公开(公告)号：DE19544449A1

公开(公告)日：1997-06-05

申请号：DE19544449

申请日：1995-11-29

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  SANNER AXEL DR ,  DENZINGER WALTER ,  LANG SIEGFRIED DR

IPC: A61K47/48 ,  A01N59/12 ,  A61K31/00 ,  A61K31/755 ,  A61K31/787 ,  A61P1/00 ,  A61P1/12 ,  A61P31/00 ,  A61P31/04 ,  C08F8/18 ,  C08F8/20 ,  C08F8/22 ,  C08F26/06 ,  C08F226/06 ,  C08K3/02 ,  C08L39/04 ,  A61K31/415 ,  A61K31/505

Abstract: The invention concerns powdery complexes comprising iodine and a crosslinked polymer based on N-vinyl compounds and obtained by the dry heating of iodine and a polymer obtained by polymerizing monovinyl compounds (monomers A), of which the vinyl group is bonded to an N-atom of a nitrogenous heterocyclic ring, in the presence of between 0.5 and 10 wt %, relative to the monomers (A), of a compound (B) of general formula (I), A standing for -CH- or an N-atom and n being 2 or 3. The complexes are suitable for producing anti-diarrhoeal agents.

公开(公告)号：DE19539362A1

公开(公告)日：1997-04-24

申请号：DE19539362

申请日：1995-10-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  HAERTL AXEL PAUL DR ,  MAIER WERNER ,  ROSENBERG JOERG DR ,  SCHIESL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/24

Abstract: The invention concerns a method of producing medicaments in solid form by mixing and melting at least one pharmacologically acceptable polymer binder, at least one pharmaceutical active substance and optionally conventional pharmaceutical additives in the absence of a solvent to form a plastic mixture, and shaping this mixture to form the desired medicament, the mixing, melting and shaping steps being carried out continuously and separately. The method according to the invention enables high-quality medicaments to be produced in a simple and careful manner.

公开(公告)号：DE19511131A1

公开(公告)日：1996-10-02

申请号：DE19511131

申请日：1995-03-27

Applicant: BASF AG

Inventor： SPENGLER REINHARD DR ,  ROSENBERG JOERG DR ,  BREITENBACH JOERG DR

IPC: A61K9/28 ,  A61K9/16 ,  A61K9/24 ,  A61K31/485 ,  A61K31/60

Abstract: The invention concerns mechanically stable solid formulations of active substances, containing at least one active substance and at least one polymer and provided with a coating containing a proportion of softener equal to 0-16 wt. %. With the formulations of active substances proposed, it is possible to achieve mechanical stabilisation of moulded articles such as tablets, granules or pellets based on the above polymers when the latter are treated to produce solid solutions with the above active substances or when those polymers are treated with softening active substances such as acetylsalicylic acid, fenofibrate, naftidrofuryl, furosemide, ibuprofen, anipamil, benzoic acid, or indomethacin.

公开(公告)号：DE4446470A1

公开(公告)日：1996-06-27

申请号：DE4446470

申请日：1994-12-23

Applicant: BASF AG

Inventor： ROSENBERG JOERG DR ,  MAIER WERNER ,  FRICKE HELMUT DR ,  BREITENBACH JOERG DR

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: The present invention concerns a method of producing divisible tablets by melt calendering: two form cylinders are combined, one of the cylinders having at least one recess with at least one ridge which extends as far as the surface line of the cylinder and forms a break groove.

公开(公告)号：DE19642490A1

公开(公告)日：1998-04-16

申请号：DE19642490

申请日：1996-10-15

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  SCHADE CHRISTIAN DR ,  SIGWART CHRISTOPH DR ,  MUELLER ULRICH DR ,  HESSE MICHAEL DR ,  NEGELE ANTON DR ,  RUEBENACKER MARTIN DR ,  ELLER KARSTEN DR

IPC: C08F4/606 ,  C08F26/02 ,  C08F26/00 ,  A61K31/795

Abstract: Cationic polymerisation of N-vinylamides, optionally with comonomers, is initiated by a heterogeneous catalyst which is: (i) a carrier catalyst; (ii) an acid-activated layered silicate; (iii) a zeolite or silico-alumo-phosphate of zeolitic structure; (iv) a hetero-polyacid, or (v) a crosslinked polymer containing fluorosulphonic acid groups. The N-vinylamide is preferably N-vinyl pyrrolidone or a compound of formula (I) CH2=CH-N(COR )(R ) (I) R , R = H or 1-6C alkyl, especially N-vinyl formamide.

