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公开(公告)号：JP2009000092A
公开(公告)日：2009-01-08
申请号：JP2007168030
申请日：2007-06-26
Inventor： YATANI TERU , FUJIMURA TSUTOMU
IPC: A01K67/027 , C12N15/09 , G01N33/50
Abstract: PROBLEM TO BE SOLVED: To provide a human photo aged skin model useful for evaluating cosmetics or the like in terms of anti-photoageing or improving effects, and to provide an animal model and a method for producing them. SOLUTION: The method for making the human photoaged skin model is the one where UV rays, having wavelengths B of 40 to 100 mJ/cm 2 , are continuously irradiated on the transplanted skin of an immunodeficient non-human animal transplanted with the human skin for 6 weeks or longer. The human photoaged skin model and the animal model are produced by the method. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation: 要解决的问题：提供一种用于评价化妆品等方面的抗光老化或改善效果的人类照片老化皮肤模型，并提供动物模型及其生产方法。 解决方案：用于制造人类皮肤皮肤模型的方法是具有40至100mJ / cm 2的波长B的UV射线在免疫缺陷的移植皮肤上连续照射的方法 非人类动物与人体皮肤移植6周或更长时间。 人造皮肤模型和动物模型通过该方法生产。 版权所有（C）2009，JPO＆INPIT
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公开(公告)号：JP2009000052A
公开(公告)日：2009-01-08
申请号：JP2007164425
申请日：2007-06-21
Inventor： YATANI TERU , FUJIMURA TSUTOMU
IPC: A01K67/027 , C12N15/09 , G01N33/50
Abstract: PROBLEM TO BE SOLVED: To provide a human photo aged skin model which is useful for evaluating cosmetics or the like in terms of anti-photoaging or improving effects, and to provide an animal model and a method for producing them.
SOLUTION: The method for making the human photo aged skin model is performed by continuously irradiating UV rays, having wavelengths B of 40 to 100 mJ/cm
2 , on the transplanted skin of an immunodeficient non-human animal transplanted with the human skin, for 6 weeks or longer. The human photo aged skin model and the animal model are produced by the method.
COPYRIGHT: (C)2009,JPO&INPITAbstract translation: 要解决的问题：提供一种用于评价化妆品等在抗光老化或改善效果方面的人类照片老化皮肤模型，并提供动物模型及其制备方法。 解决方案：人造皮肤老化皮肤模型的制备方法是通过连续照射波长为40〜100mJ / cm 2的SP的紫外线，在免疫缺陷型非皮肤移植皮肤上进行， 人体动物移植人体皮肤6周以上。 人类照片老化皮肤模型和动物模型通过该方法生产。 版权所有（C）2009，JPO＆INPIT
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公开(公告)号：JP2007167060A
公开(公告)日：2007-07-05
申请号：JP2006166376
申请日：2006-06-15
Inventor： YATANI TERU , FUJIMURA TSUTOMU
IPC: A01K67/027 , C12N5/06
CPC classification number: A01K67/0271 , A01K2227/105 , A01K2267/035
Abstract: PROBLEM TO BE SOLVED: To provide a photoaged model human skin and model animal each useful for evaluating effect of cosmetics to preventing and improving photoageing, etc., and to provide a method for preparing those. SOLUTION: The method for preparing the photoaged human skin comprises continuously irradiating ultraviolet light having 80-100 mJ/cm 2 B wavelength for 4-8 weeks to a transplanted skin of immunodeficient nonhuman animal to which human skin is transplanted and allow the irradiated skin to stand at least for three weeks after irradiation. The human photoageing model skin and the model animal are each prepared by the method. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 要解决的问题：提供一种用于评估化妆品对预防和改善光老化等的效果的人造皮肤和模型动物的光老化模型，并提供一种制备它们的方法。 解决方案：制备光老化人体皮肤的方法包括将具有80-100mJ / cm 2 SP波长的紫外线连续照射4-8周至免疫缺陷非人动物的移植皮肤，其中 移植人体皮肤，照射皮肤至少持续三周。 人类光老化模型皮肤和模型动物均通过该方法制备。 版权所有（C）2007，JPO＆INPIT
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公开(公告)号：JP2005206568A
公开(公告)日：2005-08-04
申请号：JP2004052276
申请日：2004-02-26
Inventor： FUJIMURA TSUTOMU
IPC: G01N33/50 , A61K8/00 , A61K8/96 , A61K8/97 , A61K45/00 , A61P17/16 , A61P43/00 , A61Q19/00 , G01N33/15
Abstract: PROBLEM TO BE SOLVED: To provide a skin aging preventing or ameliorating agent for preventing or ameliorating the aging of skin and a method for preventing or ameliorating aging of skin by clarifying the relationship between the aging and the force generated in a dermatic fibroblast cell which is a non-muscular cell and increasing the generation power of the cell.
