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    PAPER-BASED MICROFLUIDIC SYSTEMS
    33.
    发明专利
    PAPER-BASED MICROFLUIDIC SYSTEMS 未知

    公开(公告)号：CA2719800A1

    公开(公告)日：2009-10-01

    申请号：CA2719800

    申请日：2009-03-27

    Applicant: HARVARD COLLEGE

    Inventor： SIEGEL ADAM C ,  PHILLIPS SCOTT T ,  DICKEY MICHAEL D ,  ROZKIEWICZ DOROTA ,  WILEY BENJAMIN ,  WHITESIDES GEORGE M ,  MARTINEZ ANDRES W

    IPC: G01N35/00 ,  G01N27/26 ,  G01N33/48

    Abstract: The invention features an assay device, a microfluidic device, and a method of detecting the presence of high electrolyte concentration in a fluid sample. The assay device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier defining a boundary of an assay region and a boundary of a main channel region, the main channel region fluidically connected to the assay region; and a strip of conductive material disposed on the porous, hydrophilic substrate. The microfluidic device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier, the barrier permeating the thickness of the porous, hydrophilic substrate and defining within the porous, hydrophilic substrate a boundary of an open-ended channel having first and second lateral walls; and an electrically conductive pathway disposed on the porous, hydrophilic substrate, the electrically conductive pathway comprising (i) a strip of conductive material forming an open circuit in the absence of an electrically conductive material bridging the first and second lateral walls; and (ii) a battery, an electrically-responsive indicator, and a resistor electrically connected to the strip of conductive material.

    Surfaces that resist the adsorption of biological species
    36.
    发明专利
    Surfaces that resist the adsorption of biological species 未知

    公开(公告)号：AU2001275957B2

    公开(公告)日：2007-01-11

    申请号：AU2001275957

    申请日：2001-07-17

    Applicant: HARVARD COLLEGE

    Inventor： OSTUNI EMANUELE ,  WHITESIDES GEORGE M ,  LIANG MICHAEL N ,  YAN LIN ,  CHAPMAN ROBERT G

    IPC: A61F2/28 ,  A61L15/42 ,  A61L27/34 ,  A61L27/50 ,  A61L31/10 ,  B32B27/06 ,  C08J7/12

    Abstract: The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i.e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

    METHOD OF FORMING ARTICLES AND PATTERNING SURFACES VIA CAPILLARY MICROMOLDING
    38.
    发明专利
    METHOD OF FORMING ARTICLES AND PATTERNING SURFACES VIA CAPILLARY MICROMOLDING 未知

    公开(公告)号：CA2248576C

    公开(公告)日：2006-01-24

    申请号：CA2248576

    申请日：1997-03-14

    Applicant: HARVARD COLLEGE

    Inventor： KIM ENOCH ,  WHITESIDES GEORGE M ,  JACKMAN REBECCA JANE ,  XIA YOUNAN ,  MRKSICH MILAN

    IPC: B29C39/24 ,  A61K9/51 ,  A61K47/48 ,  B01J19/00 ,  B29C31/04 ,  B29C33/42 ,  B29C37/00 ,  B29C67/24 ,  B81C1/00 ,  C40B60/14 ,  G01N33/543 ,  H05K3/00 ,  H05K3/06

    Abstract: Techniques for patterning chemically or biochemically active agents on a substrate surface involve providing a micromold having a contoured surface including indentations defining a pattern and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure on the surface. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be employed to form patterned polymeric articles, inorganic salts and ceramics, etc. at the surface. The articles, according to one aspect, are formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter. Smaller dimensions can be achieved. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. The invention provides for inexpensive and simple synthesis of a combinatorial chemical or biochemical library.

    METHOD OF SELF-ASSEMBLY AND SELF-ASSEMBLED STRUCTURES
    39.
    发明专利
    METHOD OF SELF-ASSEMBLY AND SELF-ASSEMBLED STRUCTURES 未知

    公开(公告)号：AU2003230860A1

    公开(公告)日：2003-10-27

    申请号：AU2003230860

    申请日：2003-04-10

    Applicant: HARVARD COLLEGE

    Inventor： JACOBS HEIKO O ,  TAO ANDREA R ,  SCHWARTZ ALEXANDER ,  GRACIAS DAVID H ,  WHITESIDES GEORGE M

    IPC: H01L21/60 ,  H01L21/98 ,  H01L23/538 ,  H05K1/18 ,  H05K3/34

    Abstract: The present invention is directed to self-assembly of structures, and, in particular, to self-assembly by action of a liquid patterned onto a substrate. In one embodiment, the present invention is directed to method of self-assembling a plurality of structures. The method includes patterning a first liquid onto a first substrate, and, while at least a portion of the first liquid remains in liquid form, self-assembling at least a portion of the plurality of structures onto the substrate by action of the first liquid and according to the pattern of the first liquid. In another embodiment, the present invention is directed to a display. The display includes a first substrate and a first plurality of electrical connectors being in electrical connection with one another. The display further includes a second substrate, at least some of the second plurality of electrical connectors being in electrical connection with one another. The display further includes a plurality of display elements each electrically connected to at least one of the first plurality of electrical connectors and the second plurality of connectors. In this embodiment, each of the plurality of display elements has an average diameter of less than 1 millimeter.

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