-
公开(公告)号:JPH08319263A
公开(公告)日:1996-12-03
申请号:JP12482595
申请日:1995-05-24
Applicant: KAO CORP
Inventor: MURAYAMA KOICHI , HOSHINO TADAHIDE , KUSUOKU HIROSHI , NAGAI MINORU , SUGINO KIYOKO
IPC: C07D303/18 , A61K8/00 , A61K8/30 , A61K8/41 , A61K8/42 , A61K8/68 , A61K31/16 , A61K31/195 , A61Q5/00 , A61Q19/00 , C07C217/28 , C07C231/02 , C07C231/12 , C07C233/05 , C07C233/18 , A61K7/00 , A61K7/06
Abstract: PURPOSE: To obtain an amide derivative, represented by a specific formula, having excellent water holding and water cutoff abilities and further excellent improving effects on the water holding ability of a horny layer and useful as a dermal preparation for external use and a hair cosmetic, etc. CONSTITUTION: A amide derivative of formula I [R and R are each a 1-40C (hydroxylated)hydrocarbon; R is a 1-6C alkylene or a single bond; R is H, a 1-12C alkoxy or 2,3-dihydroxypropyloxy, with the proviso that R is H when R is the single bond]. Furthermore, the derivative is preferably obtained by reacting, e.g. a glycidyl ether of formula II with an amine of formula III (R is H or a 1-12C alkoxy, with the proviso that R is H when R is the single bond) (at ambient temperature to 150 deg.C), then reacting the resultant amino-alcohol derivative with methyl ester of a fatty acid, etc., in the presence of a basic catalyst (at ambient temperature to 150 deg.C under atmospheric pressure to 0.01mmHg), further reacting the prepared amide derivative with an epoxide such as epichlorohydrin in the presence of potassium hydroxide, etc., (at ambient temperature to 150 deg.C) and hydrating the resultant amide derivative of formula IV under basic conditions, etc., at ambient temperature to 300 deg.C.
-
公开(公告)号:JP2007137786A
公开(公告)日:2007-06-07
申请号:JP2005330504
申请日:2005-11-15
Inventor: ISHITA MIO , SUGAI YOSHIYA , SAITO HIROAKI , NAGAI MINORU , TANAMACHI HIROTO , USUNAMI FUMIKO
IPC: A61K8/42 , A61Q5/12 , C07C233/18 , C07C233/36
Abstract: PROBLEM TO BE SOLVED: To provide a substance for recovering elasticity of the hair damaged by daily physical and chemical stimulation and improving physical properties of the hair.
SOLUTION: The hair elasticity-improving agent comprises a monoamide derivative represented by general formula (1) (wherein R
1 and R
2 are each same or different and they are each a 4-14C hydrocarbon group; R
3 is a hydrogen atom or a 1-12C alkyl group which may be substituted with a group selected from a 1-6C alkoxy group, a 1-6C hydroxyalkoxy group and a 1-6C alkylamino group) as an active ingredient.
COPYRIGHT: (C)2007,JPO&INPITAbstract translation: 要解决的问题:提供用于回收由日常物理和化学刺激损伤的头发的弹性并改善头发的物理性质的物质。 解决方案:毛发弹性改进剂包括由通式(1)表示的单酰胺衍生物(其中R
1 SP>和R 2 SP>各自相同或不同,它们 各自为4-14C烃基; R 3为氢原子或可被选自1-6C烷氧基,1-6C羟基烷氧基中的基团取代的1-12C烷基 基团和1-6C烷基氨基)作为活性成分。 版权所有(C)2007,JPO&INPIT -
公开(公告)号:JP2007008873A
公开(公告)日:2007-01-18
申请号:JP2005192338
申请日:2005-06-30
Inventor: NAGAI MINORU , SAITO HIROAKI , ISHITA MIO , SUGAI YOSHIYA , TANAMACHI HIROTO , USUNAMI FUMIKO
Abstract: PROBLEM TO BE SOLVED: To ameliorate the resilience of the hair damaged by daily physical and chemical attacks.
