公开(公告)号：DE60017702D1

公开(公告)日：2005-03-03

申请号：DE60017702

申请日：2000-03-03

Applicant: SYMYX TECHNOLOGIES INC

Inventor： BERGH HOWARD ,  GUAN SHENHENG

IPC: B01F5/06 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  C01B3/40 ,  C07C17/23 ,  C07C45/34 ,  C07C45/35 ,  C07C45/38 ,  C07C45/46 ,  C07C45/50 ,  C07C45/54 ,  C07C45/72 ,  C40B30/08 ,  C40B40/18 ,  G01N30/90 ,  G01N31/10 ,  G01N35/00 ,  G01N35/02

Abstract: A chemical processing microsystem useful for identifying and optimizing materials (e.g., catalysts) that enhance chemical processes or for characterizing and/or optimizing chemical processes is disclosed. The chemical processing microsystem comprises a plurality of microreactors (600) and, in a preferred embodiment, a plurality of microseparators (900) integral with the chemical processing microsystem (10). The microreactors (600) are preferably diffusion-mixed microreactors formed in a plurality of laminae that include a modular, interchangeable candidate-material array (100). The material array (100) comprises a plurality of different candidate materials (e.g., catalysts), preferably arranged at separate, individually addressable portions of a substrate (e.g., wafer). The microseparators (900) are similarly formed in a plurality of laminae that include a modular, interchangeable adsorbent array (700). The adsorbent array (700) comprises one or more adsorbents, preferably arranged at separate, individually addressable portions of a substrate to spatially correspond to the plurality of different candidate materials. Modular microfluidic distribution systems are also disclosed. The chemical processing microsystem can be integrated into a material evaluation system that enables a comprehensive combinatorial material science research program.

公开(公告)号：DE69730883T2

公开(公告)日：2005-01-27

申请号：DE69730883

申请日：1997-10-08

Applicant: SYMYX TECHNOLOGIES INC

Inventor： WEINBERG W HENRY ,  MCFARLAND ERIC W ,  CONG PEIJUN ,  GUAN SHENHENG

IPC: B01J19/00 ,  C07B61/00 ,  C07F15/00 ,  C07F15/04 ,  C08F10/00 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/14 ,  G01H13/00 ,  G01J4/00 ,  G01N3/00 ,  G01N9/00 ,  G01N21/21 ,  G01N21/25 ,  G01N21/64 ,  G01N21/66 ,  G01N29/02 ,  G01N29/036 ,  G01N29/24 ,  G01N29/34 ,  G01N29/42 ,  G01N29/44 ,  G01N33/53 ,  G01N33/543 ,  H01J49/00 ,  H01J49/04 ,  H03H9/19

Abstract: A method of characterizing materials comprising the steps of: providing a substrate; synthesizing an array of materials on said substrate; providing at least one reactant gas wherein said reactant gas is in contact with said array of materials; activating at least one of said materials on said array with a heating source; and periodically monitoring an infrared emission from said activated material with an infrared camera, wherein said infrared camera outputs a series of signals corresponding to an emission intensity varying with time of said activated material.

公开(公告)号：DE69730883D1

公开(公告)日：2004-10-28

申请号：DE69730883

申请日：1997-10-08

Applicant: SYMYX TECHNOLOGIES INC

Inventor： WEINBERG W HENRY ,  MCFARLAND ERIC W ,  CONG PEIJUN ,  GUAN SHENHENG

IPC: B01J19/00 ,  C07B61/00 ,  C07F15/00 ,  C07F15/04 ,  C08F10/00 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/14 ,  G01H13/00 ,  G01J4/00 ,  G01N3/00 ,  G01N9/00 ,  G01N21/21 ,  G01N21/25 ,  G01N21/64 ,  G01N21/66 ,  G01N29/02 ,  G01N29/036 ,  G01N29/24 ,  G01N29/34 ,  G01N29/42 ,  G01N29/44 ,  G01N33/53 ,  G01N33/543 ,  H01J49/00 ,  H01J49/04 ,  H03H9/19

Abstract: A method of characterizing materials comprising the steps of: providing a substrate; synthesizing an array of materials on said substrate; providing at least one reactant gas wherein said reactant gas is in contact with said array of materials; activating at least one of said materials on said array with a heating source; and periodically monitoring an infrared emission from said activated material with an infrared camera, wherein said infrared camera outputs a series of signals corresponding to an emission intensity varying with time of said activated material.

