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    METHOD FOR DETECTING CHLAMYDIA
    34.
    发明专利
    METHOD FOR DETECTING CHLAMYDIA 失效

    公开(公告)号：JPH05317097A

    公开(公告)日：1993-12-03

    申请号：JP12858192

    申请日：1992-05-21

    Applicant: FUSO PHARMACEUTICAL IND

    Inventor： UEMURA HIDETOSHI ,  KISHI YUICHIRO ,  YOSHIDA HIROSHI

    IPC: C12N15/09 ,  C12N15/00 ,  C12N15/10 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/01 ,  C12N15/11

    Abstract: PURPOSE:To obtain a new nucleotide having a basic sequence which is a part of main outer coat protein genes of Chlamydia, useful as a primer used in detection of microorganisms of the genus Chlamydia utilizing an amplifying method by a polymerase chain reaction. CONSTITUTION:A nucleotide having the sequence of the formula or a derivative obtained by carrying out at least one change comprising a change by removing 1 or 2 bases from the end on 5' side in the sequence of the formula or a change removing 1 or 2 bases from the end on 3' or change adding -T or -TA to the end and change replacing 1 or 2 bases other than both ends with other base selected from A, C, G and T. The nucleotide having sequence of the formula is obtained e.g. by synthesizing using a DNA synthesizer and then purifying with a high-performance liquid chromatography.

    NEW CALCIUM ANTAGONIST
    35.
    发明专利
    NEW CALCIUM ANTAGONIST 失效

    公开(公告)号：JP2000247891A

    公开(公告)日：2000-09-12

    申请号：JP5111499

    申请日：1999-02-26

    Applicant: FUSO PHARMACEUTICAL IND

    Inventor： TANAKA TOSHIO ,  SUGAYA JUNKO ,  KISHI YUICHIRO ,  MATSUKAWA AKIRA

    IPC: C07H19/10 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7072 ,  A61P7/00 ,  A61P7/02 ,  A61P43/00

    Abstract: PROBLEM TO BE SOLVED: To obtain a strong and safe calcium antagonist useful as a therapeutic medicine for ischemic heart diseases, e.g. cardiotonic agents or cardiac infarction by including an uridine alkylphosphate compound as an active ingredient. SOLUTION: This calcium antagonist comprises an uridine 5'-alkyl phosphate compound of the formula (R is an alkyl), e.g. uridine 5'-hexadecyl phosphate an active ingredient. The compound of the formula is obtained by dissolving, e.g. uridine 5'-monophosphate and an alkyl alcohol in tert-butyl alcohol and reacting uridine 5'-monophosphate in the presence of dicyclohexylcarbodiimide usually at 60-100 deg.C for 2-20 hr. The compound of the formula can be administered by oral, parenteral, transrectal or percutaneous administration and the compound is preferably administered to each of adult patients at a daily total dose of 1-2,000 mg in the case of oral administration and 0.1-400 mg in the case of parenteral administration.

    DETECTING METHOD OF HUMAN COMPLEMENT CONTROL FACTOR AND ITS USE
    36.
    发明专利
    DETECTING METHOD OF HUMAN COMPLEMENT CONTROL FACTOR AND ITS USE 失效

    公开(公告)号：JP2000002703A

    公开(公告)日：2000-01-07

    申请号：JP16828598

    申请日：1998-06-16

    Applicant: FUSO PHARMACEUTICAL IND

    Inventor： UEMURA HIDETOSHI ,  KISHI YUICHIRO ,  KUNITO KAZUYA ,  HIROOKA YUMI

    IPC: G01N33/50 ,  A61K9/16 ,  A61K39/395 ,  C07K16/18 ,  C12N5/10 ,  C12P21/08 ,  G01N33/53 ,  G01N33/543

    Abstract: PROBLEM TO BE SOLVED: To judge the diagnosis and critical degree of renal disease by bringing a second antibody having a labeled molecule connected thereto into contact with a biological sample and a subject having a first antibody brought into contact with the surface of a solid granule, and detecting the labeled molecule connected to a complement control factor. SOLUTION: With respect to urine and serum of a normal person and a renal disease patient, MCP quantity (membrane cofactor protein) is measured. A magnetic bead having a monoclonal antibody 177, a subject and a POD labeled monoclonal antibody M160 are reacted to focus and fix the bead by the magnet, and the supernatant is disposed. After washing, a substrate solution is added to further react them, and the bead is focused and fixed by the magnet, and the supernatant is collected to measure the absorbance. The serum MCP value is measured by use of the monoclonal antibody M160 and also by use of the POD labeled monoclonal antibody M160 as the detecting antibody. As a result of the measurement, the MCP values in urine and serum are distributed in high level in the renal disease patient, compared with the normal person, and also high in a more critical patient.