SOLUTION: A dimer acid amide obtained by reaction of a dimer acid with ammonia or an amine is to be used as a hair resilience ameliorator. Besides, using (A) such a dimer acid amide together with (B) a cationic surfactant and (C) an oil, and optionally (D) an aromatic alcohol and/or cationic polymer, hair cosmetics including rinses, conditioners and treatments are provided.
COPYRIGHT: (C)2007,JPO&INPITAbstract translation: 要解决的问题:改善日常物理和化学攻击损坏的头发的弹性。 解决方案:将二聚酸与氨或胺反应获得的二聚酸酰胺用作毛发弹性改良剂。 此外,使用(A)这样的二聚酸酰胺与(B)阳离子表面活性剂和(C)油,和任选地(D)芳族醇和/或阳离子聚合物一起提供包括漂洗剂,调理剂和处理剂的头发化妆品 。 版权所有(C)2007,JPO&INPIT
-
公开(公告)号:JP2005281293A
公开(公告)日:2005-10-13
申请号:JP2004370652
申请日:2004-12-22
Inventor: FUJIMURA TSUTOMU , ITO NORIKO , NAGAI MINORU , ONO TOSHIYA , YAMAMURO AKIRA , TAKEMA YOSHINORI
Abstract: PROBLEM TO BE SOLVED: To prepare a cosmetic having excellent effects on suppression of formation of wrinkles and effects on elimination of the wrinkles and further a good feeling of use.
SOLUTION: A wrinkle ameliorating agent and an anti-aging cosmetic comprise a guanidine derivative represented by formula (1) (in formula (1), the lower formula denotes a heterocyclic group selected from azetidine, pyrrolidine, piperidine, piperazine and morpholine; and R
1 and R
2 are each the same or different and denote each hydrogen atom, an alkyl group, hydroxy group, a hydroxyalkyl group, carboxy group, a carboxyalkyl group or an amidino group) or its salt.
COPYRIGHT: (C)2006,JPO&NCIPIAbstract translation: 要解决的问题:为了制备对抑制皱纹形成和对消除皱纹的效果具有优异效果的化妆品,并且进一步具有良好的使用感。 解决方案:皱纹改良剂和抗衰老化妆品包含由式(1)表示的胍衍生物(在式(1)中,下式表示选自氮杂环丁烷,吡咯烷,哌啶,哌嗪和吗啉的杂环基 R 1和R 2各自相同或不同,表示各个氢原子,烷基,羟基,羟基烷基,羧基,羧基烷基 或脒基)或其盐。 版权所有(C)2006,JPO&NCIPI
-
公开(公告)号:JPH1135546A
公开(公告)日:1999-02-09
申请号:JP19549297
申请日:1997-07-22
Applicant: KAO CORP
Inventor: NAGAI MINORU , HASHIZUME KOJIRO , OISHI SUSUMU , ONO TOSHIYA , YAMAMURO AKIRA , FUJIKURA YOSHIAKI
Abstract: PROBLEM TO BE SOLVED: To obtain a new compound having a good touch of use, capable of imparting flexibility to hair also in a neutral region after dried, and useful for hair cosmetics. SOLUTION: A guanidine derivative of the formula (R is a 2-6C alkylene; R is a branched 12-24C alkyl, an alkenyl) or its salt, e.g. 3-(2 -heptylundecyl) oxypropylguanidine hydrochloride. The compound of the formula is obtained by reacting an amine compound such as 3 -(2-heptylundecyl) oxypropylamine with a guanidyl group-introducing reagent such as cyanamide at 0-200 deg.C for 1-72 hr with stirring. One or more kinds of compounds among the compound of the formula may preferably be added to a hair cosmetic such as pre-shampoo, shampoo or hair rinse in an amount of 0.01-20 wt.%.
