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公开(公告)号：KR1020010084806A
公开(公告)日：2001-09-06
申请号：KR1020000010120
申请日：2000-02-29
Applicant: (주)씨앤팜
CPC classification number: B01J20/103 , B01J20/28078
Abstract: PURPOSE: A preparation method of porous crosslinked clay is provided which is characterized in that nano-sol particles of cationic-surface reformed metallic oxide instead of cationic cluster compounds of metallic oxide in conventional method are used for ion-exchanging inorganic cations between layers of clay and crosslinking. Accordingly, the resultant crosslinked clay has much improved surface area and thermal stability. CONSTITUTION: The method comprises the steps of: preparing nano-sol particles of metallic oxide such as SiO2 or Fe2O3-SiO2; reforming the surface of particles by cationic complexing metal, Fe; ion exchanging and crosslinking by adding prepared nano-sol solution to a suspension of clay, as montmorillonite or smectite-based clay; centrifuging, washing with aid and freeze-drying crosslinked clay; calcining at 400-550deg.C. The organic surfactant or NH4F is added to improve porous characteristics in preparation of crosslinked clay which has 300-1000m2/g of surface area, 1-3nm of pore size and 500-800deg.C of thermal stability.
Abstract translation: 目的：提供一种多孔交联粘土的制备方法，其特征在于常规方法中阳离子表面改性金属氧化物的纳米溶胶颗粒代替金属氧化物的阳离子簇化合物用于离子交换粘土层之间的无机阳离子 和交联。 因此，所得交联粘土具有大大改善的表面积和热稳定性。 构成：该方法包括以下步骤：制备金属氧化物如SiO2或Fe2O3-SiO2的纳米溶胶颗粒; 通过阳离子络合金属Fe改性颗粒表面; 通过将制备的纳米溶胶溶液添加到粘土的悬浮液中作为蒙脱石或蒙脱石粘土进行离子交换和交联; 离心，辅助洗涤和冷冻干燥交联粘土; 焙烧400-550℃。 添加有机表面活性剂或NH4F以改善交联粘土的制备中的多孔特性，其具有300-1000m 2 / g的表面积，1-3nm的孔径和500-800deg的热稳定性。
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公开(公告)号：KR1020000019408A
公开(公告)日：2000-04-06
申请号：KR1019980037497
申请日：1998-09-11
Applicant: (주)씨앤팜
IPC: C07H19/00
CPC classification number: C12N15/1003
Abstract: PURPOSE: The aim is to provide a bio-inorganic hybrid complex which can carry genetic materials between layers of metal layered double hydroxide by anion exchange reaction. CONSTITUTION: The invention provides the complex of formula I (M2+1-xN3+x(OH)2)(An-)x/n·yH2O, wherein M represents metal cation such as Mg¬2+, Ni¬2+, Cu¬2+ and Zn¬2+ which are alkali-earth metals or transition metals having a valence of two. N represents metal cation such as Al¬3+, Cr¬3+, Fe¬3+, V¬3+ and Ga¬3+ which are transition metal having valence of three. A represents anionic bio-compounds such NO3¬-, CO3¬2-, Cl¬-, SO4¬2-, meta late and organic acid having a valence of n. 0 0. Charge of the layer can be controlled by changing the ratio of the metal according to X. This complex is non-toxic, reversibly dissociated and stable.
