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    세포내 타우 단백질의 상호작용을 모니터링하기 위한 이분자 형광 상보성 아미노산 서열 쌍
    41.
    发明公开
    세포내 타우 단백질의 상호작용을 모니터링하기 위한 이분자 형광 상보성 아미노산 서열 쌍 有权
    一对氨基酸序列，用于通过双分子荧光互补监测活细胞中的tau-tau相互作用

    公开(公告)号：KR1020150042308A

    公开(公告)日：2015-04-21

    申请号：KR1020130119898

    申请日：2013-10-08

    Applicant: 한국과학기술연구원

    Inventor： 김윤경 ,  김동진 ,  박기덕 ,  탁혜진 ,  레지스그레일 ,  민선준 ,  배애님 ,  김영수

    IPC: C07K14/47 ,  C12N15/12 ,  C12N15/63 ,  G01N33/53

    CPC classification number: C07K14/4711 ,  C07K2319/60 ,  C07K2319/70 ,  G01N33/6809 ,  C07K14/47 ,  C07K14/00 ,  C12N15/11 ,  C12N15/63 ,  G01N33/53

    Abstract: 본발명은살아있는세포내에서타우단백질사이의상호작용을모니터링하기위한단백질쌍, 이를암호화하는염기서열쌍, 이를포함하는벡터쌍, 상기벡터쌍에의해서형질전환된세포주, 및상기세포주를이용하여살아있는세포들에서타우-타우상호작용을모니터링하는방법에관한것으로서, 더욱구체적으로는, 세포내타우단백질의상호작용을모니터링하기위한이분자형광상보성아미노산서열쌍으로서, 전장인간타우아미노산서열의 C-말단에비너스아미노산서열의 N-말단서열이결합된제1 형광상보성아미노산서열; 및전장인간타우아미노산서열의 C-말단에비너스아미노산서열의 C-말단서열이결합된제2 형광상보성아미노산서열로이루어지는이분자형광상보성아미노산서열쌍, 이를암호화하는염기서열쌍, 이를포함하는벡터쌍, 상기벡터쌍에의해서형질전환된세포주및 상기세포주를이용하여살아있는세포들에서타우-타우상호작용을모니터링하는방법에관한것이다. 본발명에따르면, 살아있는세포들에서타우-타우상호작용을직접적으로가시화할수 있게함으로써타우올리고머화과정을모니터링하고정량할수 있으며, 따라서타우가관여하는질병의발생을연구하고그 올리고머화과정을방지하고되돌리기위한방법을개발하는데있어서유용한수단으로활용될수 있다.

    Abstract translation: 本发明涉及一种用于监测活细胞中tau蛋白之间的相互作用的蛋白质对，编码它们的碱基序列对，包含其的载体对，由载体对转化的细胞系以及用于监测tau-tau的方法 更具体地说，涉及用于监测细胞内tau蛋白相互作用的双分子荧光互补氨基酸序列对，编码它们的碱基序列，包含它们的载体对，由其转化的细胞系 载体对，以及使用细胞系监测活细胞中tau-tau相互作用的方法，其中双分子荧光互补氨基酸序列对由第一荧光互补氨基酸序列组成，其中金星氨基的N-末端序列 酸序列与全长人tau氨基酸序列的C-末端结合; 和第二荧光互补氨基酸序列，其中金星氨基酸序列的C-末端序列与全长人tau氨基酸序列的C-末端结合。 本发明可以通过直接观察活细胞中的tau-tau相互作用来监测和定量tau寡聚化过程，因此可以用作研究tau相关疾病的发生的有用手段，并开发一种预防和逆转的方法 低聚过程。

    산화질소 생성 억제용 피라졸로피리미딘 유도체 화합물
    43.
    发明公开
    산화질소 생성 억제용 피라졸로피리미딘 유도체 화합물 有权
    吡唑并嘧啶衍生物，抑制生产氮氧化物的组合物和药物组合物，用于预防和治疗包括其的疾病

