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公开(公告)号：KR102096629B1
公开(公告)日：2020-04-03
申请号：KR1020180084217
申请日：2018-07-19
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C12Q1/689 , C12Q1/6893 , C12Q1/6895
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公开(公告)号：KR101329349B1
公开(公告)日：2013-11-15
申请号：KR1020110100569
申请日：2011-10-04
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: 본 발명은 중탄산염을 포함하는 염소 흔들이병 치료용 약학적 조성물에 관한 것이다.
본 발명의 중탄산염을 포함하는 염소 흔들이병 치료용 약학적 조성물은 염소 흔들이병에 걸린 염소의 치료에 탁월한 효과를 가지며, 또한 이를 경구적으로 염소에 투여함으로써 집단사육을 하는 염소에 대해 투약이 용이하므로 산업상 이용가능성이 있다.-
公开(公告)号：KR101149872B1
公开(公告)日：2012-06-27
申请号：KR1020090028760
申请日：2009-04-03
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K39/112 , C12N5/07 , A61K39/10 , A61P37/00
Abstract: 본 발명은 병원균의 약독화 방법에 관한 것으로, 보다 자세하게는 병원균과 호중구를 공동 배양함으로써 상기 병원균을 약독화시키는 방법, 이렇게 약독화된 병원균 변이주 및 상기 변이주를 함유하는 백신 조성물에 관한 것이다.
병원균, 살모넬라, 호중구, 약독화-
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公开(公告)号：KR1020100110434A
公开(公告)日：2010-10-13
申请号：KR1020090028760
申请日：2009-04-03
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K39/112 , C12N5/07 , A61K39/10 , A61P37/00
CPC classification number: A61K39/0275 , A61K2039/522
Abstract: PURPOSE: A method for attenuating pathogen by co-culture of pathogen and neutrophil is provided to attenuate without high technology and safely apply to human body. CONSTITUTION: A pathogen is attenuated by co-culture of pathogen and neutrophils. The neutrophil is isolated from poultry, pig, lamb, horse, cat, dog or human. A method for co-culture of pathogen and neutrophil comprises: a step of co-culture of neutrophili and pathogen for 10 minutes to two hours; a step of killing pathogen; and a step of collecting and dissolving neutrophil. The attenuated pathogen is ST31-N5th-1(KACC 91447P) or ST31-N20th-B10th-12(KACC 91448P). A vaccine composition contains attenuated pathogenic mutant.
Abstract translation: 目的：通过病原体和嗜中性粒细胞的共培养来减轻病原体的方法，无需高技术的减毒，安全应用于人体。 构成：通过病原体和嗜中性粒细胞的共培养来减轻病原体。 嗜中性粒细胞与家禽，猪，羊，马，猫，狗或人类分离。 病原体和嗜中性粒细胞的共培养方法包括：将嗜中性粒细胞和病原体共培养10分钟至2小时的步骤; 杀死病原体的一个步骤; 和收集和溶解嗜中性粒细胞的步骤。 减毒病原体是ST31-N5th-1（KACC91447P）或ST31-N20th-B10th-12（KACC91448P）。 疫苗组合物含有减毒致病突变体。
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Patent Agency Ranking46.发明授权면역특이단백질 항원을 사용하는 우결핵 특이 효소면역진단키트 및 이를 이용한 우결핵 진단방법 有权包含免疫特异性蛋白质抗原和其他免疫原的牛结核特异性酶免疫测定试剂盒及其使用相同的牛结核病诊断方法
公开(公告)号：KR100951057B1
公开(公告)日：2010-04-07
申请号：KR1020070118743
申请日：2007-11-20
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: 본 발명은 우결핵 특이 효소면역진단 키트 및 이를 이용한 우결핵 진단방법에 관한 것으로, 보다 상세하게는 우결핵균의 단백질항원 중 면역특이단백질 항원인 MPB70 등을 이용한 효소면역측정법을 통하여 신속하고 정확하게 우결핵을 진단하는 우결핵 특이 효소면역진단 키트 및 이를 이용한 우결핵 진단방법에 관한 것이다.
우결핵, 정제단백질, 효소면역측정법, 피내검사-
47.发明公开동물의 면역능을 증강시키는 벌나무가지 추출물 및 이를함유하는 면역증강제 无效用于改善动物免疫的ACER TEGMENTOSUM MAXIM RAMULUS的提取物和用于改善含有其的免疫的试剂
公开(公告)号：KR1020090021610A
公开(公告)日：2009-03-04
申请号：KR1020070086250
申请日：2007-08-27
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: Provided is an immunity improver using acer tegmentosum maximowocz extract which improves a function of a nonspecific defense against pathogen and increases activity of animal immunocytes such as neutrophil and macrophages. An immunity improver using acer tegmentosum maximowocz extract comprises acer tegmentosum maximowocz extract as an active ingredient. A method for preparing the acer tegmentosum maximowocz extract includes a step of extracting the extract from the dried acer tegmentosum maximowocz at a temperature of 90~100°C by hot distilled-water.
