胞cDNA的DNA芯片杂交，使异常细胞特异性的mRNA符合。
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公开(公告)号：KR1020020080939A
公开(公告)日：2002-10-26
申请号：KR1020010020813
申请日：2001-04-18
Applicant: 한국과학기술연구원
IPC: C07K16/18
CPC classification number: C07K16/18 , C07K2317/565
Abstract: PURPOSE: Catalytic antibodies with N-glycosidase activity are provided, therefore various complex sugar molecules can be easily treated, and they can be useful in studies on the formation and decomposition of sugars. CONSTITUTION: The catalytic antibodies with N-glycosidase activity have a light chain represented by the nucleotide sequence of SEQ ID NO: 1 and a heavy chain represented by the nucleotide sequence of SEQ ID NO: 2 and the light chain and the heavy chain are connected by a linker. A DNA molecule encoding a single chain catalytic antibody comprises the catalytic antibody with N-glycosidase activity consisting of the light chain represented by the nucleotide sequence of SEQ ID NO: 1 and the heavy chain represented by the nucleotide sequence of SEQ ID NO: 2, and the linker represented by the nucleotide sequence of SEQ ID NO: 3.
Abstract translation: 目的：提供具有N-糖苷酶活性的催化抗体，因此可以容易地处理各种复杂的糖分子，并且它们可用于研究糖的形成和分解。 构成：具有N-糖苷酶活性的催化抗体具有由SEQ ID NO：1的核苷酸序列表示的轻链和由SEQ ID NO：2的核苷酸序列表示的重链，轻链和重链连接 通过链接器。 编码单链催化抗体的DNA分子包含具有由SEQ ID NO：1的核苷酸序列表示的轻链和由SEQ ID NO：2的核苷酸序列表示的重链的N-糖苷酶活性的催化抗体， 和由SEQ ID NO：3的核苷酸序列表示的接头。
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公开(公告)号：KR1020020080691A
公开(公告)日：2002-10-26
申请号：KR1020010020421
申请日：2001-04-17
Applicant: 한국과학기술연구원
IPC: C07K7/08
CPC classification number: C07K7/08
Abstract: PURPOSE: Provided are carbohydrate-specific peptides which have a strong affinity and a preparation method thereof. In particular, the carbohydrate-specific peptides are prepared by the multiple bond of peptides having a carbohydrate-specific sequence to increase an affinity. CONSTITUTION: The carbohydrate-specific peptides which have a strong affinity is characteristically prepared by the steps of; finding out peptides, which bind to carbohydrates, on the surface of a cell; and preparing peptides having a strong affinity to carbohydrates being on the surface of a cell by manufacturing a polymer of the peptides, wherein the polymer is manufactured by linking an amino acid having at least two amino residues to a peptide.
Abstract translation: 目的：提供具有强亲和力的碳水化合物特异性肽及其制备方法。 特别地，通过具有碳水化合物特异性序列的肽的多重键来制备碳水化合物特异性肽以增加亲和力。 构成：具有强亲和力的碳水化合物特异性肽通过以下步骤特征性地制备： 在细胞表面发现结合碳水化合物的肽; 并且通过制备肽的聚合物制备对碳水化合物具有强亲和力的肽，其中所述聚合物通过将具有至少两个氨基残基的氨基酸连接到肽来制备。
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公开(公告)号：KR100341827B1
公开(公告)日：2002-06-26
申请号：KR1020000004480
申请日：2000-01-29
Applicant: 한국과학기술연구원
IPC: C07K16/00
Abstract: 본발명은 시험관적 면역법을 사용하여 아미노-RNA에 대한 항체 및 이를 제조하는 방법을 제공하여, 일반 RNA로 생체면역법을 이용하여 생성할 수 없는 RNA에 대한 항체를 비교적 안정한 아미노-RNA로서 시험관내 면역법으로 생산할 수 있으며, 또한 얻어진 항체는 자가면역질환의 특정 자가항체와 특이적이고 강하게 결합하여 자기면역질환을 방지할 수 있어 자기면역질환 치료제로 유용하고, 또한 아미노-RNA를 생체내로 투여하여 이에 대한 항체의 생성을 유발할 수 있어 자가면역질환에 대한 백신제로 개발가능하다.
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公开(公告)号：KR1020010076989A
公开(公告)日：2001-08-17
申请号：KR1020000004479
申请日：2000-01-29
Applicant: 한국과학기술연구원
IPC: C12N15/00
Abstract: PURPOSE: A RNA molecule binding specifically to an antibody specific to anti-DNA is provided, which can be used as a therapeutic agent suppressing the antibody specific to anti-DNA in auto immune disease, since the selected RNA neutralizes the autoantibody sufficiently. CONSTITUTION: A RNA molecule binding specifically to an antibody specific to anti-DNA that causes auto immune disease is selected from the group consisting of sequence ID. No.1 to sequence ID.No.14. It shows bindability 10000 times as strong as double strand DNA and binds to an antibody specific to anti-DNA according to competitive ELISA analysis and immunoprecipitation analysis.
Abstract translation: 目的：提供特异性结合抗DNA特异性抗体的RNA分子，因为所选择的RNA能够充分中和自身抗体，可用作抑制自身免疫疾病中抗DNA特异性抗体的治疗剂。 构成：特异性结合引起自身免疫疾病的抗DNA特异性抗体的RNA分子选自序列ID。 序号为1号。 它显示出与双链DNA相当强的10000倍的结合能力，并根据竞争性ELISA分析和免疫沉淀分析结合抗DNA特异性抗体。
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