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公开(公告)号：KR1020100044612A
公开(公告)日：2010-04-30
申请号：KR1020080103817
申请日：2008-10-22
CPC classification number: C07K14/47 , C12Q1/6883 , C12Q2600/158 , C40B40/08 , C12Q1/6844 , C12Q2600/106 , G01N33/53
Abstract: PURPOSE: A specific gene MMH1(mus musculus heart 1) specifically developing at a heart tissue of a mouse is provided to reduce a false positive from a diagnosis research of heart related disease and to enable an easier diagnosis of the heart related disease. CONSTITUTION: A specific gene MMH1 specifically developing at a heart tissue is formed with an amino acid sequence. A micro array to diagnose heart related disease comprises the MMH1 gene. The micro array comprises an antibody at the MMH1 gene. A kit to diagnose the heart related disease comprises a primer set and a reagent for RT-PCR(reverse transcriptase polymerase chain reaction). The diagnosing method of the heart related disease of a mammal comprises a step of separating the total RNA from a mammal sample, a step of amplifying the target sequence by performing RT-PCR using the primer set, and a step of detecting a result subject.
Abstract translation: 目的：提供在小鼠心脏组织中特异性发育的特异性基因MMH1（mus musculus heart 1），以减少心脏相关疾病的诊断研究中的假阳性，并且能够更容易地诊断心脏相关疾病。 构成：用氨基酸序列形成在心脏组织中特异性发育的特异性基因MMH1。 用于诊断心脏病的微阵列包括MMH1基因。 微阵列包含MMH1基因上的抗体。 用于诊断心脏相关疾病的试剂盒包括引物组和用于RT-PCR（逆转录聚合酶链反应）的试剂。 哺乳动物心脏相关疾病的诊断方法包括从哺乳动物样品中分离总RNA的步骤，通过使用引物组进行RT-PCR扩增靶序列的步骤和检测结果对象的步骤。
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公开(公告)号：KR1020100009151A
公开(公告)日：2010-01-27
申请号：KR1020080069892
申请日：2008-07-18
IPC: A61K36/78 , A61K36/539 , A61P19/10
CPC classification number: A61K36/539 , A61K36/78 , A61K2300/00
Abstract: PURPOSE: A composition containing mixture extract of Saururus chinensis and Scutellaria baicalensis is provided to suppress osteoclast differentiation, enhance bone density and bone content, and prevent or treat osteoporosis. CONSTITUTION: A pharmaceutical composition for preventing or treating osteoporosis contains mixture extract of Saururus chinensis and Scutellaria baicalensis as an active ingredient. The weight ratio of the Saururus chinensis and Scutellaria baicalensis is 1:10-10:1. A food composition for preventing and relieving osteoporosis contains mixture extract of Saururus chinensis and Scutellaria baicalensis as an active ingredient. A method for producing the mixture extract comprises: a step of washing Saururus chinensis and Scutellaria baicalensis with water and drying; a step of extracting the Saururus chinensis and Scutellaria baicalensis with solvent; a step of cooling the extract at room temperature and filtering; a step of decompress-concentrating and freeze-drying; and a step of mixing the extract of Saururus chinensis and Scutellaria baicalensis.
Abstract translation: 目的：提供含有Saururus chinensis和黄芩的混合物提取物的组合物，以抑制破骨细胞分化，增强骨密度和骨含量，并预防或治疗骨质疏松症。 构成：用于预防或治疗骨质疏松症的药物组合物含有中华黄牛和黄芩的混合物提取物作为活性成分。 中华黄牛和黄芩的重量比为1:10-10:1。 用于预防和缓解骨质疏松症的食物组合物含有中华黄芪和黄芩的混合物提取物作为活性成分。 制备混合物提取物的方法包括：用水洗涤中华黄芩和黄芩的步骤; 用溶剂萃取中华黄龙和黄芩的一步; 在室温下冷却提取物并过滤的步骤; 减压浓缩和冷冻干燥步骤; 并将中国黄芪和黄芩提取物混合在一起。
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公开(公告)号：KR1020090064823A
公开(公告)日：2009-06-22
申请号：KR1020070132164
申请日：2007-12-17
IPC: A61K36/185 , A61P9/08 , A61P9/12
Abstract: A composition for relaxing blood vessel which contains an Ulmus macrocarpa extract prevent and treat various cardiovascular diseases by inducing the relaxation of vascular smooth muscle. A pharmaceutical composition for relaxing blood vessel contains an Ulmus macrocarpa extract as an active ingredient. The composition is effective in preventing and treating hypertension, coronary artery disease, cerebrovascular disease, peripheral vascular disease, main artery disease, kidney dysfunction, cardiac insufficiency or vision disorder An organic solvent for extracting the Ulmus macrocarpa is selected from ethanol, ethanol solution, methanol, methanol solution, butanol, dichloromethane, ethyl acetate, hexane and their mixture. A health food having the effect of blood vessel relaxation contains Ulmus macrocarpa extract.
