公开(公告)号：JP2001294522A

公开(公告)日：2001-10-23

申请号：JP2000114128

申请日：2000-04-14

Applicant: KAO CORP

Inventor： IWAI YASUSHI ,  NISHISAKA TAKAHIRO ,  NAKATANI ARISA ,  KAWADA YUZO ,  YAMAZAKI SEIJI

IPC: A61K8/00 ,  A61K8/02 ,  A61K8/19 ,  A61K8/72 ,  A61K8/87 ,  A61K8/92 ,  A61K8/96 ,  A61Q19/00 ,  A61Q90/00 ,  A61K7/48 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain a sebum care cosmetic capable of remarkably suppressing the stickiness due to the sebum, maintaining a dry feeling and improving the skin quality. SOLUTION: This solid sebum care cosmetic comprises (A) 30-70 wt.% of a powder and (B) 20-70 wt.% of an oily ingredient and has 0.25-0.7 coefficient of dynamic friction on a coated surface in which the top surface of a synthetic leather made of a polyurethane is coated with the composition.

公开(公告)号：JPH11106216A

公开(公告)日：1999-04-20

申请号：JP26854397

申请日：1997-10-01

Applicant: KAO CORP

Inventor： KAWADA YUZO ,  UCHIDA HIROKO ,  YAMAZAKI SEIJI ,  INOMATA YUKIO ,  TAGUCHI KAZUO ,  HORIBATA TATSUYA ,  MIYATAKE YOSHIKAZU

IPC: A61K8/19 ,  A61K8/00 ,  A61K8/27 ,  A61K8/34 ,  A61K8/92 ,  A61Q17/04 ,  C01G9/02 ,  A61K7/00 ,  A61K7/42

Abstract: PROBLEM TO BE SOLVED: To obtain the subject highly transparent dispersion high in ultraviolet- protective ability by dispersing a specific proportion of zinc oxide particles, in the form of primary particles, in a specific dispersion medium so as to bring the visible ray transmittance of the resulting dispersion to a specific value or greater. SOLUTION: This zinc oxide dispersion is such one as to contain zinc oxide microparticles at 5-50 wt.% which is dispersed in the form of primary particles, being >=30% in visible ray transmittance under a thickness of 1 cm. The dispersion medium to be used is one or more kinds of substance selected from cosmetic oils, silicone oils, polyols, ethanol and water. The value of the ultraviolet- protective ability A per 1,000 nm thick (given by a specified formula) of a coating film obtained by casting this zinc oxide dispersion on a silica glass is >=3. This dispersion is obtained, for example, by the following process: a zinc salt is dispersed or dissolved in ethanol followed by addition of an alkali to form a zinc oxide sol, and a hydrophobic acid is then adsorbed to the sol into a lipophilic sol, which, in turn, is treated with a polymer or surfactant to effect solubilization, and the resultant sol is dispersed in a dispersion medium.

公开(公告)号：JPH09263511A

公开(公告)日：1997-10-07

申请号：JP26626796

申请日：1996-10-07

Applicant: KAO CORP

Inventor： FUJIMURA TSUTOMU ,  ITO NORIKO ,  TAKEMA YOSHINORI ,  YAMAZAKI SEIJI ,  KAWADA YUZO ,  YAMAMURO AKIRA ,  NAGAI MINORU ,  ONO TOSHIYA

IPC: C07H5/04 ,  A61K8/00 ,  A61K8/30 ,  A61K8/36 ,  A61K8/362 ,  A61K8/37 ,  A61K8/41 ,  A61K8/42 ,  A61K8/43 ,  A61K8/49 ,  A61K8/60 ,  A61K8/68 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain the subject preparation capable of persisting an excellent flexibility-imparting effect to horny layers and an excellent skin wrinkle- improving effect for a long time and useful for skin-softening cosmetics, antiaging cosmetics, etc. SOLUTION: This preparation for external uses for skins contains a guanidine derivative of formula I (R is a hydrocarbon group, an aromatic ring group, an aralkyl group, etc.; R is H, a hydrocarbon group) or its acid adduct, a synthetic sphingosine derivative of formula II (R is a 4-40C hydrocarbon group; R , R , R , R , R are each H, a 1-10C hydrocarbon; X, Y are each H, a 1-6C alkyl which may have an oxygen atom), and an organic acid such as a dicarboxylic acid or its ester. The guanidine derivative, the synthetic sphingosine derivative, and the organic acid or its ester are preferably compounded in amounts of 0.001-50wt.%, 0.0001-10wt.% and 0.001-30wt.%, respectively, in the preparation.