    公开(公告)号：KR1020130112248A

    公开(公告)日：2013-10-14

    申请号：KR1020120034483

    申请日：2012-04-03

    Applicant: 한국과학기술연구원 ,  울산대학교 산학협력단

    Inventor： 정찬성 ,  김동진 ,  박기덕 ,  김윤경 ,  표정인 ,  김현태 ,  황온유 ,  아쉬라 ,  송치만 ,  김영수

    IPC: C07D487/04 ,  A61K31/519 ,  A61P25/00

    Abstract: PURPOSE: A composition containing a pyrazolopyrimidine derivative compound for suppressing NO generation and a pharmaceutical composition containing the pyrazolopyrimidine derivative compound for preventing and treating neurological disorders are provided to suppress NO generation in vivo and to treat neurological disorders caused by functional disturbance and apoptosis of neural cells. CONSTITUTION: A pyrazolopyrimidine derivative compound of chemical formulas I-VII or a pharmaceutically acceptable salt thereof is provided. A pharmaceutical composition for suppressing NO generation contains a pharmaceutically acceptable carrier or diluent and the compounds as active ingredients. A composition for treating neurological disorders contains the pharmaceutically acceptable carrier or diluent and the compounds as active ingredients. The neurological diseases are selected among Parkinson's disease, Alzheimer's disease, Huntington's disease, amylotrophic lateral sclerosis, epilepsia, depression, pain, anxiety, and neurodegenerative diseases.

    Abstract translation: 目的：提供含有用于抑制NO产生的吡唑并嘧啶衍生物化合物和含有吡唑并嘧啶衍生物化合物用于预防和治疗神经障碍的药物组合物，用于抑制体内NO产生并治疗由神经细胞的功能紊乱和细胞凋亡引起的神经障碍 。 构成：提供化学式I-VII的吡唑并嘧啶衍生物化合物或其药学上可接受的盐。 用于抑制NO生成的药物组合物含有药学上可接受的载体或稀释剂，作为活性成分的化合物。 用于治疗神经障碍的组合物含有药学上可接受的载体或稀释剂，并且所述化合物作为活性成分。 神经系统疾病选自帕金森病，阿尔茨海默病，亨廷顿病，肌营养性侧索硬化，癫痫，抑郁，疼痛，焦虑和神经变性疾病。

    마이크로 프로브 및 그 제조 방법
    44.
    发明公开
    마이크로 프로브 및 그 제조 방법 有权
    微探针及其制造方法

    公开(公告)号：KR1020130052157A

    公开(公告)日：2013-05-22

    申请号：KR1020110117435

    申请日：2011-11-11

    Applicant: 한국과학기술연구원

    Inventor： 조일주 ,  윤의성 ,  조제원 ,  전명건 ,  김윤경

    IPC: A61N1/05 ,  A61B5/0478 ,  H05K3/10

    CPC classification number: A61B5/0478 ,  A61B5/6868 ,  A61B2503/40 ,  A61B2503/42 ,  A61B2562/125 ,  A61B2562/18

    Abstract: PURPOSE: A microprobe and a manufacturing method thereof are provided to have an effect of maintaining the insertion strength of a microprobe which is probed in a brain by using an operation unit which is coated on a flexible unit of a probe. CONSTITUTION: A microprobe(100) includes a probing unit(110) which is composed of a strengthened material and inserted into a brain; a flexible unit(120) which is composed of a soft material and connected with the end of the probing unit; an operation unit(130) which is coated on at least one side of the flexible unit and composed of a material which is melted with a solution of the inside of a skull; and a body unit(140) which is connected with the other end of the flexible unit border whose one end is connected to the probing unit. A microprobe makes a feature in which the operation unit, which passes through an opening on a part of the skull and maintains the insertion strength after the probing unit is inserted into a brain, is melted by a solution of the inside of the skull; the flexible unit is exposed; and the body unit is used by being arranged on the outside of the skull.

    Abstract translation: 目的：提供一种微探针及其制造方法，其具有通过使用涂覆在探针的柔性单元上的操作单元来保持在脑中探测的微探针的插入强度的效果。 构成：微探针（100）包括探测单元（110），其由强化材料构成并插入脑中; 柔性单元（120），其由软质材料构成并与探测单元的端部连接; 操作单元（130），其被涂覆在柔性单元的至少一侧并且由用颅骨内部的溶液熔化的材料构成; 以及与柔性单元边界的另一端连接的主体单元（140），其一端连接到探测单元。 微探针具有这样的特征，其中通过颅骨的一部分上的开口并将探测单元插入大脑后保持插入强度的操作单元通过颅骨内部的溶液熔化; 柔性单元暴露; 并且通过布置在颅骨的外侧使用身体单元。

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