Abstract translation: 用于放松血管的组合物含有榆木提取物通过诱导血管平滑肌的松弛来预防和治疗各种心血管疾病。 用于放松血管的药物组合物含有榆木大pa提取物作为活性成分。 该组合物有效预防和治疗高血压，冠状动脉疾病，脑血管疾病，外周血管疾病，主动脉疾病，肾功能不全，心功能不全或视力障碍。用于提取榆树的有机溶剂选自乙醇，乙醇溶液，甲醇 ，甲醇溶液，丁醇，二氯甲烷，乙酸乙酯，己烷及其混合物。 具有血管松弛作用的保健食品包含榆树提取物。
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44.发明授权３－하이드록시－３－메틸글루타릴 보조효소 Ａ 환원효소의저해제 및 고콜레스테롤로 인한 심장 질환 및 심혈관계질환 치료제 失效用于HMG-COA还原的竞争性抑制剂和治疗由高胆固醇引起的心脏病和心血管疾病
公开(公告)号：KR100847750B1
公开(公告)日：2008-07-22
申请号：KR1020070011206
申请日：2007-02-02
Applicant: 한국식품연구원
Abstract: A competitive inhibitor of HMG-CoA(3-hydroxy-3-methylglutaryl coenzyme A) reductase is provided to inhibit synthesis of cholesterol by inhibiting activity of HMG-CoA reductase, so that the compound is useful for treatment of cardiac and cardiovascular diseases caused by hypercholesterol. A peptide for competitively inhibiting the activity of HMG-CoA reductase has the amino acid sequence of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 or SEQ ID NO:4. A competitive inhibitor for HMG-CoA reductase contains the peptide of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 or SEQ ID NO:4. A therapeutic drug of cardiac and cardiovascular disease caused by hypercholesterol selected from hyperlipidemia, arteriosclerosis, hypertension, myocardial infarction, angina pectoris, cerebral apoplexy, cerebral hemorrhage and peripheral vascular disease contains the peptide of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 or SEQ ID NO:4.
Abstract translation: 提供HMG-CoA（3-羟基-3-甲基戊二酰辅酶A）还原酶的竞争性抑制剂，通过抑制HMG-CoA还原酶的活性来抑制胆固醇的合成，使得该化合物可用于治疗由 高胆固醇。 用于竞争性抑制HMG-CoA还原酶活性的肽具有SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3或SEQ ID NO：4的氨基酸序列。 HMG-CoA还原酶的竞争性抑制剂含有SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3或SEQ ID NO：4的肽。 选自高脂血症，动脉硬化，高血压，心肌梗塞，心绞痛，脑中风，脑出血和外周血管疾病的高胆固醇引起的心脏和心血管疾病的治疗药物含有SEQ ID NO：1，SEQ ID NO：2， SEQ ID NO：3或SEQ ID NO：4。
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公开(公告)号：KR1020080064238A
公开(公告)日：2008-07-09
申请号：KR1020070000902
申请日：2007-01-04
CPC classification number: A61K36/78 , A23L2/38 , A23L33/105 , A23V2002/00 , A61K31/065 , A61K31/36 , A23V2200/326 , A23V2250/21
Abstract: A composition comprising a root extract of Saururus chinensis or a compound isolated from the extract is provided to show excellent blood pressure lowering effect through vascular relaxation, thereby being usefully used as a pharmaceutical composition or a health food composition for preventing and treating various cardiovascular diseases caused by hypertension and complications of the hypertension. A pharmaceutical composition for vascular relaxation comprises a compound selected from the group consisting of machilin D, saucerneol D and a mixture thereof or a root extract of Saururus chinensis comprising the same compound as an effective ingredient, wherein the extract is prepared by using an organic solvent selected from the group consisting of ethanol, an aqueous solution of the ethanol, methanol, an aqueous solution of the methanol, butanol. dichloromethane, ethylacetate, hexane and a mixture thereof.