    DETECTION OF NUCLEIC ACID
    37.
    发明专利
    DETECTION OF NUCLEIC ACID 失效

    公开(公告)号：JPH0699A

    公开(公告)日：1994-01-11

    申请号：JP15934992

    申请日：1992-06-18

    Applicant: FUSO PHARMACEUTICAL IND

    Inventor： MATSUHISA AKIO ,  SHIBA KIYOTAKA ,  MIKAWA GIICHI ,  KISHI YUICHIRO

    IPC: C12Q1/68 ,  G01N27/447 ,  G01N33/50 ,  G01N33/58

    Abstract: PURPOSE:To provide a method for detecting nucleic acid which is easy, safe, reliable and simple. CONSTITUTION:A solid carrier suspected to attach or contain nucleic acid is brought into contact with a polyamine to which a label (or its precursor) capable of giving measurable signals is bound, forming a composite made up of the nucleic acid and the polyamine. In case the precursor is used, it is transformed into the label. Before and after the transformation, the residual polyamine not forming the above composite is eliminated and then the label is probed, thus detecting the nucleic acid.

    EVALUATION METHOD FOR MAN'S SPERM FERTILITY
    38.
    发明专利
    EVALUATION METHOD FOR MAN'S SPERM FERTILITY 失效

    公开(公告)号：JPH10185919A

    公开(公告)日：1998-07-14

    申请号：JP35072396

    申请日：1996-12-27

    Applicant: FUSO PHARMACEUTICAL IND

    Inventor： OHASHI KAZUTOMO ,  SAJI FUMITAKA ,  NAKAZAWA TERUYOSHI ,  SHINODA SANJI ,  YAMADA MORIYUKI ,  KISHI YUICHIRO

    IPC: G01N33/53 ,  G01N33/577

    Abstract: PROBLEM TO BE SOLVED: To provide a method capable evaluating a fertility easily and surely, even for a sperm sample of a low motional sperm concentration. SOLUTION: On a plate with wells each of a magnitude to be put within a visual field when it is observed with a microscope of a magnification of 100 times, a sperm sample and a monoclonal antibody MH61/beads are used and cultured by comparatively smaller numbers and in a ratio corresponding to about one tenth or more of the number of the sperms, and the united condition of the sperms and the heads are observed by observing the cultured substance with a microscope, and the fertility of the man's sperms evaluated by the observation result.

    CULTURE MEDIUM COMPOSITION FOR EXTERNAL FERTILIZATION
    39.
    发明专利
    CULTURE MEDIUM COMPOSITION FOR EXTERNAL FERTILIZATION 失效

    公开(公告)号：JPH0970240A

    公开(公告)日：1997-03-18

    申请号：JP22633395

    申请日：1995-09-04

    Applicant: FUSO PHARMACEUTICAL IND

    Inventor： NAKAZAWA TERUYOSHI ,  ARAKI HIROMASA ,  KISHI YUICHIRO ,  SHINODA YOSHIHARU ,  YAMADA MORIYUKI ,  OHASHI KAZUTOMO

    IPC: A01K67/02 ,  A01K67/027 ,  C12N5/02 ,  C12N5/073 ,  C12N5/06

    Abstract: PROBLEM TO BE SOLVED: To obtain a culture medium composition for external fertilization, containing specific amino acids (derivatives), capable of promoting the growth of an early embryo, excellent in improvement in stabilization of quality and suitable for culturing the early embryo, pretreatment, etc., of ova and sperms. SOLUTION: This culture medium composition contains amino acids of L- phenylalanine, L-tryptophan, L-lysine, L-threonine, L-valine, L-methionine, L-(iso) leucine, L-proline, glycine, L-alanine, L-tyrosine, L-histidine, L-arginine, L-taurine, L-aspartic acid, L-serine, L-asparagine, L-glutamine (L-glutamic acid) and L- cystine (with the proviso that a part of the L-cystine may be substituted with L-cysteine) or their derivatives in a free form or the form of salts thereof capable of producing the amino acids by hydrolysis. Furthermore, e.g. the concentrations of the L-phenylalanine, L-valine and L-aspartic acid are respectively preferably 0.69-13.8, 1.66-33.1 and 0.09-1.71(mg/l).

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