公开(公告)号：JP2007001905A

公开(公告)日：2007-01-11

申请号：JP2005182608

申请日：2005-06-22

Applicant: KAO CORP

Inventor： NAGASAWA MAKI ,  KAWADA YUZO

IPC: A61K8/00 ,  A61K8/30 ,  A61Q19/00

Abstract: PROBLEM TO BE SOLVED: To provide a cosmetic having excellent wrinkle ameliorating effects. SOLUTION: The cosmetic comprises the following ingredients (A) and (B): (A)0.00001-5 mass% of a fructosyl dipeptide represented by general formula Fru-A-B-R (1) (wherein, Fru represents a fructosyl residue; A and B represent each an amino acid residue; and R represents a hydroxy group in a C-terminal carboxy group of the amino acid residue or a methyl esterified group thereof) or a salt thereof and (B) 0.0001-50 mass% of a guanidine derivative or a salt thereof. COPYRIGHT: (C)2007,JPO&INPIT

公开(公告)号：JP2005097250A

公开(公告)日：2005-04-14

申请号：JP2004190728

申请日：2004-06-29

Applicant: Kao Corp ,  花王株式会社

Inventor： AMANO SHINYA ,  SANO TOMOHIKO ,  KAWADA YUZO ,  KAWADA TAKASHI

IPC: A61K8/00 ,  A61K8/26 ,  A61K8/55 ,  A61K8/58 ,  A61K31/66 ,  A61K31/661 ,  A61P17/16 ,  A61Q19/00 ,  A61Q19/08 ,  C07F9/06 ,  C07F9/08 ,  C07F9/09 ,  A61K7/00 ,  A61K7/48

CPC classification number: A61K8/556 ,  A61K8/26 ,  A61Q19/00 ,  A61Q19/08 ,  C07F9/091

Abstract: PROBLEM TO BE SOLVED: To provide a compound efficiently acting on the pores, etc.
SOLUTION: The invention provides a phosphorylated glyceryl ether aluminum salt expressed by general formula (1) and a skin lotion containing the salt. In the formula, R
1 is an 8-23C alkyl or alkenyl; R
2 is a hydrogen atom, phosphate residue or CH
2 CH(OR
2 )CH
2 OR
1 (R
1 and R
2 are the same as those defined above provided that the repeatedly bonding number is ≤4 when R
2 is CH
2 CH(OR
2 )CH
2 OR
1 ); X
1 is a hydrogen atom or phosphate residue; at least one of X
1 and R
2 is a phosphate residue; Y is an alkali metal atom or an alkaline earth metal atom; m is 0.3-1; and n is 0-1.
COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：提供有效作用于孔等的化合物。解决方案：本发明提供由通式（1）表示的磷酸化甘油醚铝盐和含有该盐的皮肤洗剂。 在该式中，R 1 SP 1是8-23C烷基或链烯基; R 2 是氢原子，磷酸酯残基或CH 2 CH（OR SP＆gt; 2＆lt; SP＆gt;）CH 2 > 1 （R 1 和R 2 与上述定义相同，条件是当R 2时，反复接合数≤4， SP>是CH 2 CH（OR 2 ）CH 2 OR 1 ）; X 1 是氢原子或磷酸酯残基; X 1 和R 2 中的至少一个是磷酸酯残基; Y是碱金属原子或碱土金属原子; m为0.3-1; n为0-1。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2005023005A

公开(公告)日：2005-01-27

申请号：JP2003188983

申请日：2003-06-30

Applicant: Kao Corp ,  花王株式会社

Inventor： SUZUKI KEIKO ,  SANO TOMOHIKO ,  KAWADA YUZO ,  NAKAJIMA ATSUSHI ,  NAGASAWA MAKI

IPC: A61K8/49 ,  A61K8/00 ,  A61K8/04 ,  A61K8/96 ,  A61K8/97 ,  A61Q19/00 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To provide an excellent composition which effectively improves the wrinkles of the skins.
SOLUTION: This wrinkle-improving composition contains the following ingredients (A) and (B): (A) a guanidine derivative represented by the general formula (1) (the formura (1a) represents a heterocyclic group selected from azetidine, pyrrolidine, piperidine, piperazine, and morpholine; R
1 and R
2 are each identically or differentially H, an alkyl, hydroxyl, a hydroxyalkyl, carboxyl, a carboxyalkyl or amidino) or its salt, and (B) a plant extract having an actin-myosin system-activating action.
COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：提供有效改善皮肤皱纹的优异组合物。 解决方案：该皱纹改良组合物含有下列成分（A）和（B）：（A）由通式（1）表示的胍衍生物（甲醛（1a）表示选自氮杂环丁烷， 吡咯烷，哌啶，哌嗪和吗啉; R 1和R 2各自相同或不同，H，烷基，羟基，羟烷基，羧基，羧基烷基或脒基） 或其盐，和（B）具有肌动蛋白 - 肌球蛋白系统激活作用的植物提取物。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2002255742A

公开(公告)日：2002-09-11

申请号：JP2001053843

申请日：2001-02-28

Applicant: KAO CORP

Inventor： KUME TAKUSHI ,  KAWADA YUZO ,  MOCHIZAI YASUHIRO ,  SANO TOMOHIKO

IPC: A61K8/02 ,  A61K8/00 ,  A61K8/72 ,  A61Q19/00 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To prepare a pack cosmetic capable of suitably absorbing sebum, excellent in improving and preventing effects on fatty feeling of sebum and smeared makeup, having good usability and capable of imparting actual feeling of surely removing effect on sebum to users. SOLUTION: This pack cosmetic comprises (A) oil-absorbing powder having >=1 mL/g absorption amount of squalane and (B) a water-soluble pigment.

