公开(公告)号：CA2986286A1

公开(公告)日：2009-06-11

申请号：CA2986286

申请日：2008-12-04

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  KRAWIEC MARIUSZ

IPC: A61K31/47 ,  A61K31/443

Abstract: The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Form I), pharmaceutical compositions thereof, and methods of treatment therewith.

公开(公告)号：CA2706920A1

公开(公告)日：2009-06-11

申请号：CA2706920

申请日：2008-12-04

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  KRAWIEC MARIUSZ

IPC: C07D405/12 ,  A61K31/443 ,  A61P11/00

Abstract: The present invention relates to a substantially crystalline and free solid state form of 3-(6-(l-(2,2-difluorobenzo[d][l,3]dioxol-5-yl) cyclopropanecarboxamido)-3- methylPyridin-2-yl)benzoic acid (Form I) of following formula: (I), pharmaceutical compositions thereof, and methods of treatment therewith.

公开(公告)号：AU2008333845A1

公开(公告)日：2009-06-11

申请号：AU2008333845

申请日：2008-12-04

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  KRAWIEC MARIUSZ

IPC: C07D405/12 ,  A61K31/443 ,  A61P11/00

Abstract: The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Form I), pharmaceutical compositions thereof, and methods of treatment therewith.

公开(公告)号：LT3519401T

公开(公告)日：2021-11-25

申请号：LT17054611

申请日：2017-09-29

Applicant: VERTEX PHARMA

Inventor： ALCACIO TIMOTHY ,  BAEK MINSON ,  GROOTENHUIS PETER ,  HADIDA RUAH SARA ,  HUGHES ROBERT ,  KESHAVARZ-SHOKRI ALI ,  MCAULEY-AOKI RACHEL ,  MCCARTNEY JASON ,  MILLER MARK ,  VAN GOOR FREDRICK ,  ZHANG BEILI ,  ANDERSON COREY ,  CLEVELAND THOMAS ,  FRIEMAN BRYAN ,  KHATUYA HARIPADA ,  JOSHI PRAMOD ,  KRENITSKY PAUL ,  MELILLO VITO ,  PIERRE FABRICE ,  TERMIN ANDREAS ,  UY JOHNNY ,  ZHOU JINGLAN ,  ABELA ALEXANDER ,  BUSCH BRETT ,  PARASELLI PRASUNA ,  SIESEL DAVID

IPC: C07D401/14 ,  A61K31/4439 ,  A61P1/16 ,  A61P1/18 ,  A61P11/00 ,  A61P11/12 ,  A61P43/00 ,  C07D471/14 ,  C07D498/14

公开(公告)号：HRP20210165T1

公开(公告)日：2021-03-19

申请号：HRP20210165

申请日：2021-02-01

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  ALCACIO TIM EDWARD ,  LEE ELAINE CHUNGMIN ,  ZHANG YUEGANG ,  KRAWIEC MARIUSZ

IPC: A61K9/10 ,  A61K31/404 ,  A61P11/00 ,  C07D405/12

公开(公告)号：SI2826776T1

公开(公告)日：2021-02-26

申请号：SI201131935

申请日：2011-03-25

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  ALCACIO TIM EDWARD ,  LEE ELAINE CHUNGMIN ,  ZHANG YUEGANG ,  KRAWIEC MARIUSZ

IPC: A61K9/00 ,  A61K31/00 ,  A61P11/00 ,  C07D405/00

公开(公告)号：LT3170818T

公开(公告)日：2020-05-25

申请号：LT16198922

申请日：2008-12-04

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  KRAWIEC MARIUSZ

IPC: C07D405/12 ,  A61K31/4709 ,  A61P11/00

公开(公告)号：SG10201913595YA

公开(公告)日：2020-02-27

申请号：SG10201913595Y

申请日：2017-09-29

Applicant: VERTEX PHARMA

Inventor： ALCACIO TIMOTHY ,  BAEK MINSON ,  GROOTENHUIS PETER ,  HADIDA RUAH SARA SABINA ,  HUGHES ROBERT M ,  KESHAVARZ-SHOKRI ALI ,  MCAULEY-AOKI RACHEL ,  MCCARTNEY JASON ,  MILLER MARK THOMAS ,  VAN GOOR FREDRICK ,  ZHANG BEILI ,  ANDERSON COREY ,  CLEVELAND THOMAS ,  FRIEMAN BRYAN A ,  KHATUYA HARIPADA ,  JOSHI PRAMOD VIRUPAX ,  KRENITSKY PAUL JOHN ,  MELILLO VITO ,  PIERRE FABRICE JEAN DENIS ,  TERMIN ANDREAS P ,  UY JOHNNY ,  ZHOU JINGLAN ,  ABELA ALEXANDER RUSSELL ,  BUSCH BRETT BRADLEY ,  PARASELLI PRASUNA ,  SIESEL DAVID ANDREW

Abstract: Compounds of Formula I:pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

公开(公告)号：CA2794559C

公开(公告)日：2019-07-23

申请号：CA2794559

申请日：2011-03-25

Applicant: VERTEX PHARMA

Inventor： KESHAVARZ-SHOKRI ALI ,  ZHANG BEILI ,  ALCACIO TIM EDWARD ,  LEE ELAINE CHUNGMIN ,  ZHANG YUEGANG ,  KRAWIEC MARIUSZ

IPC: C07D405/12 ,  A61K31/404 ,  A61P11/00

Abstract: The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2- methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.

公开(公告)号：CR20190211A

公开(公告)日：2019-07-11

申请号：CR20190211

申请日：2017-09-29

Applicant: VERTEX PHARMA

Inventor： MCCARTNEY JASON ,  ANDERSON COREY ,  CLEVELAND THOMAS ,  JOSHI PRAMOD VIRUPAX ,  ZHOU JINGLAN ,  BAEK MINSON ,  FRIEMAN BRYAN A ,  BUSCH BRETT BRADLEY ,  SIESEL DAVID ANDREW ,  KESHAVARZ-SHOKRI ALI ,  MCAULEY-AOKI RACHEL ,  VAN GOOR FREDRICK ,  TERMIN ANDREAS P ,  PARASELLI PRASUNA ,  GROOTENHUIS PETER ,  HUGHES ROBERT M ,  ALCACIO TIMOTHY ,  HADIDA RUAH SARA SABINA ,  ZHANG BEILI ,  KRENITSKY PAUL JOHN ,  UY JOHNNY ,  KHATUYA HARIPADA; ,  MELILLO VITO; ,  MILLER MARK THOMAS ,  PIERRE FABRICE JEAN DENIS ,  ABELA ALEXANDER RUSSELL

IPC: C07D471/14 ,  A61K31/4439 ,  A61P11/12 ,  C07B59/00 ,  C07D401/14 ,  C07D498/14