SOLUTION: The agent for preventing or ameliorating the aging of skin contains an Rho kinase or an expression increasing substance for myosin light-chain kinase. Preferably, the Rho kinase or myosin light-chain kinase expression increasing substance of the skin aging preventing or ameliorating agent is a plant selected from Althaea officinalis, Curcuma longa, Actinidia chinensis, Gentiana lutea, Crataegus cuneata, Rehmannia glutinosa, Syzygium aromaticum, Calendula officinalis, Rose canina, Petroselinium sativum, Hamamelis virginiana, Asiasarum sieboldii, etc., or an extract of the plant.
COPYRIGHT: (C)2005,JPO&NCIPIAbstract translation: 要解决的问题：提供防止或改善皮肤老化的皮肤老化防止或改善剂，以及通过澄清老化和在皮肤成纤维细胞中产生的力之间的关系来预防或改善皮肤老化的方法 细胞，其是非肌肉细胞并增加细胞的发生能力。 解决方案：用于预防或改善皮肤老化的药剂含有肌球蛋白轻链激酶的Rho激酶或表达增加物质。 优选地，皮肤老化预防或改善剂的Rho激酶或肌球蛋白轻链激酶表达增加物质是选自以下药物的植物：阿尔卡氏菌，姜黄，猕猴桃，龙胆，山楂，地黄，金盏花 ，玫瑰canina，石斛，金缕梅，亚洲um ii等，或植物提取物。 版权所有（C）2005，JPO＆NCIPI
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公开(公告)号：JP2001278769A
公开(公告)日：2001-10-10
申请号：JP2000091398
申请日：2000-03-29
Applicant: KAO CORP
Inventor： FUJIMURA TSUTOMU , ENDO NAOKO
Abstract: PROBLEM TO BE SOLVED: To obtain a skin cosmetic which has a synergistically promoted skin- tightening effect and enhanced safety, improves the wrinkles and sagging of skins, and gives tensive and beautiful skins. SOLUTION: This skin cosmetic contains an integrin production-stimulating agent (one or more algae or plants selected from Fucus vesiclosus or Fucus evanescens, Laminaria japonika Areschoug, Hizikia fusiforme Okamura, Rosmarinus officinatis, Actinidia chinensis, Panax ginseng C. A. Meyer, Poria cocos Wolf, Prunus persica Batsch, and Arctium lappa L., or their extracts) and an actin-myosin-based activating agent (one or more plants selected from Scutellaria baicalensis Georgi, Phellodendron amurense Ruprecht, Gardenia jasminoides Ellis, Rehmannia glutinosa Liboschitz var. purpurea Makino, Zingiber officinale Roscoe and Astragalus sinicus, and their extracts).
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Patent Agency Ranking
公开(公告)号：JP2000026271A
公开(公告)日：2000-01-25
申请号：JP12166299
申请日：1999-04-28
Applicant: KAO CORP
Inventor： YADA YUKIHIRO , HIGUCHI KAZUHIKO , IMOKAWA GENJI , FUJIMURA TSUTOMU , OHASHI YUKIHIRO , KAWAMATA AKIRA
IPC: A61K8/30 , A61K8/00 , A61K8/41 , A61K8/68 , A61K9/06 , A61K31/00 , A61K31/13 , A61K31/133 , A61P17/00 , A61P17/16 , A61P43/00 , A61Q19/00 , A61K7/48 , A61K7/00
Abstract: PROBLEM TO BE SOLVED: To obtain the subject inhibitor capable of suppressing turnover sthenia of skin such as acanthosis, parakeratosis, abnormality of skin lipid metabolism, etc., caused by ultraviolet rays, etc., and normalizing skin keratinization by including a sphingosine. SOLUTION: This inhibitor contains a sphingosine (e.g. a compound of the formula or the like) being a physiologically active component existing in skin. The amount of the sphingosine formulated is, in the case of using the inhibitor as an emulsion-based external preparation for skin, 0.001-5 wt.%, and in the case of using an oily external preparation for skin comprising a liquid hydrocarbon such as squalane or the like, 0.01-10 wt.%. The sphingosine is obtained by extracting sphingolipid, etc., from a proper tissue (e.g. bovine brain or the like), hydrolyzing and extracting the hydrolyzate with an organic solvent.
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公开(公告)号：JPH11290315A
公开(公告)日：1999-10-26
申请号：JP9300998
申请日：1998-04-06
Applicant: KAO CORP
Inventor： FUJIMURA TSUTOMU , TSUKAHARA KAZUE , MORIWAKI SHIGERU , TAKEMA YOSHINORI
Abstract: PROBLEM TO BE SOLVED: To obtain high correlative relation with sensory evaluation and also to easily attain measurement by measuring the thickness of skin. SOLUTION: Skin consists of three layers, that is, a cuticle, a corium and a hypodermis. The total thickness of the three is measured and a skin stiffening effect is evaluated by the increase and decrease rate. It is favorable that the total thickness of the cuticle and the corium among them is measured since correlation with a skin stiffening feeling by human sense is high and, especially, the measurement of the thickness of the corium is favorable. Measurement is easily attained in vivo by a method for analyzing an image through the use of an ultrasonic wave measuring instrument as the one for measuring skin thickness and it is favorable as precision is high. The increase and decrease rate in skin thickness measured in this way is provided with high correlative relation with the skin stiffening feeling. The feeling is increased when skin becomes thinner and it is lost when skin becomes thick.
