公开(公告)号：DE10029201A1

公开(公告)日：2001-12-20

申请号：DE10029201

申请日：2000-06-19

Applicant: BASF AG

Inventor： KOLTER KARL ,  FLICK DIETER ,  ASCHERL HERMANN

IPC: A61K47/32 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K47/04 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61P3/02 ,  A61K31/52

Abstract: Production of an oral dosage form (I) providing retarded active agent release, comprising: (a) a formulated mixture of polyvinyl acetate and polyvinyl pyrrolidone; (b) active agent(s); (c) optionally water-soluble polymers or lipophilic additives; and (d) optionally further conventional auxiliaries, involves granulating a mixture of (a), (b) and optionally (c) and/or (d) under heating at 40-130 degrees C. Production of an oral dosage form (I) providing retarded active agent release, comprising: (a) a formulated mixture of polyvinyl acetate (PVAc) and polyvinyl pyrrolidone (PVP); (b) active agent(s); (c) optionally water-soluble polymers or low or high molecular lipophilic additives; and (d) optionally further conventional auxiliaries, (e) involves granulating a mixture of (a), (b) and optionally (c) and/or (d) under heating at 40-130 degrees C. Independent claims are included for: (i) the obtained oral formulations (I); (ii) retarded release medicaments containing (I).

公开(公告)号：NO20015465A

公开(公告)日：2001-11-09

申请号：NO20015465

申请日：2001-11-08

Applicant: BASF AG

Inventor： SCHAEFER BERND ,  HARMS GUIDO ,  ASCHERL HERMANN ,  KREI GEORG ARNOLD

IPC: C12N9/99 ,  A61K38/00 ,  A61P7/02 ,  A61P9/00 ,  A61P25/00 ,  A61P35/00 ,  C07K5/065 ,  A61K38/05 ,  C07K1/14

CPC classification number: C07K5/06078 ,  A61K38/00

公开(公告)号：AT202075T

公开(公告)日：2001-06-15

申请号：AT97119147

申请日：1997-11-03

Applicant: BASF AG

Inventor： SCHOENHERR MICHAEL DR ,  RAULS MATTHIAS DR ,  ASCHERL HERMANN ,  LETZELTER THOMAS ,  BAUMANN DIETER ,  POTTHOFF-KARL BIRGIT DR

IPC: C11D1/04 ,  C07C227/42 ,  C07C229/16 ,  C07C229/24

Abstract: A method for the preparation of a crystalline solid comprising a glycine-N,N-diacetic acid derivative of formula (I) with a very low hygroscopicity, comprises fixing the water content of the starting material containing (I) at 10-30 wt.% and then carrying out crystallisation: MOOC-CH(R)-N(CH2COOM)2 (I) R = 1-30C alkyl or 2-30C alkenyl (both optionally containing 1-5 OH, formyl, 1-4C alkoxy(carbonyl) or phenoxy groups and/or optionally containing up to 5 non-adjacent O atoms in the chain), alkoxylate groups of formula (II), phenyl-(1-20 C)-alkyl (optionally containing up to 3 1-4C alkyl, OH, carboxyl, sulpho or 1-4C alkoxycarbonyl ring substituents), 5- or 6-membered optionally benzalated heterocyclic ring containing up to 3 N, O or S atoms (optionally containing up to 3 1-4C alkyl, OH, carboxyl, sulpho or 1-4C alkoxycarbonyl substituents) or a group of formula (III): -(CH2)k-O-(A O)m-(A O)n-Y (II) -A-CH(COOM)-N(CH2COOM)2 (III) A , A = 2-4C 1,2-alkylene; Y = H, 1-12C alkyl, phenyl or 1-4C alkoxycarbonyl; k = 1-3; m, n = 0-50; A = 1-12C alkylene or single bond; and M = H, alkali(ne earth) metal or optionally substituted ammonium, with the provision that m+n = at least 4.

公开(公告)号：AU4560900A

公开(公告)日：2000-11-21

申请号：AU4560900

申请日：2000-05-03

Applicant: BASF AG

Inventor： SCHAFER BERND ,  HARMS GUIDO ,  ASCHERL HERMANN ,  KREI GEORG ARNOLD

IPC: C12N9/99 ,  A61K38/00 ,  A61P7/02 ,  A61P9/00 ,  A61P25/00 ,  A61P35/00 ,  C07K5/065 ,  C07K5/06 ,  C07K1/14 ,  A61K31/40 ,  A61K31/44

Abstract: The invention relates to a process for preparing constant-weight thrombin inhibitors of the formula Iwhere n is 0, 1, 2, and tautomers thereof,wherein an aqueous solution of the active substance is spray dried.