公开(公告)号：CA2499298A1

公开(公告)日：2004-04-29

申请号：CA2499298

申请日：2003-10-17

Applicant: SYMYX TECHNOLOGIES INC

Inventor： PINKAS DANIEL M ,  MATSIEV LEONID ,  BENNETT JAMES ,  SPITKOVSKY MIKHAIL ,  KOLOSOV OLEG ,  GUAN SHENHENG

IPC: G01F23/296 ,  G01N9/00 ,  G01N11/16 ,  G01N29/036 ,  G01N29/34 ,  G01N29/02

Abstract: A method for analyzing a fluid contained within a machine, comprising the steps of providing a machine system (100) including a passage (104) for containing a fluid; placing a sensor (106) including a mechanical resonator in the passage; operating the resonator to have a portion thereof translate through the fluid; and monitoring the response of the resonator to the fluid in the passage. One specific sensor includes a tuning fork resonator.

公开(公告)号：DE69714789T4

公开(公告)日：2004-04-22

申请号：DE69714789

申请日：1997-10-08

Applicant: SYMYX TECHNOLOGIES INC

Inventor： WEINBERG HENRY ,  MCFARLAND W ,  CONG PEIJUN ,  GUAN SHENHENG

IPC: B01J19/00 ,  C07B61/00 ,  C07F15/00 ,  C07F15/04 ,  C08F10/00 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/14 ,  G01H13/00 ,  G01J4/00 ,  G01N3/00 ,  G01N9/00 ,  G01N21/21 ,  G01N21/25 ,  G01N21/64 ,  G01N21/66 ,  G01N29/02 ,  G01N29/036 ,  G01N29/24 ,  G01N29/34 ,  G01N29/42 ,  G01N29/44 ,  G01N33/53 ,  G01N33/543 ,  H01J49/00 ,  H01J49/04 ,  H03H9/19

Abstract: A method of characterizing materials comprising the steps of: providing a substrate; synthesizing an array of materials on said substrate; providing at least one reactant gas wherein said reactant gas is in contact with said array of materials; activating at least one of said materials on said array with a heating source; and periodically monitoring an infrared emission from said activated material with an infrared camera, wherein said infrared camera outputs a series of signals corresponding to an emission intensity varying with time of said activated material.

公开(公告)号：DE69901996T2

公开(公告)日：2002-10-31

申请号：DE69901996

申请日：1999-06-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： GUAN SHENHENG ,  VANERDEN LYNN ,  HAUSHALTER ROBERT C ,  ZIIOU XIAO PING ,  WANG XUEJUN JASON ,  SRINIVASAN RAVI

IPC: G01N37/00 ,  B01J4/00 ,  B01J19/00 ,  C40B30/00 ,  C40B30/08 ,  C40B40/18 ,  C40B60/12 ,  G01N30/24 ,  G01N31/10 ,  G01N35/10 ,  B01L3/02 ,  B01L3/00

公开(公告)号：CA2297725A1

公开(公告)日：1999-12-16

申请号：CA2297725

申请日：1999-06-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： HAUSHALTER BOB ,  WANG JASON ,  ZHOU XIAO PING ,  SRINIVASAN RAVI ,  GUAN SHENHENG ,  VAN ERDEN LYNN

IPC: G01N37/00 ,  B01J4/00 ,  B01J19/00 ,  C40B30/00 ,  C40B30/08 ,  C40B40/18 ,  C40B60/12 ,  G01N30/24 ,  G01N31/10 ,  G01N35/10 ,  B01L3/02 ,  B01L3/00

Abstract: The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.