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公开(公告)号：JPH1095713A
公开(公告)日：1998-04-14
申请号：JP24978096
申请日：1996-09-20
Applicant: KAO CORP
Inventor： FUJIMURA TSUTOMU , TAKEMA YOSHINORI
Abstract: PROBLEM TO BE SOLVED: To conveniently and accurately evaluate improvement effect for slack of skin in vitro by measuring the strength of a specific substance which enhances the gel strength containing in a test sample. SOLUTION: This evaluation is to measure the strength of collagen gel filled up animal cells containing a test sample. As the animal cells, normal skin fibroblast, pulmonary fibroblast, gingival fibroblast, chondromatous cell, liver cell and vascular endothelial cell are illustrated. Among them, skin fibroblast and pulmonary fibroblast are particularly preferable. As the animals providing cells, human, mouse, rat and rabbit are preferable. As these cells, both of primary cultured cells and aged cells of which subculture is repeated in vitro may be used. In addition, either of cells arising from fetus and aged man may be also utilized. As collagens used here, collagens arising from human, mouse, rat, rabbit, guinea pig and cattle are preferable. As methods for measuring the strength of collagen gel, stress relaxation test, cutting test and creep test are illustrated.
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公开(公告)号：JPH1072336A
公开(公告)日：1998-03-17
申请号：JP14159897
申请日：1997-05-30
Applicant: KAO CORP
Inventor： FUJIMURA TSUTOMU , TSUKAHARA KAZUE , ITO NORIKO , TAKEMA YOSHINORI
IPC: A61K8/96 , A61K8/00 , A61K8/02 , A61K8/97 , A61K36/00 , A61K36/02 , A61K36/07 , A61K36/18 , A61K36/23 , A61K36/28 , A61K36/53 , A61K36/60 , A61K36/73 , A61K36/896 , A61P17/00 , A61Q19/00 , A61K7/48 , A61K7/00 , A61K35/78 , A61K35/80 , A61K35/84
Abstract: PROBLEM TO BE SOLVED: To obtain a collagen gel contraction accelerator having excellent improving effect on loosening of skin and tightening effect on skin. SOLUTION: Each of this collagen gel contraction accelerator, a composition for improving loosening of skin and a composition for tightening of skin, contains one or more than two kinds of plants or their extracts selected from Ginkgo biloba, Rhodophyceae, Fucales fucus, Matricaria chamomilla, Perilla frutescens var. acuta, Persica semen, Panax ginseng, Foeniculum vulgare, Morus bombycis, Gentiana lutea, Arctium lappa, Cortinellus shiitake, Allium sativum, Humulus lupulus, Paeonia suffruticosa, Saxifrage stolonifera, Lactuca sativa, Poria hoelen, Rosmarinus officinalis, Astragalus sinicus, Actinidia chinensis, Salvia officinalis and Filipendula multijuga as active components.
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公开(公告)号：JPH09202709A
公开(公告)日：1997-08-05
申请号：JP27462796
申请日：1996-10-17
Applicant: KAO CORP
Inventor： FUJIMURA TSUTOMU , OGAWA AYUMI , TSUKAHARA KAZUE , TAKEMA YOSHINORI , NAGAI MINORU , ONO TOSHIYA
IPC: C07H15/04 , A61K8/00 , A61K8/30 , A61K8/36 , A61K8/37 , A61K8/41 , A61K8/43 , A61K8/46 , A61K8/60 , A61K8/68 , A61Q19/00 , C07C279/08 , A61K7/00 , A61K7/48
Abstract: PROBLEM TO BE SOLVED: To obtain a skin cosmetic capable of exhibiting excellent crease improving effect and good feeling to users by combining a guanidine derivative having a specific structure or its acid addition salt with a synthetic sphingosine. SOLUTION: This skin cosmetic is obtained by combinedly using (A) a guanidine derivative of formula I [A and B are each a 2-8C alkylene; D is a direct bond, CO or a 1-6C alkylene; E is H, an alkyl, an aralkyl or an aryl; (m) is 1-6; (n) is 0-6; R is H, an alkyl, (AO)m -(BO)n -D-E] of formula II [(k) is 1-10; G is H, OH, COOH, sulfonic acid or phoshoric acid] or its acid addition salt and (B) a synthetic sphingosine derivative of formula III (R is a 4-40C hydrocarbon; R to R are each H or a 1-10C hydrocarbon; X and Y are each H or an alkyl). The skin cosmetic is preferably obtained by blending 0.001-50wt.% component A with 0.0001-10wt.% component B. An organic acid or its ester in an amount of 0.001-30wt.% may further be added to the system. The component of formula I is e.g. obtained from a compound of formula IV.
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