公开(公告)号：CA2218921A1

公开(公告)日：1998-05-29

申请号：CA2218921

申请日：1997-11-12

Applicant: BASF AG

Inventor： POTTHOFF-KARL BIRGIT ,  BAUMANN DIETER ,  LETZELTER THOMAS ,  ASCHERL HERMANN ,  SCH NHERR MICHAEL ,  RAULS MATTHIAS

IPC: C11D1/04 ,  C07C227/42 ,  C07C229/16 ,  C07C229/24 ,  C07C229/04 ,  C11D1/10 ,  C07D211/34 ,  C07C303/42 ,  C07D307/54 ,  C07D213/55 ,  C07C309/61

Abstract: A crystalline solid which has a sufficiently low hygroscopicity for processing and use and essentially consists of glycine-N,N-diacetic acid derivatives is prepared by adjusting the water content of the starting material containing the glycine-N,N-diacetic acid derivatives to a value of from 10 to 30% by weight, based on the starting material, and subsequently bringing about crystallization. .

公开(公告)号：DE3938528A1

公开(公告)日：1991-05-23

申请号：DE3938528

申请日：1989-11-21

Applicant: BASF AG

Inventor： DIETRICH GERHARD DR ,  BORHO KLAUS DR ,  SARTOR KARL-HEINZ ,  SCHLINDWEIN HEINZ ,  ASCHERL HERMANN ,  GRAMMATIS ZAFIRIOS DR ,  NIESSNER MANFRED DR

IPC: B01J19/00 ,  B01J19/18 ,  C07C213/00 ,  C07C213/02 ,  C07C219/08 ,  C07C231/12 ,  C07C233/38

公开(公告)号：CA2670113A1

公开(公告)日：2008-06-05

申请号：CA2670113

申请日：2007-11-23

Applicant: BASF AG

Inventor： DIELEMAN CEDRIC ,  KOLTER KARL ,  ASCHERL HERMANN ,  SCHOENHERR MICHAEL ,  KOLTZENBURG SEBASTIAN ,  KNIERIEM TORSTEN ,  TUERK HOLGER

IPC: A01N25/12 ,  A01N25/10 ,  A01N43/653 ,  A01N47/24

Abstract: The invention relates to a method for production of solid solutions of po orly soluble pesticides, power products obtained by such a method and the us e thereof for pesticide formulations.

公开(公告)号：DE50111767D1

公开(公告)日：2007-02-15

申请号：DE50111767

申请日：2001-03-06

Applicant: BASF AG

Inventor： KOLTER KARL DR ,  SCHOENHERR MICHAEL DR ,  ASCHERL HERMANN

IPC: A61K9/22 ,  A61K47/32 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/24 ,  A61K47/34 ,  A61K47/38 ,  A61P3/02

Abstract: The present invention relates to oral dosage forms with delayed release of active ingredient and high mechanical stability, comprising a) one or more active ingredients b) a formulated mixture of polyvinyl acetate and polyvinylpyrrolidone c) water-soluble polymers or low or high molecular weight lipophilic additives d) and other conventional excipients, and to the use and production thereof.

公开(公告)号：AT350018T

公开(公告)日：2007-01-15

申请号：AT01105547

申请日：2001-03-06

Applicant: BASF AG

Inventor： KOLTER KARL DR ,  SCHOENHERR MICHAEL DR ,  ASCHERL HERMANN

IPC: A61K47/32 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K9/28 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/24 ,  A61K47/34 ,  A61K47/38 ,  A61P3/02

Abstract: The present invention relates to oral dosage forms with delayed release of active ingredient and high mechanical stability, comprising a) one or more active ingredients b) a formulated mixture of polyvinyl acetate and polyvinylpyrrolidone c) water-soluble polymers or low or high molecular weight lipophilic additives d) and other conventional excipients, and to the use and production thereof.

公开(公告)号：DE102005025855A1

公开(公告)日：2006-12-14

申请号：DE102005025855

申请日：2005-06-06

Applicant: BASF AG

Inventor： SCHNEIDER JOERG ,  SCHERR GUENTER ,  ERHARDT RAINER ,  EICHFELDER ANDREAS ,  REIF MARTIN ,  HIRSCH STEFAN ,  SIEDER GEORG ,  HOLTMANN THOMAS ,  CIPRIAN JUERGEN ,  ASCHERL HERMANN

IPC: C07D251/18 ,  A61K31/53

Abstract: The invention relates to a process for preparing free-flowing, pulverulent alkoxycarbonylaminotriazine from an alkanolic reaction mixture which is obtained in the preparation of alkoxycarbonylaminotriazines and comprises at least one alkoxycarbonylaminotriazine, at least one cyclic and/or acyclic carbonic ester, at least one C1-C13-alkanol which optionally comprises one or two oxygen atoms in the form of ether bonds and is optionally substituted by C1-C4-alkyl and/or hydroxyl, and also at least one alkali metal or alkaline earth metal alkoxide, with or without melamine and with or without catalyst, by atomizing and drying the reaction mixture in a spray drier.