Abstract translation: 本发明提供了一种免疫改良剂，其使用宏碁提取物，其改善对病原体的非特异性防御的功能，并增加动物免疫细胞如嗜中性粒细胞和巨噬细胞的活性。 使用槭树提取物的抗微生物改良剂作为活性成分。 本发明提供了一种用于制备尖角果胶提取物的方法，其特征在于，在90〜100℃的温度下，通过热蒸馏水从干燥的青蒿中提取提取物。
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公开(公告)号：KR1020090013599A
公开(公告)日：2009-02-05
申请号：KR1020070077854
申请日：2007-08-02
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K39/02 , A61P37/02 , A61K39/085
CPC classification number: A61K39/05 , C12R1/47 , Y10S435/887 , Y10S514/885
Abstract: An immunostimulant containing the lystic extract of Streptomyces albus is provided to reinforce the functions of various immune cells having the major role in the disease defense, thereby increasing the specific and nonspecific resistance to the disease infection of animals. The immunostimulant contains the lystic extract of Streptomyces albus which is prepared by cultivating Streptomyces albus in yeast malt extract agar broth at 26 deg. C for 72 hours, centrifuging the cultured fluid at 3000Xg for 30 minutes and collecting it, rinsing the collected pellet with phosphate buffered saline(PBS) of pH 7.2 and suspending the rinsed pellet in PBS, adding 5% of TNT solution containing 50mM of Tris-HCl, 0.15M of NaCl and 4% Triton x-114 as solubilizing agent into the Streptomyces albus suspension, stirring the mixture at room temperature for 2-3 days to solubilize the Streptomyces albus, and regulating pH of the solution to 6.5-7.2, and drying the solution in the thermostatic chamber.
Abstract translation: 提供含有链霉菌（Streptomyces albus）的提取物的免疫刺激剂，以增强在疾病防御中具有主要作用的各种免疫细胞的功能，从而增加对动物疾病感染的特异性和非特异性抗性。 免疫刺激剂含有通过在26度的酵母麦芽提取物琼脂培养基中培养链霉菌（Streptomyces albus）而制备的链霉菌链霉菌的提取物。 培养72小时，将培养液以3000Xg离心30分钟并收集，用pH7.2的磷酸盐缓冲盐水（PBS）冲洗收集的沉淀物，并将漂洗的沉淀悬浮于PBS中，加入5％含有50mM Tris -HCl，0.15M NaCl和4％Triton x-114作为增溶剂加入到Streptomyces albus悬浮液中，在室温下搅拌混合物2-3天以溶解链霉菌，并将溶液的pH调节至6.5-7.2 ，并干燥恒温室中的溶液。
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公开(公告)号：KR1020090004023A
公开(公告)日：2009-01-12
申请号：KR1020070067899
申请日：2007-07-06
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: G01N33/569 , G01N33/53
Abstract: A method for diagnosing the infection of vancomycin-resistant Enterococcus is provided to allow whether vancomycin-resistant Enterococcus is infected or not rapidly and effectively. A method for diagnosing the infection of vancomycin-resistant Enterococcus uses the antigen-antibody reaction with the specific antigen of vancomycin-resistant Enterococcus. Preferably the vancomycin-resistant Enterococcus is any one selected from Vancomycin-resistant Enterococcus phythium (VREFM), Vancomycin-resistant Enterococcus faecalis (VREFS), Vancomycin-resistant Enterococcus gallinarum (VREG), and Vancomycin-resistant Enterococcus casseliflavus.
Abstract translation: 提供了用于诊断耐万古霉素肠球菌感染的方法，以使万古霉素耐药肠球菌感染或不迅速有效地感染。 用于诊断耐万古霉素肠球菌的感染的方法使用与万古霉素耐药性肠球菌的特异性抗原的抗原 - 抗体反应。 优选地，万古霉素耐药性肠球菌是选自万古霉素耐药性肠球菌（VREFM），万古霉素耐药性粪肠球菌（VREFS），万古霉素耐药性肠球菌（VREG）和万古霉素耐药性肠球菌的任何一种。
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公开(公告)号：KR1020080092007A
公开(公告)日：2008-10-15
申请号：KR1020070035257
申请日：2007-04-10
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K36/804 , A61P17/00
CPC classification number: Y02A50/471
Abstract: An extract of Rehmannia glutinosa is provided to increase various activities of neutrophil or macrophages and induce strong protectivity on attack inoculation of pathogenic bacteria, thereby being used as an immune enhancing agent, a vaccine adjuvant, an adjuvant therapeutic agent and a feed additive for an animal. An extract of Rehmannia glutinosa enhances immunity of an animal by increasing the activity of immunocyte such as neutrophil or macrophages. A method for preparing the extract of Rehmannia glutinosa comprises the steps of: (a) boiling dried Rehmannia glutinosa with distilled water to obtain the extract of Rehmannia glutinosa; (b) filtering the extract; and (c) hydrolyzing a filtrate.
Abstract translation: 提供地黄提取物以增加嗜中性粒细胞或巨噬细胞的各种活性，并在致病细菌的侵袭接种中诱发强的保护作用，从而用作免疫增强剂，疫苗佐剂，佐剂治疗剂和用于动物的饲料添加剂 。 地黄提取物通过增加免疫细胞如嗜中性粒细胞或巨噬细胞的活性来增强动物的免疫力。 一种制备地黄提取物的方法，包括以下步骤：（a）用蒸馏水煮沸干燥的地黄，得到地黄提取物; （b）过滤提取物; 和（c）水解滤液。
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