公开(公告)号：CA2796602A1

公开(公告)日：2011-10-27

申请号：CA2796602

申请日：2011-04-22

Applicant: VERTEX PHARMA

Inventor： VAN GOOR FREDRICK F ,  ALARGOVA ROSSITZA GUEORGUIEVA ,  ALCACIO TIM EDWARD ,  AREKAR SNEHA G ,  BINCH HAYLEY MARIE ,  BOTFIELD MARTYN CURTIS ,  FANNING LEV TYLER DEWEY ,  GROOTENHUIS PETER DIEDERIK JAN ,  HURLEY DENNIS JAMES ,  JOHNSTON STEVEN C ,  KADIYALA IRINA NIKOLAEVNA ,  KAUSHIK RITU ROHIT ,  KESHAVARZ-SHOKRI ALI ,  KRAWIEC MARIUSZ ,  LEE ELAINE CHUNGMIN ,  LUISI BRIAN ,  MEDEK ALES ,  MUDUNURI PRAVEEN ,  NUMA MEHDI ,  SHETH URVI JAGDISHBHAI ,  SILINA ALINA ,  SULLIVAN MARK JEFFREY ,  VERWIJS MARINUS JACOBUS ,  YANG XIAOQING ,  YOUNG CHRISTOPHER RYAN ,  ZAMAN NOREEN TASNEEM ,  ZHANG BEILI ,  ZHANG YUEGANG ,  ZLOKARNIK GREGOR

IPC: A61K31/4704 ,  A61K31/404 ,  A61K31/443

Abstract: The present invention relates to pharmaceutical compositions comprising a compound of Formulas I and II, optionally in combination with a Compound of Formula III and/or a Compound of Formula IV. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.

公开(公告)号：CA2778493A1

公开(公告)日：2011-04-28

申请号：CA2778493

申请日：2010-10-21

Applicant: VERTEX PHARMA

Inventor： ZHANG BEILI ,  KRAWIEC MARIUSZ ,  LUISI BRIAN ,  MEDEK ALES

IPC: C07D487/08 ,  A61K31/407 ,  A61P11/00

Abstract: The present invention relates to substantially crystalline and solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide (Form A-HCl, Form B, Form B-HCl, or any combination of these forms), pharmaceutical compositions thereof, and methods of treatment therewith.

公开(公告)号：AU2009308241A1

公开(公告)日：2010-04-29

申请号：AU2009308241

申请日：2009-10-23

Applicant: VERTEX PHARMA

Inventor： ZHANG BEILI ,  KRAWIEC MARIUSZ ,  BOTFIELD MARTYN ,  GROOTENHUIS PETER D J ,  GOOR FREDRICK VAN

IPC: C07D215/56 ,  A61K31/4704 ,  A61P1/00 ,  A61P11/00

公开(公告)号：CA2986286A1

公开(公告)日：2009-06-11

申请号：CA2986286

申请日：2008-12-04

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  KRAWIEC MARIUSZ

IPC: A61K31/47 ,  A61K31/443

Abstract: The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Form I), pharmaceutical compositions thereof, and methods of treatment therewith.

公开(公告)号：CA2706920A1

公开(公告)日：2009-06-11

申请号：CA2706920

申请日：2008-12-04

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  KRAWIEC MARIUSZ

IPC: C07D405/12 ,  A61K31/443 ,  A61P11/00

Abstract: The present invention relates to a substantially crystalline and free solid state form of 3-(6-(l-(2,2-difluorobenzo[d][l,3]dioxol-5-yl) cyclopropanecarboxamido)-3- methylPyridin-2-yl)benzoic acid (Form I) of following formula: (I), pharmaceutical compositions thereof, and methods of treatment therewith.

公开(公告)号：AU2008333845A1

公开(公告)日：2009-06-11

申请号：AU2008333845

申请日：2008-12-04

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  KRAWIEC MARIUSZ

IPC: C07D405/12 ,  A61K31/443 ,  A61P11/00

Abstract: The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Form I), pharmaceutical compositions thereof, and methods of treatment therewith.

公开(公告)号：HUE062892T2

公开(公告)日：2023-12-28

申请号：HUE20206423

申请日：2011-03-25

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  ALCACIO TIM EDWARD ,  LEE ELAINE CHUNGMIN ,  ZHANG YUEGANG ,  KRAWIEC MARIUSZ

IPC: C07D405/12

公开(公告)号：BR112012024338B1

公开(公告)日：2021-09-28

申请号：BR112012024338

申请日：2011-03-25

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEIL ,  ELAINE CHUNGMIN LEE ,  KRAWIEC MARIUSZ ,  TIM EDWARD ALCACIO ,  ZHANG YUEGANG

IPC: C07D405/12 ,  A61K31/404 ,  A61P11/00

Abstract: formas sólidas de (r)-1-(2,2-difluorbenzo[d][1,3]dioxol-5-il)-n-(1-(2,3-diidroxipropil)-6-flúor-2-(1-hidróxi-2-metilpropan-2-il)-1h-indol-5-il) ciclopropanocarboxamida, composições farmacêuticas e dispersões sólidas compreendendo as mesmas, processo de preparação e usos das mesmas, e kit compreendendo as mesmas. a presente invenção se refere às formas sólidas de (r)-1-(2,2-diflúorbenzo[d][1,3]dioxol-5-il)-n-(1-(2,3-diidroxipropil)-6-flúor-2-(1-hidróxi-2-metilpropan-2-il)-1h-indol-5-il)ciclopropanocarboxamida (composto 1) na forma substancialmente cristalina (forma a) ou forma amorfa, composições farmacêuticas das mesmas e usos das mesmas.

公开(公告)号：ES2804202T3

公开(公告)日：2021-02-04

申请号：ES17154840

申请日：2011-03-25

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  ALCACIO TIM EDWARD ,  LEE ELAINE CHUNGMIN ,  ZHANG YUEGANG ,  KRAWIEC MARIUSZ ,  NUGENT WILLIAM A

IPC: C07D405/12

Abstract: Un compuesto de la fórmula: **(Ver fórmula)** o una sal del mismo.

公开(公告)号：DK2826776T3

公开(公告)日：2020-12-14

申请号：DK14172991

申请日：2011-03-25

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  LEE ELAINE CHUNGMIN ,  ZHANG YUEGANG ,  KRAWIEC MARIUSZ ,  ALCACIO TIM EDWARD

IPC: A61K9/10 ,  A61K31/404 ,  A61P11/00 ,  C07D405/12