公开(公告)号：ZA977399B

公开(公告)日：1999-02-18

申请号：ZA977399

申请日：1997-08-18

Applicant: BASF AG

Inventor： BRUCHMANN BERND ,  REIF MARTIN ,  HOFSCHEUER WERNER ,  JAEHME JOACHIM ,  LANGER WERNER ,  RENZ HANS ,  MOHRHARDT GUENTER ,  SCHIESSL MICHAEL

IPC: C07C273/18 ,  C07C275/62 ,  C08G18/08 ,  C08G18/30 ,  C08G18/32 ,  C08G18/78 ,  C08G ,  C09D ,  C08J

Abstract: A process for preparing biuret-functional polyisocyanates from at least one aliphatic or cycloaliphatic diisocyanate and from at least one amine or water or a mixture thereof as reactants involves mixing the reactants with one another in a mixing unit having a high shear action.

公开(公告)号：BG102313A

公开(公告)日：1998-10-30

申请号：BG10231398

申请日：1998-03-10

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  HAERTL AXEL P ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS D

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: The invention relates to a method where at least two massesare simultaneously extruded each containing a thermoplastic,pharmacologically acceptable and physiological medium-soluble orexpanding polymer binder, at least one of them also including apharmaceutically active substance. The co-extruded multilayermaterial is moulded to the desired medicamentous form.10 claims

公开(公告)号：CZ9801242A3

公开(公告)日：1998-07-15

申请号：CZ124298

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JORG DR ,  HARTL AXEL PAUL DR ,  HOFMANN JURGEN ,  ROSENBERG JOERG DR ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

CPC classification number: A61J3/10 ,  A61J2200/20 ,  A61K9/209 ,  A61K9/2095 ,  A61K9/2893 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/616 ,  B30B11/14 ,  B30B11/16 ,  B30B11/18 ,  B30B11/34 ,  B30B15/308 ,  A61K31/19 ,  A61K2300/00

公开(公告)号：AU7001998A

公开(公告)日：1998-05-29

申请号：AU7001998

申请日：1997-10-28

Applicant: BASF AG

Inventor： BAUMGARTEL MICHAEL ,  DEMBEK GERHARD ,  HAHN KLAUS ,  HOLOCH JAN ,  HUSEMANN WOLFRAM ,  KAEMPFER KNUT ,  LAY PETER ,  RUCK SWEN ,  SCHIESSL MICHAEL ,  WITT MICHAEL

IPC: C08F257/02 ,  C08J9/20

公开(公告)号：NO981798L

公开(公告)日：1998-04-22

申请号：NO981798

申请日：1998-04-22

Applicant: BASF AG

Inventor： BREITENBACH JAERG ,  HORTL AXEL PAUL ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61K9/16 ,  A61K9/20

公开(公告)号：NO981793A

公开(公告)日：1998-04-22

申请号：NO981793

申请日：1998-04-22

Applicant: BASF AG

Inventor： BREITENBACH JUERG ,  HORTL AXEL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K9/02

CPC classification number: A61J3/10 ,  A61J2200/20 ,  A61K9/209 ,  A61K9/2095 ,  A61K9/2893 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/616 ,  B30B11/14 ,  B30B11/16 ,  B30B11/18 ,  B30B11/34 ,  B30B15/308 ,  A61K31/19 ,  A61K2300/00

公开(公告)号：NO980736D0

公开(公告)日：1998-02-20

申请号：NO980736

申请日：1998-02-20

Applicant: BASF AG

Inventor： LAY PETER NICOLAUS ,  RUECK SWEN ,  SCHIESSL MICHAEL ,  WITT MICHAEL ,  ZETTLER HANS DIETER ,  BAUMGAERTEL MICHAEL ,  DEMBEK GERHARD ,  HAHN KLAUS ,  HOLOCK JAN ,  HUSEMANN WOLFRAM ,  KAEMPFER KNUT

IPC: C08J9/16 ,  B01J13/14 ,  B01J19/18 ,  B01J19/24 ,  C08F2/02 ,  C08F2/18 ,  C08F12/08 ,  C08F ,  C08J

Abstract: PCT No. PCT/EP96/03633 Sec. 371 Date Jan. 29, 1998 Sec. 102(e) Date Jan. 29, 1998 PCT Filed Aug. 19, 1996 PCT Pub. No. WO97/08231 PCT Pub. Date Mar. 6, 1997A continuous process for preparing bead-form expandable styrene polymers in which the styrene is prepolymerized in bulk to a conversion of 10 to 80%, the prepolymer is dispersed in liquid form in an aqueous phase in the presence of suspension stabilizers, and the polymerization of the prepolymer is completed in an aqueous suspension to a residual styrene content of less than 2000 ppm.

公开(公告)号：DK0857062T3

公开(公告)日：2002-07-15

申请号：DK96937214

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  AXEL PAUL HAERTL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  HANS DIETER ZETTLER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：CZ289689B6

公开(公告)日：2002-03-13

申请号：CZ124298

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JORG DR ,  HARTL AXEL PAUL DR ,  HOFMANN JURGEN ,  ROSENBERG JOERG DR ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: The present invention relates to a process for preparing solid multilayer medicaments for oral or rectal administration, which preparation process comprises a) preparation of a first and a second mixtures, each first and second mixture contains thermoplastic and pharmacologically acceptable polymer binding agent that is soluble or swelling in a physiological medium and the first or the second or both the mixtures contain a pharmaceutically active component b) softening or grinding the first and second mixtures, c) passage of the first and second mixtures through a common co-extrusion die, d) extrusion of the first and second mixtures to obtain a co-extruded multilayer material and e) moulding of the co-extruded multilayer material to a desired medicament form.

公开(公告)号：DE59705295D1

公开(公告)日：2001-12-13

申请号：DE59705295

申请日：1997-08-18

Applicant: BASF AG

Inventor： BRUCHMANN BERND ,  REIF MARTIN ,  HOFSCHEUER WERNER ,  JAEHME JOACHIM ,  LANGER WERNER ,  RENZ HANS ,  MOHRHARDT GUENTER ,  SCHIESSL MICHAEL

IPC: C07C273/18 ,  C07C275/62 ,  C08G18/08 ,  C08G18/30 ,  C08G18/32 ,  C08G18/78

Abstract: A process for preparing biuret-functional polyisocyanates from at least one aliphatic or cycloaliphatic diisocyanate and from at least one amine or water or a mixture thereof as reactants involves mixing the reactants with one another in a mixing unit having a high shear action.