公开(公告)号：TR201900706T4

公开(公告)日：2019-02-21

申请号：TR201900706

申请日：2012-01-13

Applicant: UNIV TAIPEI MEDICAL ,  ACADEMIA SINICA

Inventor： WEI-CHUNG YANG ,  HWEI-JIUNG WANG ,  SHUI-TSUNG CHEN ,  KEN-FEN LU ,  MING-CHI PENG

IPC: C12P21/06 ,  G01N33/68

Abstract: Alfa 1-antitripsin (A1AT) izoformlarına yüksek bağlanma afinitesine sahip monoklonal antikorlar, aynı üreten hibridoma hücreleri ve endometriozis şüpheli bir deneğin veya sağlık muayenesi altındaki deneğin serum numunesinden endometriozisin teşhisi ve / veya saptanmasında kullanımları açıklanmaktadır.

公开(公告)号：NZ723520A

公开(公告)日：2018-06-29

申请号：NZ72352015

申请日：2015-06-16

Applicant: ACADEMIA SINICA

Inventor： CHEN JIUN-BO ,  SHIUNG YU-YU ,  CHANG TSE-WEN

IPC: C07K16/00 ,  A61K39/00 ,  C12P21/08

Abstract: A humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, and IgE bound by CD23, but not to IgE bound by FcɛRI. The CDR-H1, CDR-H2 and CDR-H3 of the antibody respectively comprise the amino acid sequences of SEQ ID NOs: 5-7, and the CDR-L1, CDR-L2 and CDR-L3 of the antibody respectively comprise the amino acid sequences of SEQ ID NOs: 8-10.

公开(公告)号：BRPI1008317A2

公开(公告)日：2018-03-13

申请号：BRPI1008317

申请日：2010-02-25

Applicant: ACADEMIA SINICA

Inventor： ALFUR F HUNG ,  JIUN-BO CHEN ,  PHEIDIAS C WU ,  TSEWEN CHANG

IPC: A61K39/395 ,  A61K38/10 ,  A61P37/00 ,  C07K16/28

公开(公告)号：AU2016203431B2

公开(公告)日：2018-03-08

申请号：AU2016203431

申请日：2016-05-25

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

IPC: A61K39/12

Abstract: METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein El or E2 and HIV glycoproteins gp120 and gp4l.

公开(公告)号：BR112016013242A2

公开(公告)日：2018-01-16

申请号：BR112016013242

申请日：2014-12-10

Applicant: ACADEMIA SINICA ,  UNIV OREGON STATE ,  UNIV WIEN TECH

Inventor： FREITAG MICHAEL ,  POMRANING KYLE ,  SCHMOLL MONIKA ,  SCHUSTER ANDRE ,  TISCH DORIS ,  WANG TING FANG

IPC: C07K14/37 ,  C12N1/14 ,  C12P21/02 ,  C12R1/885

Abstract: a presente invenção está relacionada a uma cepa variante feminina fértil de fungo filamentoso derivada de uma cepa parental feminina estéril, a qual compreende pelo menos um dos seis alelos do gene específico para fertilidade feminina ou derivados destes, compreendendo as características funcionais destes alelos (fs_4-9).

公开(公告)号：ES2645043T3

公开(公告)日：2017-12-01

申请号：ES10859431

申请日：2010-11-12

Applicant: ACADEMIA SINICA

Inventor： LIN YUN-LIAN ,  CHERN YIJUANG ,  FANG JIM-MIN ,  LIN JUNG-HSING ,  HUANG NAI-KUEI

IPC: C07H19/167 ,  A61K31/426 ,  A61K31/56 ,  A61P11/06

Abstract: Una composición que comprende una cantidad eficaz de un compuesto de fórmula:**Fórmula** en donde n es 1 a 3, el heterociclo (sustituido) contiene anillos de 5 o 6 miembros y el heterociclo fusionado contiene heteroátomos de nitrógeno, oxígeno o azufre y el sustituyente se selecciona del grupo que consiste en hidrógeno, flúor, cloro, bromo, yodo, hidroxi, alquilo C1-6, trifluorometilo y fenilo (sustituido), para usar en el tratamiento de una enfermedad neurodegenerativa en un sujeto que lo necesite.

公开(公告)号：IL253497D0

公开(公告)日：2017-09-28

申请号：IL25349717

申请日：2017-07-16

Applicant: ACADEMIA SINICA

IPC: C07K20060101

Abstract: The present disclosure relates to compositions and methods of use comprising antibodies or binding fragments thereof further comprising universal Fc glycoforms.

公开(公告)号：IL253161D0

公开(公告)日：2017-08-31

申请号：IL25316117

申请日：2017-06-25

Applicant: ACADEMIA SINICA

IPC: A61K20060101

Abstract: The present disclosure is directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA3/SSEA4/GloboH associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globo-series glycosphingolipid synthesis. The present disclosure relates to methods and compositions which can modulate the globo-series glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globo-series glycosphingolipid SSEA3/SSEA4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globo-series synthetic pathway. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions.

公开(公告)号：AU2015377230A1

公开(公告)日：2017-07-13

申请号：AU2015377230

申请日：2015-07-13

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  HSU TSUI-LING ,  LOU YI-WEI ,  LIN CHIH-WEI ,  YEH SHIHH-CHI ,  WU CHUNG-YI ,  WU HAN-CHUNG

IPC: C07K16/00 ,  A61K39/42 ,  C07K16/28 ,  C07K16/30

Abstract: Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to globo H, SSEA3, and SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, skin, bone, lungs, breast, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervical, ovarian, and/or prostate cancer.

公开(公告)号：AU2015305332A1

公开(公告)日：2017-03-09

申请号：AU2015305332

申请日：2015-08-21

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  LEE HSIN-YU

IPC: C07K14/33 ,  C07K14/34

Abstract: This disclosure includes an immunogenic composition containing (a) a glycan conjugate including a carrier and one or more glycans, wherein each of the one or more glycans is conjugated with the carrier through a linker, and optionally (b) an adjuvant. The one or more glycan is each a Globo H derivative.