公开(公告)号：WO0051720A9

公开(公告)日：2002-03-14

申请号：PCT/US0005572

申请日：2000-03-03

Applicant: SYMYX TECHNOLOGIES INC

Inventor： BERGH S HOWARD ,  GUAN SHENHENG

IPC: B01F5/06 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  C01B3/40 ,  C07C17/23 ,  C07C45/34 ,  C07C45/35 ,  C07C45/38 ,  C07C45/46 ,  C07C45/50 ,  C07C45/54 ,  C07C45/72 ,  C40B30/08 ,  C40B40/18 ,  G01N30/90 ,  G01N31/10 ,  G01N35/00 ,  G01N35/02

CPC classification number: B01L3/5027 ,  B01F5/0601 ,  B01F15/0264 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00308 ,  B01J2219/00337 ,  B01J2219/00353 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00452 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00641 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00783 ,  B01J2219/00835 ,  B01J2219/00871 ,  B01L3/0293 ,  B01L3/5025 ,  B01L3/502707 ,  B01L7/54 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/14 ,  B01L2300/18 ,  B01L2400/0487 ,  C01B3/40 ,  C07C17/23 ,  C07C45/34 ,  C07C45/35 ,  C07C45/38 ,  C07C45/46 ,  C07C45/54 ,  C07C45/72 ,  C40B30/08 ,  C40B40/18 ,  G01N30/90 ,  G01N31/10 ,  G01N35/028 ,  G01N2035/00158 ,  C07C47/06 ,  C07C47/22 ,  C07C47/04 ,  C07C49/403 ,  C07C47/127 ,  G01N30/466

Abstract: A chemical processing microsystem useful for identifying and optimizing materials (e.g., catalysts) that enhance chemical processes or for characterizing and/or optimizing chemical processes is disclosed. The chemical processing microsystem comprises a plurality of microreactors (600) and, in a preferred embodiment, a plurality of microseparators (900) integral with the chemical processing microsystem (10). The microreactors (600) are preferably diffusion-mixed microreactors formed in a plurality of laminae that include a modular, interchangeable candidate-material array (100). The material array (100) comprises a plurality of different candidate materials (e.g., catalysts), preferably arranged at separate, individually addressable portions of a substrate (e.g., wafer). The microseparators (900) are similarly formed in a plurality of laminae that include a modular, interchangeable adsorbent array (700). The adsorbent array (700) comprises one or more adsorbents, preferably arranged at separate, individually addressable portions of a substrate to spatially correspond to the plurality of different candidate materials. Modular microfluidic distribution systems are also disclosed. The chemical processing microsystem can be integrated into a material evaluation system that enables a comprehensive combinatorial material science research program.

Abstract translation: 公开了一种用于识别和优化增强化学过程或表征和/或优化化学过程的材料（例如催化剂）的化学处理微系统。 化学处理微系统包括多个微反应器（600），并且在优选实施例中，与化学处理微系统（10）成一体的多个微分离器（900）。 微反应器（600）优选是形成在多个层中的扩散混合微反应器，其包括模块化的可互换的候选材料阵列（100）。 材料阵列（100）包括多个不同的候选材料（例如，催化剂），优选地布置在基板（例如，晶片）的单独可单独寻址的部分。 微分离器（900）类似地形成在包括模块化的可互换吸附剂阵列（700）的多个层中。 吸附剂阵列（700）包括一个或多个吸附剂，优选地布置在基板的分开的，可单独寻址的部分上，以在空间上对应于多种不同的候选材料。 还公开了模块化微流体分布系统。 化学加工微系统可以整合到材料评估系统中，实现全面的组合材料科学研究计划。

公开(公告)号：WO2004036191B1

公开(公告)日：2004-07-08

申请号：PCT/US0332982

申请日：2003-10-17

Applicant: SYMYX TECHNOLOGIES INC ,  MATSIEV LEONID ,  BENNETT JAMES ,  PINKAS DANIEL M ,  SPITKOVSKY MIKHAIL ,  KOLOSOV OLEG ,  GUAN SHENHENG