-
公开(公告)号:JPH09169614A
公开(公告)日:1997-06-30
申请号:JP33524995
申请日:1995-12-22
Applicant: KAO CORP
Inventor: NOJIMA KAZUHIKO , YAGO YUKO , HOSHINO TADAHIDE , MURAYAMA KOICHI , KUSUOKU HIROSHI , NAGAI MINORU
IPC: A61K8/30 , A61K8/00 , A61K8/18 , A61K8/42 , A61K8/68 , A61K8/72 , A61K8/89 , A61K8/92 , A61K8/96 , A61Q1/00 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q1/12 , C07C233/18 , C07C233/20 , C08L83/12 , A61K7/00 , A61K7/02 , A61K7/032
Abstract: PROBLEM TO BE SOLVED: To prepare an oil-based solid cosmetic, capable of providing sufficient moistness to the skin, raising the water holding ability, preventing and reducing the skin roughening, drying, etc., and good in makeup durability by combining ceramides with a specific silicone derivative and other three substances. SOLUTION: This oil-based solid cosmetic is obtained by combining and blending a compound (0.001-50wt.%) selected from a ceramide of formula I (R and R are each a hydrocarbon) or a substance having a ceramidelike structure of formula II [R is a hydrocarbon; R is a hydrocarbon; X and Y are each H or OH; (k) is 0 or 1; (m) is 0-4; (1) and (n) are each 0-3] and formula III [R and R are each a (hydroxylated)hydrocarbon; R' is an alkylene, etc.; R is H, an alkoxy, etc.] with a polyoxyalkylene-modified organopolysiloxane (0.1-50wt.%) of formula IV [R , R and R are each H, an alkyl, etc.; R to R , R and R are each H, phenyl, etc.; (r) and (s) are each a number providing 1-50wt.% polyoxyalkylene], a (semi)solid fat (0.1-50wt.%), a liquid oil (1-80wt.%) and a pigment (0.1-80wt.%).
-
公开(公告)号:JPH0995477A
公开(公告)日:1997-04-08
申请号:JP18891395
申请日:1995-07-25
Applicant: KAO CORP
Inventor: NAGAI MINORU , ONO TOSHIYA , KAWADA YUZO , YAMAZAKI SEIJI , YAMAMURO AKIRA , TSUCHIYA MAYUMI
IPC: A61K8/30 , A61K8/00 , A61K8/43 , A61Q5/00 , A61Q19/00 , C07C277/02 , C07C277/08 , C07C279/08 , A61K7/00 , A61K7/48
Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound having humidity-retaining action and keratin-softening action and useful as a blend component for skin cosmetics and hair cosmetics, and further, a synthetic intermediate for agrochemicals, medicined and dyes. SOLUTION: This guaidine derivative is represented by formula I [A and B are each a 2-8C alkylene; D is a direct bond, CO or a 1-6C alkylene; E is H, a lower alkyl, an aralkyl or an aryl; (m) is 1-6; (n) is 0-6; R is H, a lower alkyl or (AO)m -(BO)n -D-E, with the proviso that, when A is a straight-chain alkylene and (m) is 1 and (n) is 0, R is not H and, when R is H, methyl or hydroxyethyl, (AO)m -(BO)n -D-E is not hydroxyethyl and, when R is H, (AO)m -(BO)n -D-E is not a lower alkoxyethyl] or its acid addition salt. The derivative is obtained by reacting an amine of formula II with a guanidylating reagent. The compound of formula I includes e.g. 2-(2-hydroxyethoxy)ethyl-guanidine.
-
公开(公告)号:JPH08319233A
公开(公告)日:1996-12-03
申请号:JP12482495
申请日:1995-05-24
Applicant: KAO CORP
Inventor: MURAYAMA KOICHI , HOSHINO TADAHIDE , KUSUOKU HIROSHI , NAGAI MINORU , SUGINO KIYOKO
IPC: A61K8/00 , A61K8/04 , A61K8/30 , A61K8/42 , A61K31/16 , A61P17/00 , A61P43/00 , A61Q5/00 , A61Q7/00 , A61Q19/00 , A61Q19/08 , A61K7/00 , A61K7/06 , A61K7/48
Abstract: PURPOSE: To prepare a dermal preparation for external use excellent in improving skin roughness and a hair cosmetic of improved hair feeling by increasing keratin moisture retention. CONSTITUTION: This preparation contains an amido derivative of the formula (R and R are each a 1-40C hydrocarbon which can be hydroxylated; R is a 3-6C alkylene; R is a 1-12C alkoxy). The blending amounts are 0.001-50wt.% in emulsion type dermal preparation for external use, 1-50wt.% in oil type dermal preparation for external use, 0.001-5wt.% in shampoo as hair cosmetic, 0.1-20wt.% in rinse, hair treatment, conditioner and 0.01-5wt.% in hair liquid and hair tonic. The dermal preparation for external use is effective for preventing and curing skin roughness and skin aging. The hair cosmetic is excellent in hair and scalp protection with retention while improves hair feeling.