公开(公告)号：AT164606T

公开(公告)日：1998-04-15

申请号：AT95112007

申请日：1995-07-31

Applicant: BASF AG

Inventor： FISCH HERBERT DR ,  STEIN STEFAN DR ,  SANNER AXEL DR ,  SPERLING-VIETMEIER KARIN DR ,  BREITENBACH JOERG DR

IPC: A61K8/72 ,  A61K8/00 ,  A61K8/04 ,  A61K8/88 ,  A61Q5/00 ,  A61Q5/06 ,  C08G69/36 ,  C08G69/42 ,  C08J5/18 ,  C08L77/00 ,  A61K7/06

Abstract: The use of water-dispersible polyamides (I) contg. sulphonate gps. as film formers in hair-setting compsns. is new, where (I) are obtd. from a mixt. of: (a) 20-99 mole % of a 2-12C monoamino carboxylic acid or its lactam; (b) 0.5-40 mole % of a 2-18C diamine; (c) 0.5-25 mole % of a sulphonated 4-12C dicarboxylic acid; and (d) 0-35 mole % of a 2-16C dicarboxylic acid. Also claimed are: (1) an aq. hair-setting compsn. contg. a polymer as above as film former; (2) a polyamide as above where components (a)-(c) are present in amts. of 30-94.8, 2.6-37, 2.6-7 and 0-30 mole % resp.; and (3) aq. dispersions contg. 1-70 wt.% of a polyamide as in (2).

公开(公告)号：DE19641437A1

公开(公告)日：1998-04-09

申请号：DE19641437

申请日：1996-10-08

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  LANG SIEGFRIED DR ,  KRATZ DETLEF DR

IPC: C07D223/10 ,  A61K8/49 ,  A61K9/00 ,  A61K9/08 ,  A61K31/42 ,  A61K31/445 ,  A61K31/55 ,  A61K47/06 ,  A61K47/16 ,  A61K47/22 ,  A61Q19/00 ,  C07D207/26 ,  C07D207/263 ,  C07D207/267 ,  C07D207/27 ,  C07D211/40 ,  C07D211/76 ,  C07D227/087 ,  C07D263/18 ,  C07D265/28 ,  C07D265/32 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  A61K7/00

Abstract: The invention relates to 1,3-bis-(N-lactamyl) propane having general formula (I), wherein radicals R ,R ,R ,R ,R ,R , (NLac) and (NLac') have the meaning cited in the description, and the use thereof as a solvent in pharmaceutical and cosmetic agents.

公开(公告)号：DE19637479A1

公开(公告)日：1998-03-19

申请号：DE19637479

申请日：1996-09-13

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  KLEINKE ANDREAS DR

IPC: A61K9/20 ,  A61K9/16

Abstract: Preparation of solid pharmaceutical forms by mixing at least one polymeric binding material, at least one pharmaceutically active agent, and optionally usual pharmaceutical additives; extruding the mixture; and shaping into the required form. At least a part of the binding material is added in the form of an aqueous dispersion and/or solution.

公开(公告)号：DE19602206A1

公开(公告)日：1997-07-24

申请号：DE19602206

申请日：1996-01-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  ROSENBERG JOERG DR

IPC: A61K47/04 ,  A61K9/20 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K45/00 ,  A61K47/32 ,  A61P25/00 ,  A61P29/00 ,  A61K9/22

Abstract: The invention concerns preparation of non-steroidal analgesics with antipyretic and antiphlogistic effect, obtained through extrusion and moulding of a melt containing in addition one or more substances in a mixture of: a) 40 to 99.5 wt% of a homopolymer of N -vinylpyrrolidone with a K value according to Fikentscher of 30; b) 0.25 to 59.75 wt% of a water-soluble copolymer of N-vinylpyrr olidone; and c) 0.25 to 10 wt% of one or more physiologically ac ceptable sodium or potassium salts, where the quantities refer to the total of the components a), b) and c).

公开(公告)号：DE19539363A1

公开(公告)日：1997-04-24

申请号：DE19539363

申请日：1995-10-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  HAERTL AXEL PAUL DR ,  ROSENBERG JOERG DR ,  SCHIESL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61K9/20 ,  A61K9/22 ,  A61K9/16

Abstract: The invention concerns a method of producing medicaments in solid form by mixing and melting at least one pharmacologically acceptable polymer binder, at least one pharmaceutical active substance and optionally conventional pharmaceutical additives in the absence of a solvent to form a plastic mixture, and shaping the mixture to form the desired medicament, mixing and melting being carried out in separate stages. The method according to the invention enables high-quality medicaments to be produced in a simple and careful manner.