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    36.
    发明专利
    未知

    公开(公告)号：FI112377B

    公开(公告)日：2003-11-28

    申请号：FI942794

    申请日：1994-06-13

    Applicant: SQUIBB BRISTOL MYERS CO

    Inventor： HANSON RONALD L ,  PATEL RAMESH N ,  SZARKA LASZLO J

    IPC: C12N1/20 ,  C07D305/14 ,  C12N9/14 ,  C12N9/18 ,  C12P17/02 ,  C12Q1/04 ,  C12R1/01 ,  C12N9/00

    Abstract: An enzymatic hydrolysis method, wherein one or more C-10 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. Also provided is an enzymatic esterification method, wherein one or more C-10 hydroxyl-bearing taxanes are contacted with an acylating agent and an enzyme or microorganism capable of esterifying said hydroxyl groups to form acyloxy groups. Further provided is an enzymatic hydrolysis method, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. The methods are especially useful for the preparation of compounds which may be employed as intermediates in the preparation of taxanes such as taxol.

    Stereoselective reduction of substituted oxo-butanes
    37.
    发明专利
    Stereoselective reduction of substituted oxo-butanes 未知

    公开(公告)号：CZ2003758A3

    公开(公告)日：2003-11-12

    申请号：CZ2003758

    申请日：2001-07-20

    Applicant: SQUIBB BRISTOL MYERS CO

    Inventor： PATEL RAMESH N ,  CHU LINDA

    IPC: C12P13/02 ,  C07D301/26 ,  C07D303/36 ,  C12P13/00 ,  C12R1/01 ,  C12S99/00

    Abstract: The present invention relates to a process for the stereoselective enzymatic reduction of 1-halo-2-oxo-3-(protected)amino-4-substituted-butanes utilizing certain species of Rhodococcus and Brevibacterium. The product 1-halo-2-hydroxy-3-(protected)amino-4-substituted-butanes, which are useful as intermediates in the synthesis of compounds that are inhibitors of ACE, renin and HIV proteases, are obtained in high yield and, particularly, in very high diastereomeric purity. The process is advantageously highly selective for the (3S,2R) enantiomer of the product.

    Pichia pastoris formate dehydrogenase and uses therefor
    39.
    发明专利
    Pichia pastoris formate dehydrogenase and uses therefor 未知

    公开(公告)号：AU2002359721A8

    公开(公告)日：2003-07-09

    申请号：AU2002359721

    申请日：2002-12-16

    Applicant: SQUIBB BRISTOL MYERS CO

    Inventor： GOLDBERG STEVEN L ,  NANDURI VENKATA B ,  CINO PAUL M ,  PATEL RAMESH N ,  JOHNSTON ROBERT M

    IPC: C12N9/02 ,  C12P21/04 ,  C12Q1/26 ,  C12N9/04 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

    Abstract: This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encoding P. pastoris FDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinant P. pastoris FDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind to P. pastoris FDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated P. pastoris FDH nucleic acids, polypeptides, and antibodies, and methods of using P. pastoris FDH in various reactions for industrial or pharmaceutical applications.

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