-
公开(公告)号:JPH06135914A
公开(公告)日:1994-05-17
申请号:JP29138792
申请日:1992-10-29
Applicant: KAO CORP
Inventor: NAGAI MINORU , OHASHI YUKIHIRO , TSUKAHARA ITSURO , SHIBATA KEIJI , KAWAMATA AKIRA
IPC: B01J23/02 , B01J31/12 , C07B61/00 , C07C231/02 , C07C233/18 , C07C233/20 , C07C235/08
Abstract: PURPOSE:To produce an amide derivative in high purity and yield by highly selectively amidating an amino-alcohol. CONSTITUTION:An amino-alcohol of formula 2 (R is straight-chain or branched chain hydrocarbon group or H; R is straight-chain or branched chain bivalent hydrocarbon group) is made to react with a carboxylic acid ester of formula 3 (R is straight-chain or branched chain saturated or unsaturated hydrocarbon which may have OH; R is lower hydrocarbon group) or a lactone of formula 4 (R is straight-chain or branched chain saturated or unsaturated bivalent hydrocarbon group which may have OH) in the presence of a basic catalyst, preferably at 60-150 deg.C temperature. The resultant reactional product after completing the reaction is then cooled and kept at a temperature wherein only an amide derivative that is the objective compound deposits in a solid state for >=1hr. Thereby, the amide derivative of formula 1 or 1' is obtained. The amino-alcohol of formula 2 containing remaining compounds of formula 5 or 5' which are by-products can efficiently be made to react by removing the compound of formula 1 or 1' from the reactional equilibrium system.
-
公开(公告)号:JP2005272363A
公开(公告)日:2005-10-06
申请号:JP2004088685
申请日:2004-03-25
Inventor: NOJIRI MASAYOSHI , NAGAI MINORU
IPC: A61K8/00 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/49 , A61K8/86 , A61K8/89 , A61K8/891 , A61K8/92 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/12 , C08L83/04 , A61K7/06 , A61K7/075 , A61K7/08 , A61K7/11
CPC classification number: A61K8/34 , A61K8/347 , A61K8/362 , A61K8/4913 , A61K8/4973 , A61K8/86 , A61Q5/06 , A61Q5/12
Abstract: PROBLEM TO BE SOLVED: To provide a hair cosmetic ameliorating the hair intrinsically, improving gloss and arrangeable properties of the hair, and providing excellent touch feeling.
SOLUTION: The hair cosmetic contains (A) an organic 5-40C polybasic carboxylic acid having 4-10 carboxylic groups or a salt thereof, and (B) an organic solvent selected from the group consisting of an aromatic alcohol, an N-alkylpyrrolidone, an alkylene carbonate, a polypropylene glycol, a lactone and a cyclic ketone, and having (-2)-3 ClogP, and provides a solution diluted to 20 times by weight with water and having pH 2-5 at 25°C.
COPYRIGHT: (C)2006,JPO&NCIPIAbstract translation: 要解决的问题:提供一种改善头发本发明的毛发化妆品,提高头发的光泽和布置性能,并提供优异的触感。 解决方案:毛发化妆品含有(A)具有4-10个羧基的有机5-40C多元羧酸或其盐,和(B)选自芳族醇,N - 烷基吡咯烷酮,碳酸亚烷基酯,聚丙二醇,内酯和环酮,并且具有(-2)-3ClogP,并且提供用水稀释至20重量%的溶液,并且在25℃下具有pH 2-5 。 版权所有(C)2006,JPO&NCIPI
-
-
-
-
-
-
-
-
-