公开(公告)号：IL219898A

公开(公告)日：2016-06-30

申请号：IL21989812

申请日：2012-05-20

Applicant: ACADEMIA SINICA

IPC: A61K20060101 ,  A61K38/16 ,  A61P20060101

公开(公告)号：AU2014201215B2

公开(公告)日：2016-05-05

申请号：AU2014201215

申请日：2014-03-05

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  YU ALICE ,  YU JOHN

IPC: A61K39/00 ,  A61K39/385

Abstract: The present invention provides for an immunogenic composition comprising (a) a glycan, such as Globo H, stage-specific embryonic antigen-3 (SSEA-3) or SSEA-4, conjugated to a carrier protein through a linker; (b) an adjuvant comprising a glycolipid, such as a-galactosyl-ceramide adjuvant, wherein the composition induces an immune response, such as a higher relative level of IgG isotype antibodies compared to IgM isotype antibodies, or neutralising antibodies against at least one antigen selected from the group consisting of Globo H, Gb4, SSEA-3, and SSEA-4. Uses of the immunogenic composition for treating or inhibiting tumour growth are also provided.

公开(公告)号：IL244326D0

公开(公告)日：2016-04-21

申请号：IL24432616

申请日：2016-02-28

Applicant: ACADEMIA SINICA

IPC: A61K20060101

Abstract: Glycosphingolipids (GSLs) bearing α-glucose (α-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with α-glucose (α-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with α-galactose (α-Gal) are disclosed. GSLs bearing α-glucose (α-Glc) and derivatives of α-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with α-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with α-Glc and derivatives thereof are provided.

公开(公告)号：HK1208598A1

公开(公告)日：2016-03-11

申请号：HK15109316

申请日：2015-09-23

Applicant: ACADEMIA SINICA

Inventor： CHEN CHIH-CHENG ,  LIN YUN-LIAN ,  FANG JIM-MIN ,  CHERN YIJUANG ,  LIN CHIA-CHING JOHN ,  CHEN WEI-NAN ,  LIN CHUN-JUNG

IPC: A61K20060101 ,  A01N20060101

Abstract: The invention provides a new use of adenosine analogs for the treatment of pain through activation of neurokinin 1 (NK1) receptor signaling pathway, thereby inducing the activation of activation of M-type potassium channel to induce outward currents. A method and pharmaceutical composition for treating pain comprising an adenonsine analog that activates NK1 receptor signaling, thereby inducing outward current are also provided.

公开(公告)号：AU2010229675B2

公开(公告)日：2016-02-25

申请号：AU2010229675

申请日：2010-03-26

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

IPC: A61K39/12

Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

公开(公告)号：DK2568976T3

公开(公告)日：2016-01-11

申请号：DK11731548

申请日：2011-05-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  FANG JIM-MIN ,  CHENG YIH-SHYUN ,  SHIE JIUN-JIE

IPC: A61K31/00 ,  A61K31/665 ,  A61K31/683

公开(公告)号：CA2950415A1

公开(公告)日：2015-12-03

申请号：CA2950415

申请日：2015-05-27

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI MING-HUNG

IPC: C07K16/00

Abstract: The present disclosure relates to a novel class of anti-CD20 monoclonal antibodies comprising a homogeneous population of anti-CD20 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-CD20 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered.

公开(公告)号：DK2320947T3

公开(公告)日：2015-09-07

申请号：DK09795269

申请日：2009-07-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  YU ALICE ,  LIN KUN-HSIEN ,  CHENG EDMOND Y S ,  JAN JIA-TSRONG ,  LIN YI-LING ,  HUNG JUNG-TUNG ,  CHANG YA-JEN

IPC: A61K31/70 ,  C07H15/18 ,  A61K31/7034 ,  A61K39/00 ,  A61K39/39 ,  A61P31/04 ,  A61P31/16 ,  A61P35/00

公开(公告)号：AU2010321830B2

公开(公告)日：2015-06-11

申请号：AU2010321830

申请日：2010-11-19

Applicant: ACADEMIA SINICA

Inventor： LIANG SHU-MEI ,  CHIU CHING-FENG ,  HUNG SHAO-WEN ,  PENG JEI-MING ,  LIANG CHI-MING

IPC: A61K38/38 ,  A61K38/16 ,  A61K47/48 ,  C07K14/76

Abstract: Methods are provided for suppressing cancer metastasis. Cancer metastasis is the most common cause of treatment failure and death in cancer patients. Tumor cell invasion and/or migration can be significantly inhibited after fibrillar proteins (rVP1, F-HSA, and F-BSA) treatment

公开(公告)号：AU2013305937A1

公开(公告)日：2015-02-19

申请号：AU2013305937

申请日：2013-08-20

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI TSUNG-I

IPC: C12P19/04 ,  C12N9/10

Abstract: A novel UDP-Gal regeneration process and its combined use with a galactosyltransferease to add galactose to a suitable acceptor substrate. Also described herein are synthetic methods for generating Globo-series oligosaccharides in large scale, wherein the methods may involve the combination of a glycosyltransferase reaction and a nucleotide sugar regeneration process.