Abstract translation: 提供了包含中华鲟的根提取物或从提取物中分离的化合物的组合物，以通过血管松弛显示优异的降血压效果，从而有效地用作预防和治疗引起的各种心血管疾病的药物组合物或保健食品组合物 通过高血压和并发症的高血压。 用于血管松弛的药物组合物包含选自机体D，香草醇D及其混合物的化合物或包含与有效成分相同的化合物的中华黄瓜的根提取物，其中所述提取物通过使用有机溶剂 选自乙醇，乙醇水溶液，甲醇，甲醇水溶液，丁醇组成的组。 二氯甲烷，乙酸乙酯，己烷及其混合物。
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Patent Agency Ranking46.发明授权삼백초 추출물 또는 이로부터 분리된 활성 화합물을포함하는 골다공증 예방 또는 치료용 조성물 有权用于预防或治疗包含SAURURUS CHINENSIS或活性化合物提取物的OSTEOPOSOSIS的组合物，其分离
公开(公告)号：KR100833654B1
公开(公告)日：2008-05-29
申请号：KR1020070013661
申请日：2007-02-09
IPC: A61K36/78 , A61P19/10 , A61K31/341
CPC classification number: A61K36/78
Abstract: A composition comprising the extract of Saururus chinensis or active compounds isolated therefrom is provided to inhibit growth of osteoclast, so that the composition is useful for preventing or treating osteoporosis. A composition for preventing or treating osteoporosis comprises 0.01-30 wt.% of the extract of Saururus chinensis, which is prepared by extracting Saururus chinensis with C1-4 alcohol and its solution, dichloromethane, ethylacetate or a mixture thereof, or active compounds isolated from the Saururus chinensis extract including (-)-saucerneol represented by the formula(1) and sauristolactam represented by the formula(2), and is a pharmaceutical or health food composition having a formulation of beverage.
Abstract translation: 提供了包含中华黄牛提取物或从其分离的活性化合物的组合物以抑制破骨细胞的生长，使得该组合物可用于预防或治疗骨质疏松症。 用于预防或治疗骨质疏松症的组合物包括通过用C 1-4醇提取中华黄芪和其溶液，二氯甲烷，乙酸乙酯或其混合物或从其中分离的活性化合物制备的中华黄瓜提取物的0.01-30重量％ 含有由式（1）表示的（ - ） - 三氯蔗糖和由式（2）表示的沙拉耳内酰胺，是具有饮料配方的药物或保健食品组合物。
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47.发明授权ＢＡＣＥ-1의 활성을 저해하는 파고지 종자 추출물 또는이로부터 분리된 활성물질을 포함하는 퇴행성 뇌질환의예방 또는 치료용 조성물 有权用于预防或治疗包含来自一种PSORALEA CORYLIFOLIA的一种提取物的神经变性疾病的组合物抑制BACE-1或其活性成分的活性
公开(公告)号：KR100833652B1
公开(公告)日：2008-05-29
申请号：KR1020060136696
申请日：2006-12-28
IPC: C07D407/04
Abstract: A composition comprising the extract of Psoralea corylifolia seed or effective compounds contained therein is provided to inhibit the activity of BACE-1(beta-site APP(amyloid precursor protein)-cleaving enzyme 1) mediating the formation of beta-amyloid as a main causing material of dementia, so that the composition is useful for preventing or treating neurodegenerative disease. A composition for preventing or treating neurodegenerative disease comprises the extract of Psoralea corylifolia seed, which is prepared by extracting Psoralea corylifolia seeds with C1-4 alcohol or its solution, dichloromethane, ethylacetate or a mixture thereof, or a compound selected from 7-hydroxy-3-(4-methyl-4-(4-methylpentene-3-yl)-4H-chromen-6-yl)-4H-chromen-4-one represented by the formula(1), bakuchiol, bavachromene, isobavachromene, bavachalcone, isobavachalcone, bavachinin, 7,8-dihydro-8-(4-hydrophenyl)-2,2-dimethyl-2H,6H-[1,2-b:5,4-b']dipyran-6-one isolated from the extract of Psoralea corylifolia seed.
