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公开(公告)号：BRPI0615026A2
公开(公告)日：2009-06-16
申请号：BRPI0615026
申请日：2006-08-18
Applicant: ABBOTT LAB
Inventor： WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
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公开(公告)号：MX2008012482A
公开(公告)日：2008-10-10
申请号：MX2008012482
申请日：2007-04-02
Applicant: ABBOTT LAB
Inventor： CALDERWOOD DAVID J , WISHART NEIL , DIXON RICHARD W , ERICSSON ANNA M , LI BIQIN , GORDON THOMAS D , BARBERIS CLAUDE E , TALANIAN ROBERT V , FRANK KRISTINE E , BURCHAT ANDREW , ABBOTT LILY K , ARGIRIADI MARIA A , BORHANI DAVID W , CUSACK KEVIN P , MULLEN KELLY D , WU XIAOYUN , ZHANG XIAOLEI , WANG LU X
IPC: A61K31/5377
Abstract: Se describen nuevos compuestos de fórmula (I) o sales farmacéuticamente aceptables, profármacos y metabilitos biológicamente activos de los mismos de fórmula (I), en donde los sustituyentes son según lo definido en la presente, los cuales son útiles como agentes terapéuticos.
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公开(公告)号：CA2681739A1
公开(公告)日：2008-10-02
申请号：CA2681739
申请日：2008-03-27
Applicant: ABBOTT LAB
Inventor： FRANK KRISTINE E , CALDERWOOD DAVID J , BETSCHMANN PATRICK , BREINLINGER ERIC C , DIXON RICHARD W
IPC: A01N43/58 , A61K31/50 , C07D471/00
Abstract: The present invention is directed to novel imidazopyrazine compounds usef ul as kinase inhibitors and as such would be useful in treating certain cond itions and diseases, especially inflammatory conditions and diseases and pro liferative disorders and conditions, for example, cancers.
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公开(公告)号：CA2560691A1
公开(公告)日：2005-10-13
申请号：CA2560691
申请日：2005-03-24
Applicant: MAKOTO AOYAMA , ABBOTT LAB
Inventor： WADA CAROL K , STEINMAN DOUGLAS H , RAFFERTY PAUL , MAKOTO AOYAMA , XIA ZHIREN , MICHAELIDES MICHAEL R , MUCKEY MELANIE A , DINGES JUERGEN , HOLMS JAMES H , ZHANG HENRY Q , AKRITOPOULOU-ZANZE IRINI , DIXON RICHARD W , DJURIC STEVAN W , ERICSSON ANNA M , FISCHER KIMBA , GRACIAS VIJAYA J , ARNOLD LEE D , GASIECKI ALAN F
IPC: C07D409/04 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P35/00 , A61P37/00 , C07D231/54 , C07D409/14 , C07D413/14 , C07D491/04 , C07D495/04
Abstract: Compounds of the present invention are useful for inhibiting protein tyrosin e kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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公开(公告)号：HU0300423A2
公开(公告)日：2003-06-28
申请号：HU0300423
申请日：2001-02-09
Applicant: ABBOTT LAB
Inventor： BROCKLEHURST SIMON MARK , DIXON RICHARD W , DUNCAN ALEXANDER ROBERT , GHAYUR TARIQ , LABKOVSKY BORIS , LENNARD SIMON NICHOLAS , MANKOVICH JOHN , ROGUSKA MIKE , SALFELD JOCHEN , SHORROCK CELIA PATRICIA , THOMPSON JULIA ELIZABETH , WHITE MICHAEL
IPC: A61K39/395 , C12N15/02 , A61K45/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/02 , A61P7/06 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P39/00 , A61P39/02 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
Abstract: Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular, antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-I8 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
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Patent Agency Ranking
公开(公告)号：SK12942002A3
公开(公告)日：2003-05-02
申请号：SK12942002
申请日：2001-02-09
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , DIXON RICHARD W , ROGUSKA MIKE , WHITE MICHAEL , LABKOVSKY BORIS , SALFELD JOCHEN , DUNCAN ALEXANDER ROBERT , BROCKLEHURST SIMON MARK , MANKOVICH JOHN , SHORROCK CELIA PATRICIA , THOMPSON JULIA ELIZABETH , LENNARD SIMON NICHOLAS
IPC: A61K39/395 , C12N15/02 , A61K45/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/02 , A61P7/06 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P39/00 , A61P39/02 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , C07K16/00
Abstract: Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular, antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-I8 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
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公开(公告)号：CA2800450A1
公开(公告)日：2001-08-16
申请号：CA2800450
申请日：2001-02-09
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , DIXON RICHARD W , ROGUSKA MIKE , WHITE MICHAEL , LABKOVSKY BORIS , SALFELD JOCHEN , DUNCAN ALEXANDER ROBERT , BROCKLEHURST SIMON MARK , MANKOVICH JOHN , SHORROCK CELIA PATRICIA , THOMPSON JULIA ELIZABETH , LENNARD SIMON NICHOLAS
IPC: C07K16/24 , C12N15/02 , A61K39/395 , A61K45/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/02 , A61P7/06 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P39/00 , A61P39/02 , C07K1/22 , C07K14/54 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12P21/08 , C40B30/04
Abstract: Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular, antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-I8 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
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公开(公告)号：UA102503C2
公开(公告)日：2013-07-25
申请号：UAA200903345
申请日：2007-09-07
Applicant: ABBOTT LAB
Inventor： WU CHENGBIN , DIXON RICHARD W , BELK JONATHAN P , YING HUA , ARGIRIADI MARIA A , CUFF CAROLYN A , HINTON PAUL R , KUMAR SHANKAR , MELIM TERRY L , CHEN YAN
Abstract: Изобретениеотноситсяк белку (антителу), способномусвязыватьсяс IL-13, конъюгатуантитела, выделенноймолекуленуклеиновойкислоты, вектору, клетке-хозяина, способуполучениябелка. Изобретениетакжеотноситсяк фармацевтическойкомпозиции, способулеченияу индивидазаболеванияилинарушения, вкоторомактивность IL-13 отрицательновлияетназдоровье, способууменьшенияактивности IL-13 уиндивидаи т.п.
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公开(公告)号：CR20130157A
公开(公告)日：2013-05-23
申请号：CR20130157
申请日：2013-04-03
Applicant: ABBOTT LAB
Inventor： LACY SUSAN E , FUNG EMMA , BELK JONATHAN P , DIXON RICHARD W , ROGUSKA MICHAEL , HINTON PAUL R , KUMAR SHANKAR
IPC: C07K16/00
Abstract: Proteínas de unión a IL-12 p40, en particular anticuerpos que se unen a la interleuquina-12 humana (hIL-12) y/o IL-23 humana (hIL-23). Específicamente, la invención se relaciona con anticuerpos que son quiméricos, con injertos de CDR y anticuerpos humanizados.
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公开(公告)号：NO20091411A
公开(公告)日：2009-05-22
申请号：NO20091411
申请日：2009-04-07
Applicant: ABBOTT LAB
Inventor： HINTON PAUL R , BELK JONATHAN P , DIXON RICHARD W , KUMAR SHANKAR , WU CHENGBIN , YING HUA , ARGIRIADI MARIA A , CUFF CAROLYN A , MELIM TERRY L , CHEN YAN
CPC classification number: A61K45/06 , A61K38/00 , A61K39/3955 , C07K14/47 , C07K16/244 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/463 , Y02A50/473 , Y02A50/478 , Y02A50/481
Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
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