公开(公告)号：AU2010327993A1

公开(公告)日：2012-07-12

申请号：AU2010327993

申请日：2010-12-10

Applicant: VERTEX PHARMA

Inventor： SHETH URVI ,  FANNING TEV T D ,  NUMA MEHDI ,  BINCH HAYLEY ,  HURLEY DENNIS JAMES ,  ZHOU JINGLAN ,  HADIDA RUAH SARA S ,  HAZLEWOOD ANNA R ,  SILINA ALINA ,  VAIRAGOUNDAR RAJENDRAN ,  VAN GOOR FREDRICK F ,  GROOTENHUIS PETER DIEDERIK JAN ,  BOTFIELD MARTYN C

IPC: C07D215/56 ,  A61K31/4709 ,  A61P11/00 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/08

Abstract: The present invention relates to 4 -oxo- lH-quinoline- 3 carboxamides as modulators of ATP -Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present Invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：NZ568393A

公开(公告)日：2011-08-26

申请号：NZ56839306

申请日：2006-11-13

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN ,  FANNING LEV T D ,  KRENITSKY PAUL ,  TERMIN ANDREAS ,  JOSHI PRAMOD ,  SHETH URVI

IPC: C07D403/04 ,  A61K31/505 ,  A61P29/00

Abstract: Disclosed are substituted quinazoline compound of formula (IA) or formula (IB), wherein the variables are as defined in the specification, which have the activity as inhibitors of voltage-gate sodium channels, and are suitable for use in the treatment of disease, condition, or disorder that is implicated in the activation or hyperactivity of voltage-gated sodium channels, wherein the disease, condition, or disorder is selected from acute, chronic, neuropathic, or inflammatory pain, arthritis, migraine, cluster headaches, trigeminal neuralgia, herpetic neuralgia, general neuralgias, epilepsy or epilepsy conditions, neurodegenerative disorders, psychiatric disorders such as anxiety and depression, myotonia, arrhythmia, movement disorders, neuroendocrine disorders, ataxia, multiple sclerosis, irritable bowel syndrome, incontinence, visceral pain, osteoarthritis pain, postherpetic neuralgia, diabetic neuropathy, radicular pain, sciatica, back pain, head or neck pain, severe or intractable pain, nociceptive pain, breakthrough pain, postsurgical pain, or cancer pain.

公开(公告)号：NZ569694A

公开(公告)日：2011-06-30

申请号：NZ56969406

申请日：2006-12-21

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN ,  FANNING LEV T D ,  SHETH URVI ,  MARTINBOROUGH ESTHER ,  TERMIN ANDREAS ,  NEUBERT TIMOTHY ,  ZIMMERMANN NICOLE ,  KNOLL TARA ,  WHITNEY TARA ,  KAWATKAR AARTI ,  LEHSTEN DANIELLE ,  STAMOS DEAN ,  ZHOU JINGLAN ,  ARUMUGAM VIJAYALAKSMI ,  GUTIERREZ COREY

IPC: C07D239/42 ,  A61K31/506 ,  A61P25/04 ,  C07D401/12 ,  C07D405/12 ,  C07D417/12 ,  C07D471/10 ,  C07D491/10

Abstract: Disclosed are heterocyclic derivatives represented by general formula (I), or pharmaceutically acceptable salts thereof, wherein x and y are each independently 1 or 2 and x + y is 3, and the substituents are defined within the specification. Also disclosed is the use of the compounds of formula (I) for treating pain.

公开(公告)号：DE602005015231D1

公开(公告)日：2009-08-13

申请号：DE602005015231

申请日：2005-08-31

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN M ,  TERMIN ANDREAS P ,  GONZALEZ JESUS E ,  FANNING LEV T ,  NEUBERT TIMOTHY D ,  KRENITSKY PAUL ,  JOSHI PRAMOD ,  HURLEY DENNIS J ,  SHETH URVI ,  BOGER JOSHUA S

IPC: C07D239/94 ,  A61K31/498 ,  A61P9/06 ,  A61P25/00 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：AT435214T

公开(公告)日：2009-07-15

申请号：AT05807734

申请日：2005-08-31

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN ,  TERMIN ANDREAS ,  GONZALEZ JESUS ,  FANNING LEV ,  NEUBERT TIMOTHY ,  KRENITSKY PAUL ,  JOSHI PRAMOD ,  HURLEY DENNIS ,  SHETH URVI ,  BOGER JOSHUA

IPC: C07D239/94 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：MX2007002582A

公开(公告)日：2008-01-14

申请号：MX2007002582

申请日：2005-08-31

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN M ,  TERMIN ANDREAS P ,  NEUBERT TIMOTHY D ,  GONZALEZ JESUS E III ,  FANNING LEV T D ,  KRENITSKY PAUL ,  JOSHI PRAMOD ,  HURLEY DENNOS J ,  SHETH URVI ,  BOGER JOSHUA S

IPC: A61K31/00 ,  A61P9/06 ,  A61P25/00 ,  C07D239/94 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14

Abstract: La presente invencion se relaciona con compuestos utiles como inhibidores de canales de sodio activados por voltaje. La invencion tambien proporciona las composiciones farmaceuticamente aceptables que comprenden los compuestos de la invencion y los metodos para utilizar las composiciones en el tratamiento de diversos trastornos.

公开(公告)号：MA28909B1

公开(公告)日：2007-10-01

申请号：MA29735

申请日：2007-03-02

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN M ,  TERMIN ANDREAS P ,  GONZALEZ JESUS E III ,  FANNING LEV T D ,  NEUBERT TIMOTHY D ,  KRENITSKY PAUL ,  JOSHI PRAMOD ,  HURLEY DENNIS J ,  SHETH URVI ,  BOGER JOSHUA S

IPC: C07D239/94 ,  A61K31/498 ,  A61P9/06

公开(公告)号：AU2006331608A1

公开(公告)日：2007-07-05

申请号：AU2006331608

申请日：2006-12-21

Applicant: VERTEX PHARMA

Inventor： FANNING LEV T D ,  NEUBERT TIMOTHY ,  ZHOU JINGLAN ,  KAWATKAR AARTI ,  GUTIERREZ COREY ,  SHETH URVI ,  LEHSTEN DANIELLE ,  KNOLL TARA ,  ZIMMERMANN NICOLE ,  WILSON DEAN ,  STAMOS DEAN ,  MARTINBOROUGH ESTHER ,  WHITNEY TARA ,  ARUMUGAM VIJAYALAKSMI ,  TERMIN ANDREAS

IPC: C07D239/42 ,  A61K31/506 ,  A61P25/04 ,  C07D401/12 ,  C07D405/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/10 ,  C07D491/10

Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：CA2628650A1

公开(公告)日：2007-05-24

申请号：CA2628650

申请日：2006-11-13

Applicant: VERTEX PHARMA

Inventor： FANNING LEV T D ,  WILSON DEAN ,  KRENITSKY PAUL ,  JOSHI PRAMOD ,  TERMIN ANDREAS ,  SHETH URVI

IPC: C07D403/04 ,  A61K31/505 ,  A61P29/00

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：AU2006315675A1

公开(公告)日：2007-05-24

申请号：AU2006315675

申请日：2006-11-13

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN ,  JOSHI PRAMOD ,  KRENITSKY PAUL ,  FANNING LEV T D ,  TERMIN ANDREAS ,  SHETH URVI

IPC: C07D403/04 ,  A61K31/505 ,  A61P29/00

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.