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    32.
    发明专利
    未知

    公开(公告)号：DE502005003587D1

    公开(公告)日：2008-05-15

    申请号：DE502005003587

    申请日：2005-09-22

    Applicant: BASF SE

    Inventor： JAEKEL CHRISTOPH ,  HEYDRICH GUNNAR ,  STUERMER RAINER ,  PACIELLO ROCCO

    IPC: C12P7/04

    Abstract: A process for preparing optically active 2-methylalkan-1-ol of the general formula (III) comprising the following steps: (i) carbonyl-selective reduction of 2-methylalk-2-en-1-al of the general formula (I) to 2-methylalk-2-en-1-ol of the general formula (II), (ii) enantioselective hydrogenation of 2-methylalk-2-en-1-ol to the general formula (iii), (iii) increasing the optical yield of the optically active 2-methylalkan-1-ol (III) obtained in step (ii) by a lipase-catalyzed acylation reaction, where the radical R means C1-C10-alkyl.

    33.
    发明专利
    未知

    公开(公告)号：AT391187T

    公开(公告)日：2008-04-15

    申请号：AT05787273

    申请日：2005-09-22

    Applicant: BASF SE

    Inventor： JAEKEL CHRISTOPH ,  HEYDRICH GUNNAR ,  STUERMER RAINER ,  PACIELLO ROCCO

    IPC: C12P7/04

    Abstract: A process for preparing optically active 2-methylalkan-1-ol of the general formula (III) comprising the following steps: (i) carbonyl-selective reduction of 2-methylalk-2-en-1-al of the general formula (I) to 2-methylalk-2-en-1-ol of the general formula (II), (ii) enantioselective hydrogenation of 2-methylalk-2-en-1-ol to the general formula (iii), (iii) increasing the optical yield of the optically active 2-methylalkan-1-ol (III) obtained in step (ii) by a lipase-catalyzed acylation reaction, where the radical R means C1-C10-alkyl.

    34.
    发明专利
    未知

    公开(公告)号：AT513054T

    公开(公告)日：2011-07-15

    申请号：AT06841443

    申请日：2006-12-19

    Applicant: BASF SE

    Inventor： SCHAEDLER ANDREAS ,  FRIEDRICH THOMAS ,  STUERMER RAINER ,  RINCK-JAHNKE SABINE

    IPC: C12P7/24 ,  C12N9/02

    Abstract: Preparation of an optically active saturated aldehyde or alcohol (II) comprises reduction of alpha , beta unsaturated aldehyde (I) with a polypeptide sequence (SEQ ID NO: 1 or 2), or a polypeptide sequence exhibiting at least 80% sequence identity of (SEQ ID NO: 1 or 2), in the presence of an enoate reductase. Preparation of an optically active saturated aldehyde or alcohol of formula (II) comprises reduction of alpha , beta unsaturated aldehyde (I) of formula (R 3>-C(R 2>)=C(R 1>)-CH(=O)) with a polypeptide sequence (SEQ ID NO: 1 or 2) (not defined), or a polypeptide sequence exhibiting at least 80% sequence identity of (SEQ ID NO: 1 or 2), in the presence of a enoate reductase. R 1>, R 2>H or 1-4C-alkyl; and R 3>H or 1-6C alkyl or alkenyl. [Image].

    36.
    发明专利
    未知

    公开(公告)号：DE502007001258D1

    公开(公告)日：2009-09-17

    申请号：DE502007001258

    申请日：2007-04-19

    Applicant: BASF SE

    Inventor： STUERMER RAINER ,  KROUTIL WOLFGANG ,  FABER KURT ,  GRUBER CHRISTIAN

    IPC: C12P7/02

    Abstract: A method for racemizing optically active secondary alcohols by incubating these alcohols with at least one alcohol dehydrogenase of the E.C. 1.1.1. class.

    37.
    发明专利
    未知

    公开(公告)号：DE502005007706D1

    公开(公告)日：2009-08-27

    申请号：DE502005007706

    申请日：2005-05-04

    Applicant: BASF SE

    Inventor： STUERMER RAINER ,  KESSELER MARIA ,  HAUER BERNHARD ,  FRIEDRICH THOMAS ,  BREUER MICHAEL ,  SCHROEDER HARTWIG

    IPC: C12P7/02 ,  C07D333/16 ,  C12N9/04 ,  C12P20060101 ,  C12P13/00 ,  C12P17/00

    Abstract: The invention relates to a method for producing the optically active alkanols of formula (I), wherein n is an integer of from 0 to 5; Cyc represents an optionally substituted, mononuclear or polynuclear, saturated or unsaturated, carbocylic or heterocyclic ring, and R1 represents halogen, SH, OH, NO2, NR2R3 or NR2R3R4+X−, wherein R2, R3 and R4 independently represent H or a lower alkyl or lower alkoxy group and X− represents a counterion. According to the invention, an enzyme (E) selected from the groups of dehydrogenases, aldehyde reductases and carbonyl reductases is incubated in a medium containing the alkanone of formula (II), wherein n, Cyc and R1 are defined as above, in the presence of reduction equivalents. The compound of formula (II) is enzymatically reduced to the compound of formula (I) and the reduction equivalents consumed during reaction are regenerated by reacting a sacrificial alcohol to the corresponding sacrificial ketone using enzyme (E) and at least partially removing the sacrificial ketone from the reaction medium, and then isolating the product (I) so produced.

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