公开(公告)号：CA2312917A1

公开(公告)日：1999-06-17

申请号：CA2312917

申请日：1998-12-09

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  MAIER WERNER ,  TRAPP BURKHARD ,  JOTTER KARL LUDWIG ,  ROSENBERG JOERG ,  KRULL HARALD ,  FARWERCK KARL-PETER ,  LANGE ARMIN ,  KLEINKE ANDREAS ,  JOCHUM ALFONS

IPC: A61K9/16 ,  B01J2/20 ,  B29B9/06 ,  B30B9/28 ,  B30B11/22 ,  C05G3/00

Abstract: The invention relates to an extrusion device, particularly an extrusion device for thermoplastic or dough-like masses or highly tenacious melts, and to the use of said device. The extrusion device has a housing (11), at least one conveyor worm (12) arranged in a housing and an outlet (20) disposed on the front face of the housing (11) close to the end of each conveyor screw which is furthest away from the drive end. At least one stripping member (21) is arranged in between the end (14) of each conveyor screw (12) furthest away from the drive end and the outlet (20). The device is particularly suitable for producing granulates, preferably those containing active substances.

公开(公告)号：IN182500B

公开(公告)日：1999-04-17

申请号：IN1824MA1996

申请日：1996-10-16

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  HARTL AXEL PAUL ,  HOFMANN JURGEN ,  ROSENBERG JOERG ,  SCHIEBL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K9/00

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：ZA978219B

公开(公告)日：1999-03-12

申请号：ZA978219

申请日：1997-09-12

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  KLEINKE ANDREAS ,  KOTHRADE STEFAN ,  ROSENBERG JOERG

IPC: A61K9/20 ,  A61K

公开(公告)号：ZA976363B

公开(公告)日：1999-01-19

申请号：ZA976363

申请日：1997-07-18

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/16 ,  A61K9/20 ,  A61K36/00 ,  A61K36/16 ,  A61K36/38 ,  A61K36/48 ,  A61K36/61 ,  A61K

公开(公告)号：DE59503813D1

公开(公告)日：1998-11-05

申请号：DE59503813

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JOERG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05117 Sec. 371 Date Jun. 18, 1997 Sec. 102(e) Date Jun. 18, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19962 PCT Pub. Date Jul. 4, 1996A process for the production of divisible tablets by melt calendering in which two molding rolls are combined together, at least one of which has depressions with at least one bar which extends up to the surface line of the molding roll and forms a score.

公开(公告)号：ZA9700515B

公开(公告)日：1998-07-22

申请号：ZA9700515

申请日：1997-01-22

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  ROSENBERG JOERG

IPC: A61K47/04 ,  A61K9/20 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K45/00 ,  A61K47/32 ,  A61P25/00 ,  A61P29/00 ,  A61K

CPC classification number: A61K31/192 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2095

公开(公告)号：SK104397A3

公开(公告)日：1998-04-08

申请号：SK104397

申请日：1996-02-01

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  BREITENBACH JORG ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/22 ,  A61K9/20

Abstract: PCT No. PCT/EP96/00417 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 1, 1996 PCT Pub. No. WO96/25151 PCT Pub. Date Aug. 22, 1996Solid preparations are obtainable by melt extrusion of A) at least one active compound, B) a mixture of B1) from 10 to 90% by weight of a water-soluble, thermoplastic polymer, and B2) from 10 to 90% by weight of a low-substituted hydroxypropylcellulose, and C) from 0 to 50% by weight, based on the total amount of the preparation, of customary pharmaceutical auxiliaries.

公开(公告)号：ZA968134B

公开(公告)日：1998-03-27

申请号：ZA968134

申请日：1996-09-27

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JOERG

IPC: A61K9/20 ,  A61K ,  A61J

公开(公告)号：AU688328B2

公开(公告)日：1998-03-12

申请号：AU6926394

申请日：1994-05-09

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  MUELLER WINFRIED ,  ROSENBERG JOERG ,  BINDER RUDOLF ,  SANNER AXEL

IPC: A61K47/32 ,  A61K9/14 ,  A61K31/37 ,  A61K31/41 ,  A61K31/425 ,  A61K31/433 ,  A61K47/30 ,  A61K47/38

Abstract: PCT No. PCT/EP94/01489 Sec. 371 Date Nov. 7, 1995 Sec. 102(e) Date Nov. 7, 1995 PCT Filed May 9, 1994 PCT Pub. No. WO94/26267 PCT Pub. Date Nov. 24, 1994Compositions in the form of solid solutions containing a) 1-90% by weight of a coumarin derivative A from the group of alkoxycoumarins with a heterocyclic substituent or of hydroxycoumarins esterified with a sulfonic acid as active substance and b) 10-99% by weight of at least one water-soluble polymer B as carrier substance.

公开(公告)号：MX9706652A

公开(公告)日：1997-11-29

申请号：MX9706652

申请日：1996-03-09

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  SANNER AXEL ,  ROSENBERG JOERG

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K47/30 ,  A61K09/00 ,  A61K09/20

Abstract: La presente invencion se refiere a las composiciones transparentes para sustancia activas de liberacion rápida obtenibles por extrusion de masas fundidas, que contienen analgésicos no esteroidales, homopolímeros de N-vinilpirrolidona, sacáridos o alcoholes grasos y sales de sodio o de potasio.