Abstract translation: 提供包含补骨脂素提取物或其中含有的有效化合物的组合物以抑制BACE-1（β-位点APP（淀粉样蛋白前体蛋白）切割酶1）的活性，其介导β-淀粉样蛋白的形成作为主要原因 因此该组合物可用于预防或治疗神经退行性疾病。 用于预防或治疗神经退行性疾病的组合物包括通过用C 1-4醇或其溶液，二氯甲烷，乙酸乙酯或其混合物或选自7-羟基-2-甲基苯酚的化合物提取茄科植物提取物的方法制备的补骨脂素提取物， 由式（1）表示的3-（4-甲基-4-（4-甲基戊烯-3-基）-4H-色烯-6-基）-4H-色烯-4-酮，苯甲酸，巴伐溴苯，异葎草酮，巴伐昔酮 ，异哈查酮，巴伐他丁，7,8-二氢-8-（4-氢苯基）-2,2-二甲基-2H，6H- [1,2-b：5,4-b']二吡喃-6-酮 茯苓提取物。
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公开(公告)号：KR100495568B1
公开(公告)日：2005-06-16
申请号：KR1020020048502
申请日：2002-08-16
IPC: A23L1/202
Abstract: 본 발명은 적어도 고추장과 공지의 조미성분을 함유하는 고추장 소스조성물에 있어서, 페이스트 상을 구성하는 주된 성분으로 토마토페이스트가 함유됨을 특징으로 하는 고추장 소스조성물 및 그 제조방법에 관한 것이다.
본 발명의 고추장 소스 제조방법은 고추장, 토마토페이스트 및 정제수를 균질화하여 고추장 페이스트를 제조하는 단계; 상기 고추장 페이스트에 전분 및 조미성분을 혼합하고 가열시켜 조미된 고추장 페이스트를 제조하는 단계; 및 상기 조미된 고추장 페이스트에 잔탄검질액, 물엿, 향신료 성분 및 식초를 첨가하는 단계를 포함한다.
상기 구성에 의한 고추장 소스는 독특한 풍미가 함유되어 있어서 지방질이 많은 육류나 피자와 같은 식품에 잘 조화될 뿐만 아니라, 살균처리시 장기 유통이 가능하고 소량의 단위포장이 가능하여 소비자가 쉽게 사용할 수 있다. 또한 본 발명의 고추장 소스는 체중감량 효과와 고혈압의 억제효과가 확인되고 있는 바와 같이 고풍미의 기능성 소스를 제공한다.-
公开(公告)号：KR1020170054628A
公开(公告)日：2017-05-18
申请号：KR1020150156844
申请日：2015-11-09
Applicant: 한국식품연구원
Abstract: 본개시는개인유전형및 표현형정보를고려한맞춤형식품정보추천시스템에있어서, 유전형정보, 표현형정보, 사용자식단정보중 적어도하나이상을포함하는사용자의개인정보가입력되는입력부; 전장유전체연관분석 (GWAS:genom wide association study) 정보및 음식정보가저장된저장부; 입력된유전형정보와전장유전체연관분석정보를이용하여유전형정보에따른비만위험도를계산하고, 표현형정보와음식정보를이용하여적어도하나의식단정보를만드는처리부; 그리고, 처리부에서계산된비만위험도및 처리부에서만든식단정보중 적어도하나이상을표시하는표시부;를포함하는것을특징으로하는개인유전형및 표현형정보를고려한맞춤형식품정보추천시스템에관한것이다.
Abstract translation: 本公开中的用户输入的个人信息输入包括根据考虑到个体基因型和表型信息，基因型信息，表型信息，用户信息饮食中的至少一个定制的信息推荐系统食品的; 全基因组关联研究（GWAS）信息和食物信息; 处理和计算肥胖的风险，通过使用表型信息和食品信息来创建根据基于输入的基因型信息和全长基因组关联分析信息的基因型信息的饮食中的至少一个的信息; 然后，肥胖的风险，以及用于显示的在处理单元计算出的处理创建的饮食信息的至少一个显示单元;涉及考虑个体基因型和表型信息，包括定制的食品信息推荐系统，包括：。
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公开(公告)号：KR101349140B1
公开(公告)日：2014-01-10
申请号：KR1020120009153
申请日：2012-01-30
Applicant: 한국식품연구원
Abstract: 본 발명은 돼지감자 및 청국장을 유효성분으로 포함하는 대사질환의 예방 또는 치료용 조성물을 제공한다. 본 발명의 조성물은 공복 혈당, 인슐린 저항성의 감소, 혈당 증가의 억제, 인슐린 분비능을 증가시킴으로써 당뇨병의 예방 및 치료에 뛰어난 효과를 나타낸다. 한편, 본 발명의 조성물은 중성지방의 간 축적을 감소시킴으로써 지방간의 예방 및 치료에 뛰어난 효과를 나타낸다. 또한, 본 발명은 돼지감자 및 청국장을 유효성분으로 포함하는 당뇨병 또는 지방간의 예방 또는 개선용 기능성 식품 조성물을 제공한다.
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