Abstract translation: 目的：提供一种可通过阴离子交换反应在金属层状双氢氧化物层之间携带遗传物质的生物 - 无机杂化复合物。 构成：本发明提供式I（M2 + 1-xN3 + x（OH）2）（An-）x / n·yH2O的络合物，其中M表示金属阳离子如Mg 2+，Ni 2+， Cu 2+和Zn 2+是碱土金属或二价过渡金属。 N表示作为三价的过渡金属的金属阳离子，例如Al 3+，Cr 3+，Fe 3+，V 3+和Ga 3+。 A表示阴离子生物化合物，例如NO 3 - ，CO 3 - ，Cl - ，SO 4 2-，间位延迟和n价的有机酸。 0
0.可以通过根据X改变金属的比例来控制层的电荷。该复合物是无毒的，可逆解离和稳定的。 -
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公开(公告)号：KR1020160113496A
公开(公告)日：2016-09-29
申请号：KR1020150039265
申请日：2015-03-20
Applicant: 이화여자대학교 산학협력단 , (주)씨앤팜
CPC classification number: A61K9/08 , A61K47/02 , A61K47/30 , A61K47/50 , A61K49/00 , A61K51/12 , A61K47/6905 , A61K49/0076 , A61K51/1217
Abstract: 본발명은무기고분자하이브리드콜로이드화합물및 그의제조방법에관한것으로, 보다상세하게는, 생리활성분자의존재하에서무기질염류의수열합성을통해, 균일한입도와형상을나타내며제타전위가 (+) 25 mV 이상또는 (-) 25 mV 이하인것을특징으로하는무기고분자하이브리드콜로이드화합물및 그의제조방법과이를포함한약제학적조성물에관한것이다. 본발명에따른초분자성하이브리드콜로이드화합물은안정한콜로이드물성을가짐으로인해, 약학, 의학, 화장품, 농약, 식품등의다양한분야에서유효성분물질의전달기술에널리활용될수 있다.
Abstract translation: 本发明涉及一种无机聚合物混合胶体化合物及其制造方法，更具体地涉及ζ电位大于或等于（+）25mV或小于等于（ - ）25mV，其制备方法和包含该方法的药物组合物。 无机聚合物杂化胶体化合物表现出均匀的粒度和形状，通过在生物活性分子存在下水热合成无机盐。 根据本发明，超分子混合胶体化合物具有稳定的胶体性质，广泛用于药理，医学，化妆品，农药，食品等各个领域中的活性成分的携带技术。
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45.发明公开
公开(公告)号：KR1020100086560A
公开(公告)日：2010-08-02
申请号：KR1020090005825
申请日：2009-01-23
Applicant: 이화여자대학교 산학협력단 , (주)씨앤팜
Abstract: PURPOSE: An organic/inorganic nanohybrid complex for preventing hair loss and promoting hair growth containing vitamin C is provided to ensure stability and to slowly release vitamin C. CONSTITUTION: A nanohybrid complex for preventing hair loss and promoting hair growth is inserted between a metal salt. The metal salt is layered double hybroxide(LDH) of metal double layer or zinc basic salt(ZBS). The LDH is denoted by structure formula (M^2+_(1-x)N^3+_X(OH)^2)A_X yH^2O. The ZBS is denoted by structural formula Zn_5(OH)_8A nH_2O or Zn_3(OH)_4A_2 nH_2O. A composition for preventing hair loss and promoting hair growth contains nanohybrid complex as an active ingredient in which vitamin C is inserted between layers. The composition is used in the form of lotion, emulsion, cream, essence, or spray.
Abstract translation: 目的：提供一种用于预防脱发和促进含有维生素C的毛发生长的有机/无机纳米杂交复合物，以确保稳定性并缓慢释放维生素C.构成：将用于预防脱发和促进毛发生长的纳米杂交复合物插入金属盐 。 金属盐是金属双层或锌碱式盐（ZBS）的层状双重胡萝卜素（LDH）。 LDH由结构式（M ^ 2 + _（1-x）N ^ 3 + _X（OH）^ 2）A_X yH ^ 2O表示。 ZBS由结构式Zn_5（OH）_8AnH_2O或Zn_3（OH）_4A_2nH_2O表示。 用于预防脱发和促进毛发生长的组合物包含纳米杂交复合物作为维生素C插入层之间的活性成分。 该组合物以洗剂，乳液，霜剂，精华液或喷雾剂的形式使用。
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Patent Agency Ranking
公开(公告)号：KR100937205B1
公开(公告)日：2010-01-19
申请号：KR1020070073442
申请日：2007-07-23
Applicant: (주)씨앤팜
IPC: A61K9/18 , A61K9/14 , A61K31/164
Abstract: 본 발명은 활성성분이 생체 친화성 공중합 고분자 계면활성제의 미셀 중에 담지된 활성성분-미셀의 복합체가 메조 다공성 무기 구조체의 동공 중에 혼성화된 혼성물질, 그 제조방법, 및 그 혼성물질을 포함하는 완제품을 제공한다.
