公开(公告)号：AT236185T

公开(公告)日：2003-04-15

申请号：AT97922483

申请日：1997-04-25

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  CURTY CYNTHIA BRUNELL ,  FAGHIH RAMIN ,  NELLANS HUGH NERBY ,  PETERSEN ALBERT CHRISTIAN

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P1/18 ,  A61P3/00 ,  A61P3/04 ,  A61P43/00 ,  C07H17/08

Abstract: Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having the Formula (I) (I) and pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.

公开(公告)号：PT802920E

公开(公告)日：2002-03-28

申请号：PT96903378

申请日：1996-01-03

Applicant: ABBOTT LAB

Inventor： KLEIN LARRY L ,  MCALPINE JAMES B ,  JACKSON MARIANNA ,  LARTEY PAUL A ,  HOCHLOWSKI JILL E ,  ALDER LISA A ,  BURRES NEAL S ,  YEUNG CLINTON

IPC: C12P17/06 ,  A01N43/16 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  A61P31/10 ,  C07H15/10 ,  C07H17/04 ,  C12R1/645

公开(公告)号：AT206431T

公开(公告)日：2001-10-15

申请号：AT96903378

申请日：1996-01-03

Applicant: ABBOTT LAB

Inventor： ALDER LISA A ,  BURRES NEAL S ,  HOCHLOWSKI JILL E ,  JACKSON MARIANNA ,  MCALPINE JAMES B ,  KLEIN LARRY L ,  LARTEY PAUL A ,  YEUNG CLINTON

IPC: C12P17/06 ,  A01N43/16 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  A61P31/10 ,  C07H15/10 ,  C07H17/04 ,  C12R1/645

公开(公告)号：DE69317877D1

公开(公告)日：1998-05-14

申请号：DE69317877

申请日：1993-01-19

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  NELLANS HUGH N ,  KLEIN LARRY L ,  FAGHIH RAMIN

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P31/04 ,  C07D233/22 ,  C07H17/08

Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.

公开(公告)号：ZA9707207B

公开(公告)日：1998-02-20

申请号：ZA9707207

申请日：1997-08-12

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  KLEIN LARRY LEWIS ,  THOMAS SHEELA ALBERT ,  DEGOEY DA ALLEN ,  LI LEPING ,  LEONE CHRISTINA LOUISE ,  YEUNG MING CLIN ,  GRAMPOVNIK DAVID J

IPC: A61K38/00 ,  C07K7/56 ,  A61K ,  C07K

CPC classification number: C07K7/56 ,  A61K38/00

公开(公告)号：AU4748496A

公开(公告)日：1996-07-31

申请号：AU4748496

申请日：1996-01-03

Applicant: ABBOTT LAB

Inventor： ALDER LISA A ,  BURRES NEAL S ,  HOCHLOWSKI JILL E ,  JACKSON MARIANNA ,  MCALPINE JAMES B ,  KLEIN LARRY L ,  LARTEY PAUL A ,  YEUNG CLINTON

IPC: C12P17/06 ,  A01N43/16 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  A61P31/10 ,  C07H15/10 ,  C07H17/04 ,  C12R1/645

公开(公告)号：CA1328258C

公开(公告)日：1994-04-05

申请号：CA601931

申请日：1989-06-06

Applicant: ABBOTT LAB

Inventor： PARIZA RICHARD J ,  LARTEY PAUL A ,  MARING CLARENCE J ,  KLEIN LARRY L

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  C07H19/04 ,  A61K31/71

Abstract: 9-R-AZACYCLIC ERYTHROMYCIN ANTIBIOTICS Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

公开(公告)号：MX9300278A

公开(公告)日：1993-12-31

申请号：MX9300278

申请日：1993-01-19

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  FAGHIH RAMIN ,  KLEIN LARRY L ,  NELLANS HUGH N

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P31/04 ,  C07D233/22 ,  C07H17/08

Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.

公开(公告)号：CA2125478A1

公开(公告)日：1993-07-22

申请号：CA2125478

申请日：1993-01-19

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  NELLANS HUGH N ,  KLEIN LARRY L ,  FAGHIH RAMIN

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P31/04 ,  C07D233/22 ,  C07H17/08

Abstract: 2125478 9313780 PCTABS00024 4''-Deoxy derivatives of erythromycin having formula (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.

公开(公告)号：IE921109A1

公开(公告)日：1992-11-04

申请号：IE921109

申请日：1992-04-07

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  FEGHIH RAMIN ,  NINNO SHARI DE

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07D407/00

Abstract: Antibacterial compounds are disclosed having the formula and pharmaceutically acceptable salts thereof, wherein R1 is -NR4R6, where R4 and R6 are independently selected from the group consisting of hydrogen, loweralkyl and arylalkyl or, together, R4 and R6 form a nitrogen-containing heterocycle attached at the nitrogen atom; R2 is selected from the group consisting of hydrogen, -OH and, when R3 is methylene, oxygen so as to form an epoxide; and R3 is selected from the group consisting of -CH2OH, -NR4R6, -(CH2)nNR4R6 and, when R2 is oxygen, methylene so as to form an epoxide, where n is 1-4 and R4 and R6 are as previously defined, with the proviso that when R2 is -OH, R3 may not be -NR4R6; or R2 and R3 together are=CH2. Also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.