公开(公告)号：JPH09194322A

公开(公告)日：1997-07-29

申请号：JP851196

申请日：1996-01-22

Applicant: KAO CORP

Inventor： NONOMURA MASAMI ,  KAWADA YUZO ,  HOSOKAWA MASARU ,  SUZUKI KEIKO ,  FUJI AKIRA ,  KATOU YUURI ,  NAGASAWA MAKI

IPC: A61K8/19 ,  A61K8/00 ,  A61K8/25 ,  A61K8/27 ,  A61K8/29 ,  A61K8/72 ,  A61K8/73 ,  A61K8/96 ,  A61K8/97 ,  A61K36/18 ,  A61P17/00 ,  A61Q19/00 ,  C01B33/14 ,  C01G23/04 ,  C08B37/00 ,  A61K7/00 ,  A61K7/48 ,  A61K35/78

Abstract: PROBLEM TO BE SOLVED: To obtain a preparation for external use for the skin excellent in moisture retaining effect, capable of strongly adhering to the skin and excellent in water resistance and durable effects by combining an acidic heteropolysaccharide with a sol of a specific metal. SOLUTION: In this preparation for external use for the skin, both (A) an acidic heteropolysaccharide and (B) sol of a superfine metal oxide are used. As the acidic heteropolysaccharide, the one derived from a callus of a plant belonging to the genus Polianthes L. or from a callus of Polianthes tuberosa L. is preferable. As the sol of the superfine metal oxide, an aqueous sol in which the superfine metal oxide particles having 0.005-0.1μm average size are dispersed is preferable. The aqueous sol preferably contains 5-30wt.% dispersed superfine metal oxide particles. As the metal oxide, titanium oxide or silicon oxide is preferable. The weight ratio of the component A to an active concentration B' of the metal oxide in the sol is preferably A/B' of (0.2/0.001)-(0.2/4). This preparation for external use for the skin is good in feeling in use.

公开(公告)号：JPH0995477A

公开(公告)日：1997-04-08

申请号：JP18891395

申请日：1995-07-25

Applicant: KAO CORP

Inventor： NAGAI MINORU ,  ONO TOSHIYA ,  KAWADA YUZO ,  YAMAZAKI SEIJI ,  YAMAMURO AKIRA ,  TSUCHIYA MAYUMI

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/43 ,  A61Q5/00 ,  A61Q19/00 ,  C07C277/02 ,  C07C277/08 ,  C07C279/08 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound having humidity-retaining action and keratin-softening action and useful as a blend component for skin cosmetics and hair cosmetics, and further, a synthetic intermediate for agrochemicals, medicined and dyes. SOLUTION: This guaidine derivative is represented by formula I [A and B are each a 2-8C alkylene; D is a direct bond, CO or a 1-6C alkylene; E is H, a lower alkyl, an aralkyl or an aryl; (m) is 1-6; (n) is 0-6; R is H, a lower alkyl or (AO)m -(BO)n -D-E, with the proviso that, when A is a straight-chain alkylene and (m) is 1 and (n) is 0, R is not H and, when R is H, methyl or hydroxyethyl, (AO)m -(BO)n -D-E is not hydroxyethyl and, when R is H, (AO)m -(BO)n -D-E is not a lower alkoxyethyl] or its acid addition salt. The derivative is obtained by reacting an amine of formula II with a guanidylating reagent. The compound of formula I includes e.g. 2-(2-hydroxyethoxy)ethyl-guanidine.

公开(公告)号：JP2009073777A

公开(公告)日：2009-04-09

申请号：JP2007245159

申请日：2007-09-21

Applicant: Kao Corp ,  花王株式会社

Inventor： TAKAZAWA NOBUO ,  NAGASAWA MAKI ,  KAWADA YUZO ,  FURUKAWA TOMOMI

IPC: A61K8/97 ,  A61Q19/00

Abstract: PROBLEM TO BE SOLVED: To provide a cosmetic capable of effectively ameliorating skin wrinkles and excellent in stability with time.
SOLUTION: The cosmetic contains (A) extract(s) of plant(s) having actin-myosin-based activation effect, wherein the plant(s) is (are) selected from horse chestnut, scutellariae radix, cork tree bark, gardenia, Rehmannia glutinosa, ginger and cranesbill and (B) one or more extracts selected from lemon extract and hydrolysis yeast extract.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 待解决的问题：提供能够有效地改善皮肤皱纹并且随时间稳定性优异的化妆品。 化妆品包含（A）具有肌动蛋白 - 肌球蛋白的活化作用的植物提取物，其中植物选自马蹄，黄芩，软木树皮 ，栀子，地黄，姜和起重机和（B）一种或多种选自柠檬提取物和水解酵母提取物的提取物。 版权所有（C）2009，JPO＆INPIT