Inventor： MATSIEV LEONID ,  BENNETT JAMES ,  PINKAS DANIEL M ,  SPITKOVSKY MIKHAIL ,  KOLOSOV OLEG ,  GUAN SHENHENG

IPC: G01F23/296 ,  G01N9/00 ,  G01N11/16 ,  G01N29/036 ,  G01N29/34 ,  G01N29/02

CPC classification number: F02D41/021 ,  F02D2200/0611 ,  F02D2250/11 ,  G01F23/2966 ,  G01N9/002 ,  G01N11/16 ,  G01N29/022 ,  G01N29/036 ,  G01N29/30 ,  G01N29/348 ,  G01N2291/014 ,  G01N2291/0226 ,  G01N2291/02416 ,  G01N2291/02818 ,  G01N2291/02836 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427

Abstract: A method for analyzing a fluid contained within a machine, comprising the steps of providing a machine system (100) including a passage (104) for containing a fluid; placing a sensor (106) including a mechanical resonator in the passage; operating the resonator to have a portion thereof translate through the fluid; and monitoring the response of the resonator to the fluid in the passage. One specific sensor includes a tuning fork resonator.

Abstract translation: 一种用于分析包含在机器内的流体的方法，包括提供包括用于容纳流体的通道（104）的机器系统（100）的步骤; 将包括机械谐振器的传感器（106）放置在所述通道中; 操作谐振器以使其一部分翻转通过流体; 以及监测谐振器对通道中流体的响应。 一个具体的传感器包括音叉谐振器。

公开(公告)号：WO0204112A9

公开(公告)日：2002-10-10

申请号：PCT/US0121718

申请日：2001-07-09

Applicant: SYMYX TECHNOLOGIES INC

Inventor： HAGEMEYER ALFRED ,  VOLPE ANTHONY F JR ,  LEFORT LAURENT ,  LUGMAIR CLAUS ,  LOWE DAVID M ,  LIU YUMIN ,  BERGH H SAM ,  GUAN SHENHENG ,  PINKAS DANIEL M ,  ENGSTROM JAMES R ,  SELF KYLE W

IPC: B01J19/00 ,  B01J37/00 ,  C40B30/08 ,  C40B40/18 ,  G01N31/10

CPC classification number: B07B1/00 ,  B01J19/0046 ,  B01J35/10 ,  B01J37/0036 ,  B01J37/009 ,  B01J2219/00313 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/007 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00756 ,  B01L3/5025 ,  B22F2998/00 ,  C40B30/08 ,  C40B40/18 ,  G01N31/10 ,  B22F9/04

Abstract: Protocols for designing and implementing sets of simultaneous experiments, in a parallel, multi-variable process optimization reactor, are disclosed. The multi-variable process optimization reactor is preferably a parallel flow reactor having the operational capability to simultaneously vary reaction conditions between reaction vessels - either modularly or independently. The simultaneously varied reaction conditions preferably include at least two of the following, in various combinations and permutations: space velocity, contact time, temperature, pressure and feed composition. Compositional variations in the catalysts residing in each of the reaction vessels can also be investigated in the set of simultaneous experiments implemented in the parallel reactor. Sufficient data is obtained from a single set of simultaneous experiments to generate a master curve.

Abstract translation: 公开了在并行，多变量过程优化反应器中设计和实施多组同时进行的实验的协议。 多变量过程优化反应器优选是具有操作能力的并流反应器，以便同时改变反应容器之间的反应条件 - 模块化或独立。 同时改变的反应条件优选包括以下各项中的至少两种，以各种组合和置换：空间速度，接触时间，温度，压力和进料组成。 驻留在每个反应容器中的催化剂的组成变化也可以在平行反应器中实施的一组同时实验中进行研究。 从一组同时进行的实验中获得足够的数据以生成主曲线。