公开(公告)号：HUE054031T2

公开(公告)日：2021-08-30

申请号：HUE18186230

申请日：2013-04-23

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  COTTRELL KEVIN MICHAEL ,  DENG HONGBO ,  DUFFY JOHN P ,  GAO HUAI ,  GIROUX SIMON ,  GREEN JEREMY ,  JACKSON KATRINA LEE ,  MAXWELL JOHN PATRICK ,  MORRIS MARK A ,  PIERCE ALBERT CHARLES ,  WAAL NATHAN D ,  KENNEDY JOSEPH M ,  LAUFFER DAVID J ,  LEDEBOER MARK WILLEM ,  LI PAN ,  XU JINWANG

IPC: C07D401/14 ,  A61K41/00 ,  A61P35/00 ,  C07D239/42 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

公开(公告)号：CA2904641C

公开(公告)日：2021-07-20

申请号：CA2904641

申请日：2014-03-12

Applicant: VERTEX PHARMA

Inventor： JACKSON KATRINA LEE ,  PIERCE ALBERT CHARLES ,  LAUFFER DAVID J ,  LI PAN ,  GIROUX SIMON ,  MAXWELL JOHN PATRICK ,  CHARIFSON PAUL S ,  TANG QING ,  RONKIN STEVEN M ,  WAAL NATHAN D ,  XU JINWANG ,  GU WENXIN ,  MORRIS MARK A ,  COTTRELL KEVIN M ,  COURT JOHN J ,  DENG HONGBO

IPC: C07D403/12 ,  A61K31/517 ,  A61P35/00 ,  C07D405/12 ,  C07D413/04 ,  C07D417/12 ,  C07D491/052

Abstract: The present invention relates to compounds (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：AU2019261308A1

公开(公告)日：2020-10-22

申请号：AU2019261308

申请日：2019-04-23

Applicant: MERCK PATENT GMBH ,  VERTEX PHARMA

Inventor： YU HENRY ,  CLARK MICHAEL ,  BEMIS GUY ,  BOYD MICHAEL ,  CHANDUPATLA KISHAN ,  COLLIER PHILIP ,  DENG HONGBO ,  DONG HUIJUN ,  DORSCH WARREN ,  HOOVER RUSSELL R ,  JOHNSON JR MAC ARTHUR ,  KUKAMI SHASHANK ,  PENNEY MARINA ,  RONKIN STEVEN ,  TAKEMOTO DARIN ,  TANG QING ,  WAAL NATHAN D ,  WANG TIANSHENG ,  LAUFFER DAVID J ,  LI PAN

IPC: C07D413/14 ,  A61K31/553 ,  A61P35/00 ,  C07D403/04 ,  C07D409/14 ,  C07D413/04

Abstract: The present invention provides compounds of Formula (I'), or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g. cancer).

公开(公告)号：AU2019257651A1

公开(公告)日：2020-10-15

申请号：AU2019257651

申请日：2019-04-23

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID J ,  BEMIS GUY ,  BOYD MICHAEL ,  DEININGER DAVID ,  DENG HONGBO ,  DORSCH WARREN ,  GU WENXIN ,  HOOVER RUSSELL R ,  JOHNSON JR MAC ARTHUR ,  LEDEBOER MARK WILLEM ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PENNEY MARINA ,  TAKEMOTO DARIN ,  WAAL NATHAN D ,  WENG TIANSHENG ,  LI PAN

IPC: C07D471/04 ,  A61K31/505 ,  A61P35/00 ,  C07D475/04

Abstract: The present invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for reating cellular proliferate disorders (e.g. cancer).

公开(公告)号：AU2017239481B2

公开(公告)日：2019-05-16

申请号：AU2017239481

申请日：2017-10-03

Applicant: VERTEX PHARMA

Inventor： GAO HUAI ,  CHARIFSON PAUL S ,  COTTRELL KEVIN MICHAEL ,  DENG HONGBO ,  DUFFY JOHN P ,  GIROUX SIMON ,  GREEN JEREMY ,  JACKSON KATRINA LEE ,  MAXWELL JOHN PATRICK ,  MORRIS MARK A ,  PIERCE ALBERT CHARLES ,  WAAL NATHAN D ,  LAUFFER DAVID J ,  KENNEDY JOSEPH M ,  LEDEBOER MARK WILLEM ,  LI PAN ,  XU JINWANG

IPC: C07D401/14 ,  C07D239/42 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048

Abstract: Abstract N' -QR The present invention relates to compounds of following formula (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders, such as cancer.