메조 다공성 무기 구조체, 혼성 물질, 약물 전달체-
47.发明公开
公开(公告)号：KR1020090113772A
公开(公告)日：2009-11-02
申请号：KR1020090036226
申请日：2009-04-24
Applicant: (주)씨앤팜
CPC classification number: A61K47/24 , A61K9/0024 , C07F9/65815
Abstract: PURPOSE: A dendritic oligopeptide-grafted cyclotriphosphazene is provided to form hydrogel in low concentration and use as a drug carrier for transfer a protein drug. CONSTITUTION: A drug carrier with sustained release to drug contains dendritic oligopeptide-grafted cyclotriphosphazene of the chemical formula 1. The drug carrier is used for delivering protein drug or peptide drug. A method for preparing the dendritic oligopeptide-grafted cyclotriphosphazene comprises a step of reacting cyclotriphosphazene containing chlorine and polyethyleneglycol of the chemical formula 5 with ester of branched tetrapeptide of the chemical formula 6.
Abstract translation: 目的：提供树突寡聚肽接枝的环三磷腈以形成低浓度的水凝胶，并用作转运蛋白质药物的药物载体。 构成：具有药物持续释放的药物载体含有化学式1的树突寡聚肽接枝的环三磷腈。药物载体用于递送蛋白质药物或肽药物。 制备树枝状寡肽接枝的环三磷腈的方法包括使化学式5的含氯和聚乙二醇的环三磷腈与化学式6的支链四肽的酯反应的步骤。
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公开(公告)号：KR1020060093240A
公开(公告)日：2006-08-24
申请号：KR1020050014273
申请日：2005-02-21
Applicant: (주)씨앤팜
IPC: A61K47/48
CPC classification number: A61K31/4525 , A61K9/1611 , A61K9/1635 , A61K31/137 , A61K31/445 , A61K47/50
Abstract: 본 발명은 난용성 염기형 약물과 층상형 규산염간의 하이브리드 물질에 수용성 염기 폴리머가 첨가된 혼성체의 약학적 조성 및 그 제조방법에 관한 것이다. 상기 수용성 고분자로는 아미노알킬메타크릴레이트 공중합체(예를들어, 데구사(Degussa)의 유드라지트 E 100(Eudragit E 100: poly(butyl methacrylate, (2-dimethyl aminoethyl)methacrylate, methyl methacrylate) 1:2:1) 또는 폴리비닐아세탈 디에틸아미노아세테이트(AEA)등을 사용할 수 있다.
본 발명에 따르면 경구용 제제의 원료로 사용되는 유-무기 하이브리드 물질에서의 난용성 약물의 용출률을 단시간 내에 90% 가까이 높여 체내 흡수율에 대한 효율성을 높이는데 유용하다.-
公开(公告)号：KR100523525B1
公开(公告)日：2005-10-25
申请号：KR1020020047318
申请日：2002-08-10
Applicant: (주)씨앤팜
Abstract: 본 발명은 안정성과 서방성이 우수하고 부작용이 적은 약물 전달 시스템으로서 3-벤조일-α-메틸벤젠아세트산, 4-비페닐아세트산, 및 미노시클린으로 이루어진 군으로부터 선택된 약물과 층상 무기 물질의 혼성 물질을 제공한다.
또한, 본 발명은 약물의 특성에 따라 공침법 및 이온교환법을 이용한 상기 혼성 물질의 제조 방법을 제공한다. 혼성 물질의 제조 후 그 표면을 코팅하는 단계를 더 포함할 수 있다.
또한, 본 발명은 상기 혼성 물질을 포함하는 약학 조성물을 제공한다.
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