公开(公告)号：RS58374B1

公开(公告)日：2019-03-29

申请号：RSP20190243

申请日：2014-03-12

Applicant: VERTEX PHARMA

Inventor： MAXWELL JOHN PATRICK ,  CHARIFSON PAUL S ,  TANG QING ,  RONKIN STEVEN M ,  JACKSON KATRINA LEE ,  PIERCE ALBERT CHARLES ,  LAUFFER DAVID J ,  LI PAN ,  GIROUX SIMON ,  XU JINWANG ,  MORRIS MARK A ,  COURT JOHN J ,  COTTRELL KEVIN M ,  DENG HONGBO ,  WAAL NATHAN D ,  GU WENXIN

IPC: C07D403/12 ,  A61K31/517 ,  A61P35/00 ,  C07D405/12 ,  C07D413/04 ,  C07D417/12 ,  C07D491/052

公开(公告)号：SI2841428T1

公开(公告)日：2018-12-31

申请号：SI201331260

申请日：2013-04-23

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  COTTRELL KEVIN MICHAEL ,  DENG HONGBO ,  DUFFY JOHN P ,  GAO HUAI ,  GIROUX SIMON ,  GREEN JEREMY ,  JACKSON KATRINA LEE ,  MAXWELL JOHN PATRICK ,  MORRIS MARK A ,  PIERCE ALBERT CHARLES ,  WAAL NATHAN D ,  KENNEDY JOSEPH M ,  LAUFFER DAVID J ,  LEDEBOER MARK WILLEM ,  LI PAN ,  XU JINWANG

IPC: C07D401/00 ,  C07D239/00 ,  C07D403/00 ,  C07D405/00 ,  C07D409/00 ,  C07D413/00 ,  C07D417/00 ,  C07D471/00 ,  C07D491/00

公开(公告)号：AU2018236800A1

公开(公告)日：2018-10-25

申请号：AU2018236800

申请日：2018-09-27

Applicant: VERTEX PHARMA

Inventor： JACKSON KATRINA LEE ,  PIERCE ALBERT CHARLES ,  LAUFFER DAVID J ,  LI PAN ,  GIROUX SIMON ,  XU JINWANG ,  COTTRELL KEVIN M ,  MORRIS MARK A ,  WAAL NATHAN D ,  COURT JOHN J ,  GU WENXIN ,  DENG HONGBO ,  MAXWELL JOHN PATRICK ,  CHARIFSON PAUL S ,  TANG QING ,  RONKIN STEVEN M

IPC: C07D403/12 ,  A61K31/517 ,  A61P35/00 ,  C07D405/12 ,  C07D413/04 ,  C07D417/12 ,  C07D491/052

Abstract: The present invention relates to compounds (1) which are useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders related to undesirable DNA-PK activity. (I)

公开(公告)号：AU2017239481A1

公开(公告)日：2017-10-26

申请号：AU2017239481

申请日：2017-10-03

Applicant: VERTEX PHARMA

Inventor： GAO HUAI ,  CHARIFSON PAUL S ,  COTTRELL KEVIN MICHAEL ,  DENG HONGBO ,  DUFFY JOHN P ,  GIROUX SIMON ,  GREEN JEREMY ,  JACKSON KATRINA LEE ,  MAXWELL JOHN PATRICK ,  MORRIS MARK A ,  PIERCE ALBERT CHARLES ,  WAAL NATHAN D ,  LAUFFER DAVID J ,  KENNEDY JOSEPH M ,  LEDEBOER MARK WILLEM ,  LI PAN ,  XU JINWANG

IPC: C07D401/14 ,  C07D239/42 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048

Abstract: Abstract N' -Q R1 The present invention relates to compounds of following formula (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders, such as cancer.

公开(公告)号：SG10201704095UA

公开(公告)日：2017-06-29

申请号：SG10201704095U

申请日：2013-04-23

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  COTTRELL KEVIN MICHAEL ,  GAO HUAI ,  DENG HONGBO ,  DUFFY JOHN P ,  GIROUX SIMON ,  GREEN JEREMY ,  JACKSON KATRINA LEE ,  MAXWELL JOHN PATRICK ,  MORRIS MARK A ,  PIERCE ALBERT CHARLES ,  WAAL NATHAN D ,  LAUFFER DAVID J ,  KENNEDY JOSEPH M ,  LEDEBOER MARK WILLEM ,  LI PAN ,  XU JINWANG

Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.